| Project/Area Number |
13671159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
TAKASU Nobuyuki University of the Ryukyus, Department of Medicine, Professor, 医学部, 教授 (20020927)
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| Co-Investigator(Kenkyū-buntansha) |
KOUKI Tuyoshi University of the Ryukyus, Department of Medicine, Instructor, 医学部附属病院, 助手 (80273415)
SHIMABUKURO Michio University of the Ryukyus, Department of Medicine, Assistant Professor, 医学部附属病院, 講師 (60271144)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Graves' disease / Hyperthyroidism / Remission / CTLA-4 / TSAb (thyroid stimulating Ab) / TRAb (TSH receptor Ab) / CTLA-4遺伝子多型 / 放射線療法 |
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| Research Abstract |
We studied whether a patient with Graves' disease will go into remission during antithyroid drug (ATD) treatment. Remission of Graves' hyperthyroidism is predicted by a smooth decrease in TSH receptor antibody (TRAb) during ATD treatment. Cytotoxic T cell lymphocyte-associated molecule-4 (CTLA-4) may play an important role in the development of Graves' hyperthyroidism and in its remission. We studied A/G polymorphism at position 49 in exon 1 of the CTLA-gene in Japanese Graves' patients. We revealed the association of CTLA-4 polymorphism with remission of Graves' hyperthyroidism.
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