2002 Fiscal Year Final Research Report Summary
DNA analysis of single fetal nucleated erythrocytes (NRBCs) from maternal blood
| Project/Area Number |
13671146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | KANAZAWA MEDICAL UNIVERSITY |
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Principal Investigator |
TAKABAYASHI Haruo Kanazawa Medical University, Medical Research Institute, Associate Professor, 総合医学研究所, 助教授 (60171542)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Mamoru Kanazawa Medical University, Medical Research Institute, Lecturer, 総合医学研究所, 助手 (50319068)
ICHIKAWA idetaka Kanazawa Medical University, Department of Medical Zoology, Lecturer, 医学部, 助手 (40151469)
TANINO Mikio Kanazawa Medical University, Department of Pathology, Associate Professor, 医学部, 助教授 (60135051)
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| Project Period (FY) |
2001 – 2002
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| Keywords | maternal blood / nucleated erythrocyte / fetal diagnosis / DNA diagnosis / micromanipulation / PEP / PCR / FISH |
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| Research Abstract |
Micromanipulation of fetal cells, in combination with FISH technology, even if present some limitations, especially high cost and intensive labor, gives the great advance to allow one to retrieve exclusively cells that are fetal in origin, avoiding or minimizing maternal cells contamination ; in addition, FISH technology beside its limits, permits to analyze multiple chromosomes at the single time for non invasive prenatal diagnosis of the most common aneuploidies.
However, what we believe most important is to bring additional information and further confirmation that Fetal Cells Analysis in Maternal Blood, using different enrichment procedures in combination to sensitive analysis techniques, may applied within the near future to prenatal non invasive diagnosis of genetic diseases.
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Research Products
(14 results)
