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2002 Fiscal Year Final Research Report Summary

INDICATION OF BREAST CONSERVATIVE SURGERY FOR PRIMARY BREAST CANCER USING COMPUTER GRAPHIC THREE-DIMENSIONAL RECONSTRUCTION OF THE MAMMARY DUCT-LOBULAR SYSTEMS

Research Project

Project/Area Number 13671246
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionFUKUSHIMA MEDICAL UNIVERSITY

Principal Investigator

TAKENOSHITA Seiichi  FUKUSHIMA MEDICAL UNIVERSITY, THE SECOND DEPARTMENT OF SURGERY, PROFESSOR, 医学部, 教授 (10167489)

Project Period (FY) 2001 – 2002
KeywordsBreast cancer / Intraductal spread / Computer graphics / Three-dimensional reconstruction / Brest-conserving surgery / Mammary ductal / lobular system / 乳管腺葉系
Research Abstract

Intraductal spread of breast cancer can occur along the mammary duct/lobular systems (MDLS) with no invasion of tissues. As ductal anastomoses in the MDLS are considered a possible risk factor for extensive intraductal spread of breast cancer, the architecture of MDLS has important therapeutic implications for patients treated by breast-conserving surgery. An entire breast resected by subcutaneous mastectomy from a 69-year-old woman with ductal carcinoma in situ (DCIS) was examined in subgross sections by stereomicroscopic and histologic techniques. Serial 2-mm sections were subjected to computer-assisted complete three-dimensional reconstruction of all MDLS. The entire breast used contained 16 MDLS, radially arranged with the nipple at the center. Of 16 MDLS, 4 (25.0%) had ductal anastomoses while the remaining 12 MDLS had no ductal anastomoses and completely independent regional anatomy. Ductal anastomoses were observed at 11 sites in the 4 MDLS. The 2 (18.2%) of 11 ductal anastomoses that connected different MDLS were situated more than 4 cm from the nipple. The remaining 9 connected ducts within the same MDLS ; their location varied from near the nipple to the peripheral region. In the case examined, DCIS extended only within a single MDLS, and did not spread between different MDLS via ductal anastomoses. The complete architecture of all MDLS in an entire breast was studied three-dimensionally for the first time to the authors' knowledge. The risk of extending intraductal spread during surgery may be greater where intraductal lesions extend more peripherally than centrally. Individualizing the extent of surgical resection based on the anatomy of MDLS should help to minimize the risk of leaving residual carcinoma at surgical margins.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 大竹 徹他: "コンピューター支援下3次元再構築による乳房内全乳管腺葉系の解剖学的検討"乳癌の臨床. 15(5). 610-611 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohtake T, et al.: "Three-dimensional reconstruction of the whole breast duct/lobular units"Breast Cancer Research and Treatment. 64(1). 104-104 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohtake T, et al.: "Giant mammary hamartoma diagnosed by stereomicroscopic analysis of the mammary glandular tree in an adolescent girl"Surgery Today. 31. 433-437 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohtake T, et al.: "Computer-assisted complete three-dimensional reconstruction of the mammary ductal/lobular systems. Implications of ductal anastomoses for breast-conserving surgery"Cancer. 91. 2263-2272 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe T, et al.: "Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer"Br J Surg. 88. 704-707 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohtake T, et al.: "Computer Assisted Complete Three-dimensional Reconstruction of Multiple Breast Carcinomas. Pathological Analysis on Discrimination between Multicentric and Multifocal Tumors"Breast Cancer Research and Treatment. (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OHTAKE T, et al.: "INTRADUCTAL EXTENSION OF PRIMARY INVASIVE BREAST CARCINOMA TREATED BY BREAST-CONSERVATIVE SURGERY"CANCER. 76(1). 32-45 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] RIKIYA A, et al.: "GROWTH OF BREAST CANCER AND LIMITED SURGERY"BREAST CANCER. 3. 1-7 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] TSUCHIYA A, et al.: "PROGNOSTIC RELEVANCE OF TN EXPRESSION IN BREAST CANCER"BREAST CANCER. 6. 175-180 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KIMIJIMA I, et al.: "SCATTERED FAT INVASION : AN INDICATION FOR POOR PROGNOSIS IN PREMENOPAUSAL AND FOR POSITIVE ESTROGEN RECEPTOR IN POSTMENOPAUSAL BREAST CANCER PATIENTS"ONCOLOGY. 59. 25-30 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OHTAKE T, et al.: "THREE-DIMENSIONAL RECONSTRUCTION OF THE WHOLE BREAST DUCT/LOBULAR UNITS"BREAST CANCER RESEARCH AND TREATMENT. 64(1). 104 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OHTAKE T, et al.: "GIANT MAMMARY HAMARTOMA DIAGNOSED BY STEREOMICROSCOPIC ANALYSIS OF THE MAMMARY GLANDULAR TREE IN AN ADOLESCENT GIRL"SURGERY TODAY. 31. 433-437 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OHTAKE T, et al.: "COMPUTER-ASSISTED COMPLETE THREE-DIMENSIONAL RECONSTRUCTION OF THE MAMMARY DUCTAL/LOBULAR SYSTEMS"CANCER. 91. 2263-2272 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] WATANABE T, et al.: "SENTINELNODE BIOPSY WITH TECHNETIUM-99M COLLOIDAL RHENIUM SULPHIDE IN PATIENTS WITH BREAST CANCER"BRITISH JOURNAL OF SURGERY. 88. 704-707 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OHTAKE T, et al.: "COMPUTER-ASSISTED COMPLETE THREE-DIMENSIONAL RECONSTRUCTION OF MULTIPLE BREAST CARCINOMAS"BREAST CANCER RESEARCH AND TREATMENT. 64(1). 104 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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