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2003 Fiscal Year Final Research Report Summary

Molecular mechanism of spontaneous remission from renal injury

Research Project

Project/Area Number 13671118
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionNagasaki University

Principal Investigator

MIYAZAKI Masanobu  Nagasaki University, Hospital Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (10246100)

Co-Investigator(Kenkyū-buntansha) KONHO Shigeru  Nagasaki University, Postgraduate School of Medicine, Professor, 大学院・医歯薬学総合研究科, 教授 (80136647)
Project Period (FY) 2001 – 2003
Keywordsangiotensin II / aldosterone / angiogenesis / glomerulonephritis / VEGF / CYP11B2
Research Abstract

In the present study, we examined the role of angiotensin II in the process of spontaneous remission of glomerular injury in experimental mesangial proliferative glomerulonephritis and tested the expression of mRNA for CYP11B, the key enzyme of aldosterone synthesis in human renal biopsy specimens using in situ hybridization. We induced reversal mesangial proliferative glomerulonephritis by Habu-snake venom injection. Compared with wild type mice, the delay of remission from glomerular injury, including expansion of mesangial area and reduced number of glomerular capillary wall, was observed in mice without angiotensin II receptor type 1. Treatment of VEGF (vascular endothelial cell growth factor) promoted restoration of glomerularr injury in the model. In the second study, CYP11B2 mRNA was expressed in glomerular cells, such as mesangial cells, glomerular epithelial and endothelial cells, and infiltrating cells and atrophic tubular cells in the interstitium. Moreover, these expressions of CYP 11 B2 mRNA were significantly correlated with the degree of their tissue injury. Our results suggested that angiotensin II is important in the reconstitution of glomerular capillary and that aldosterone produced in human renal tissue was involved in renal tissue damage.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Miyazaki M, Nishio T, Abe K, Furusu A, Koji T, Kohno S: "Regulation of renal extracellular matrix metabolism"Contrib Nephrol. 139. 141-155 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ashizawa M.Miyazaki M, Abe K, et al.: "Detection of nuclear factor-kB in IgA nephropathy using Southwestern histocheroistry."Am J Kid Dis. 42(1). 76-86 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishino T, Miyazkai M, Abe K, et al.: "Antisense oligonucleotides against collagen-binding stress protein HSP 47 suppress peritoneal fibrosis in rats"Kidney Int. 64(3). 887-896 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mishima Y, Miyazkai M, Abe K, et al.: "Enhanced expression of heat shock protein 47 in rat model of peritoneal fibrosis."Perit Dial Int. 23(1). 14-22 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Horita Y.Hayashida K, Fukuchi, K, et al.: "Acetazolaraide assisted Tc-99m MAG3 renography to assess renal blood flow reserve."Ann Nucl Med. 17(2). 139-144 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyazaki M, Nishio T, Abe K, Furusu A, Koji T, Kohno. S: "Regulation of renal extracellular matrix metabolism"Contrib Nephrol. 139. 141-155 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ashizawa M, Miyazaki M, Abe K, et al.: "Detection of nuclear factor-kB in IgA nephropathy using Southwestern histochemistry."Am J Kid Dis. 42(1). 76-86 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishino T, Miyazkai M, Abe K, et al.: "Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats"Kidney Int. 64(3). 887-896 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mishima Y, Miyazkai M, Abe K, et al.: "Enhanced expression of heat shock protein 47 in rat model of peritoneal fibrosis."Pent Dial Int. 23(1). 14-22 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Horita Y, Hayashida K, Fukuchi, K, et al.: "Acetazolamide assisted Tc-99m MAG3 renography to assess renal blood flow reserve."Ann Nucl Med. 17(2). 139-144 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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