2003 Fiscal Year Final Research Report Summary
Invesigation on signal transduction of erythropoietin in vascular smooth muscle cells
| Project/Area Number |
13671125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jichi Medical School |
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Principal Investigator |
KUSANO Eiji Jichi Medical School, Div Nephrol, Professor, 医学部, 教授 (50102249)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Yasuhiro Jichi Medical School, Div Nephrol, Associate professor, 医学部, 助教授 (50212676)
KOMATSU Norio Jichi Medical School, Div Hematol, Associate professor, 医学部, 助教授 (50186798)
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| Project Period (FY) |
2001 – 2003
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| Keywords | signal transuduction / erythropoietin / hypertension / vasular smooth muscle cell / MAPK system / cAMP / endothelial progenitor cells |
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| Research Abstract |
We have examined mechanism of pathogenesis of the eythropoietin (EPO)-induced hypertension until now in cultured vascular smooth muscle cell and by dialysis patients. Since antiplatelet drug & induces inducible nitric oxide synthase (iNOS). this drug brings about direct decrease of blood pressure with the stimulation of the NO production, and the possibility of inducing decrease of blood pressure by the induction of the apoptosis of vasucular smooth muscle through the remodeling of blood vessel has been reported. In the present study, we would like to clarify the mechanism of pathogenesis of the EPO-induced hypertension by investigating the signal transduction system in vascular smooth muscle cell.
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[Publications] Inoue M, Kusano E, Ito C, Akimoro T, Iimura O, Nemoto J, Amemiya M, Muto S, Asano Y.: "The anti-platelet agent, ticlopidine, upregulates interleukin-1-Beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells."Exp Nephrol. 10(4). 267-274 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Ito, C., Kusano, E., Akimoto, T., Takeda, S., limura, O., Ando, Y., Asano, Y.: "Cyclic AMP inhibits erythropoietin-induced activation of MAPK cascades in rat vascular smooth muscle cells."34th Annual Meeting of Am.Soc.Nephrol., San Francisco, Oct.10-17, 2001(Abs.J.Am.Soc.Nephrol.12(9) : 613A, 2001). (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Ito, C., Yamamoto, H., Furukawa, Y., Takeda, S., Watanabe, Y., Akimoto, T., Iimura, O., Ando, Y., Kusano, E., Asano, Y.: "Cyclic AMP inhibits PDGF-induced mesangium cell proliferation through negative expression of cyclin D1 and Cdk2."35th Annual Meeting of Am.Soc.Nephrol., Philadelphia, Oct.30-Nov.4, 2002 (Abs.J.Am.Soc.Nephrol.13 : 92A, 2002). (2002)
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「研究成果報告書概要(欧文)」より
