2003 Fiscal Year Final Research Report Summary
Role of blood pressure on the progression of human coronary atherosclerosis
| Project/Area Number |
13670739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
YASUNARI Kenichi Osaka City University, Assistant Professor, 大学院・医学研究科, 講師 (90231646)
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| Project Period (FY) |
2001 – 2003
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| Keywords | hypertension / neutrophils / oxidative stress / monocytes / risk factors / coronary artery |
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| Research Abstract |
We have demonstrated that pressure itself increased oxidative stress of human coronary smooth muscle cells (1,3). In experimental animals, we have shown the increased oxidative stress of neutrophils (5). In patients with essential hypertension, we have shown the increased oxidative stress both in neutrophils and monocytes (2) which are modified by antihypertensive drugs such as carvedilolor valsartan (7,8).
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