2002 Fiscal Year Annual Research Report

心不全モデル動物における薬物治療と脂肪酸代謝

Research Project

Project/Area Number	13670750
Research Institution	Niigata university of Pharmacy and Applied Life Sciences
Principal Investigator	渡辺賢一新潟薬科大学, 薬学部・臨床薬理学, 教授 (70175090)
Co-Investigator(Kenkyū-buntansha)	馬梅蕾新潟薬科大学, 薬学部・臨床薬理学, 助手 (20333536)
Keywords	心不全 / アンジオテンシン変換酵素阻害薬 / ベータ遮断薬 / 心臓交感神経機能 / 免疫異常 / アンジオテンシン受容体拮抗薬 / 虚血性心疾患 / 心臓脂肪酸代謝
Research Abstract	ミオシン注射による自己免疫性心筋炎後の拡張型心筋症様モデルラットに、アンジオテンシン受容体拮抗薬やアンジオテンシン変換酵素阻害薬(ACE-I)である、キナプリル及びエナラプリルを投与しその効果を検討した。それらの投薬により心重量と左心室拡張末期圧の低下、さらに線維化の減少が見られた。線維化に関係するTGF-β1とCollagen-IIIのmRNA発現は、心不全群で増加し投薬群で減少した。これらの改善はキナプリル群で著明であった。同じACE-Iでも作用の違いに注目すべきであることが明らかとなった[J Cardiovascul Pharmacol. 2003;41(Sup-1):S93-S97. J Cardiovascul Pharmacol. 2003;41(Sup-1):S105-S110. Mol Cell Biochem. 2003(in press).]。一方、ベータ遮断薬のカルベジロールの投与では、心臓交感神経機能の改善がみられた(J Nucl Med. 2002;43(4):531-535.)。ヒト虚血性心疾患患者では脂肪酸代謝と交感神経機能が傷害され、薬物治療により改善する群は予後良好であった(J Nucl Med. 2002;43(11):1476-1481.)。

Research Products
(9 results)

All Other

All Publications (9 results)

[Publications] Watanabe K et al.: "Myocardial Sympathetic Denervation, Fatty Acid Metabolism and Left Ventricular Wall Motion in Vasospastic Angina"J Nucl Med. 43・11. 1476-1481 (2002)
[Publications] Ma M, Watanabe K et al.: "Different gene expression of potassium channels by thyroid hormone and an antithyroid drug between the atrium and ventricle of rats"Jpn Heart J. 44. 101-110 (2003)
[Publications] Watanabe K et al.: "Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy"J Nucl Med. 43(4). 531-535 (2002)
[Publications] Wen Juan, Watanabe K et al.: "Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis"Mol Cell Biochem. (in press). (2003)
[Publications] Mayuyama S, Watanabe K et al.: "Fenofibrate, a peroxisome proliferator-activated receptor α activator, suppresses experimental autoimmune myocarditis by stimulating the interleulkin-10 pathway in rats"J Atheroscler Thromb. 9. 87-92 (2002)
[Publications] Watanabe K et al.: "Betaxolol Improves Survival and Changes Natriuretic Peptide Expression in Rats with Heart Failure"J Cardiovascul Pharmacol. 41. S99-103 (2003)
[Publications] Watanabe K et al.: "Comparative Effects of Angiotensin II Receptor Blockade(Candesartan)with ACE Inhibitor(Quinapril) in Rats with Dilated Cardiomyopathy J Cardiovascul Pharmacol. 2003 ; 41(Sup-1) : S93-S97"J Cardiovascul Pharmacol. 41. S93-97 (2003)
[Publications] Takahashi T, Watanabe K et al.: "Improved synthesis of pure[18F]fluoro-compounds for PET studies from bromo-compounds"Appl. Radiat. Isot. (in press). (2003)
[Publications] Tachikawa H, Watanabe K et al.: "Angiotensin II type 1 receptor blocker, valsartan, prevented cardiac fibrosis in rat cardiomyopathy after autoimmune myocarditis"J Cardiovascul Pharmacol. 41. S105-110 (2003)

2002 Fiscal Year Annual Research Report

心不全モデル動物における薬物治療と脂肪酸代謝

Principal Investigator

渡辺 賢一 新潟薬科大学, 薬学部・臨床薬理学, 教授 (70175090)

Research Products

[Publications] Watanabe K et al.: "Myocardial Sympathetic Denervation, Fatty Acid Metabolism and Left Ventricular Wall Motion in Vasospastic Angina"J Nucl Med. 43・11. 1476-1481 (2002)

[Publications] Ma M, Watanabe K et al.: "Different gene expression of potassium channels by thyroid hormone and an antithyroid drug between the atrium and ventricle of rats"Jpn Heart J. 44. 101-110 (2003)

[Publications] Watanabe K et al.: "Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy"J Nucl Med. 43(4). 531-535 (2002)

[Publications] Wen Juan, Watanabe K et al.: "Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis"Mol Cell Biochem. (in press). (2003)

[Publications] Mayuyama S, Watanabe K et al.: "Fenofibrate, a peroxisome proliferator-activated receptor α activator, suppresses experimental autoimmune myocarditis by stimulating the interleulkin-10 pathway in rats"J Atheroscler Thromb. 9. 87-92 (2002)

[Publications] Watanabe K et al.: "Betaxolol Improves Survival and Changes Natriuretic Peptide Expression in Rats with Heart Failure"J Cardiovascul Pharmacol. 41. S99-103 (2003)

[Publications] Watanabe K et al.: "Comparative Effects of Angiotensin II Receptor Blockade(Candesartan)with ACE Inhibitor(Quinapril) in Rats with Dilated Cardiomyopathy J Cardiovascul Pharmacol. 2003 ; 41(Sup-1) : S93-S97"J Cardiovascul Pharmacol. 41. S93-97 (2003)

[Publications] Takahashi T, Watanabe K et al.: "Improved synthesis of pure[18F]fluoro-compounds for PET studies from bromo-compounds"Appl. Radiat. Isot. (in press). (2003)

[Publications] Tachikawa H, Watanabe K et al.: "Angiotensin II type 1 receptor blocker, valsartan, prevented cardiac fibrosis in rat cardiomyopathy after autoimmune myocarditis"J Cardiovascul Pharmacol. 41. S105-110 (2003)

渡辺賢一新潟薬科大学, 薬学部・臨床薬理学, 教授 (70175090)