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2002 Fiscal Year Final Research Report Summary

Developmental changes in cerebral optical parameters in neonates using near-infrared time-resolved spectroscopy

Research Project

Project/Area Number 13671140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKanagawa University (Faculty of Medicine)

Principal Investigator

ISOBE Kenichi  Kagawa University, Pediatrics, Associate Professor, 医学部, 助教授 (00159815)

Co-Investigator(Kenkyū-buntansha) NAMBA Masanori  Kagawa University, Pediatrics, Associate Assistant, 医学部, 助手 (90237636)
KUSAKA Takashi  Kagawa University, Pediatrics, Assistant Professor, 医学部付属病院, 講師 (50274288)
IMAI Tadashi  Kagawa University, Pediatrics, Assistant Professor, 医学部付属病院, 講師 (60176477)
KAWADA Kou  Kagawa University, Pediatrics, Associate Assistant, 医学部付属病院, 助手 (40284369)
Project Period (FY) 2001 – 2002
Keywordsnear-infrared spectroscopy / time-resolved spectroscopy / piglet / new born infant / differential pathlength factor / light reduced scattering coefficient / cerebral hemoglobin oxygen saturation / cerebral blood volume
Research Abstract

We used a portable three-wavelength near-infrared time-resolved spectroscopy (TRS) system to measure the light absorption coefficient (μa), light reduced scattering coefficient (μ's), hemoglobin (Hb) concentration and Hb oxygen saturation (SO2) in the brain. In a basic study using a piglet hypoxic model, the relationship between differential pathlength factor (DPF) and hemoglobin oxygenation state in the brain was investigated. In a clinical study using neonates, the developmental changes in those parameters were investigated.
(1)Measurement of cerebral light pathlength by TRS in a piglet model of hypoxia
We investigated the relationships of mean light pathlength with arterial (SaO2) and sagittal sinus venous Hb oxygen saturation (SvO2) in the brain under the condition of stepwise hypoxia loading. The ratio of mean light pathlength to interoptode distance is defined as the DPF. At FiO2 of 0.21, the DPF values at 761,795 and 835 nm were estimated to be 5.02±0.36, (mean±SD), 5.31±0.32 and 4.92±0.34,respectively. There was a significant positive linear correlation between DPF at 761 and 795 nm and SaO2. The DPF and SvO2 also showed a significant positive linear correlation at 761 and 795 nm. The factors influencing the DPF were increase in deoxyHb and decrease in oxyHb during hypoxia.
(2)Measurement of cerebral optical parameter,802 and cerebral blood volume by TRS in the developing brain
The subjects were 19 neonates whose gestational age was 25 to 41 weeks. The DPF values at 761,795 and 835 nm were estimated to be 4.9±0.52,5.02±0.53 and 4.64±0.46,respectively. The values of μ's at each wavelength were 6.30±1.30,6.04±1.11 and 6.37±1.45/cm respectively. The CBV was 2.2±0.6 ml/100g, which is similar to the value previously reported. The SO2 was 73±4.0% under 95-100% of SpO2. The SO2 and postconceptual weeks showed a significant negative linear relationship. The reason for this is the increase in cerebral oxygen consumption with development of the brain.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Kusaka T, Hisamatsu Y, Kawada K, Okubo K, Okada H, Namba M, Imai T, Isobe K, Itoh S: "Measurement of Cerebral Optical Pathlength as a Function of Oxygenation Using Near-infrared Time-resolved Spectroscopy in a Piglet Model of Hypoxia"Opt Rev. 10. 466-469 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Isobe K, Kusaka T, Fujikawa Y, Okubo K, Nagano K, Yasuda S, Kondo M, Itoh S, Hirao K, Onishi S: "Measurement of cerebral oxygenation in neonates after vaginal delivery and cesarean section using full-spectrum near infrared spectroscopy"Comp Biochem Phys A. 132. 133-138 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kusaka T, Okubo K, Nagano K, Yasuda S, Kawada K, Imai T, Isobe K, Itoh S: "Activation of the visual cortex in newborn infants under natural sleep using multichannel near-infrared spectroscopy"Adv Exp Med Biol. 510. 255-259 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kusaka T, Mastuura S, Fujikawa Y, Okubo K, Kawada K, Namba M, Okada H, Imai T, Isobe K, Itoh S: "Relationship between cerebral interstitial levels of amino acids and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets"Pediatr Res. 55. 273-279 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kusaka T, Kawada K, Okubo K, Nagano K, Namba M, Okada H, Imai T, Isobe K, Itoh S: "Noninvasive optical imaging in the visual cortex in young infants"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kusaka T, Hisamatsu Y, Kawada K, Okubo K, Okada H, Namba M, Imai T, Isobe K, Itoh S: "Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia"Opt Rev. 10. 466-469 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Isobe K, Kusaka T, Fujikawa Y, Okubo K, Nagano K, Yasuda S, Kondo M, Itoh S, Hirao K, Onishi S: "Measurement of cerebral oxygenation in neonates after vaginal delivery and cesarean section using full-spectrum infrared spectroscopy"Comp Biochem Phys. A132. 133-138 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kusaka T, Okubo K, Nagano K, Yasuda S, Kawada K, Imai T, Isobe K, Itoh S: "Activation of the visual cortex in newborn infants under natural sleep using multichannel near-infrared spectroscopy"Adv Exp Med Biol. 510. 255-259 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kusaka T, Mastuura S, Fujikawa Y, Okubo K, Kawada K, Namba M, Okada H, Imai T, Isobe K, Itoh S: "Relationship between cerebral interstitial levels of amino acids and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets"Pediatr Res. 55. 273-279 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kusaka T, Kawada K, Okubo K, Nagano K, Namba M, Okada H, Imai T, Isobe K, Itoh S: "Noninvasive optical imaging in the visual cortex in young infants"Hum Brain Mapp. 22. 122-32 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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