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2003 Fiscal Year Final Research Report Summary

Mucin glycoproteins in human gallbladder carcinoma and their biological effects on tumor invasion and metastasis capability.

Research Project

Project/Area Number 13671279
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

TODOROKI Takeshi  University of Tsukuba, Institute of Clinical Medicine, Associate Professor, 臨床医学系, 助教授 (70114105)

Co-Investigator(Kenkyū-buntansha) SHODA Junichi  University of Tsukuba, Institute of Clinical Medicine, Assistant Professor, 臨床医学系, 講師 (90241827)
IRIMURA Tatsuro  University of Tokyo, Faculty of Pharmaceutical Science, Professor, 大学院・薬学系研究科, 教授 (80092146)
Project Period (FY) 2001 – 2003
Keywordsgallbladder carcinoma / animal model / mucin glycoprotein / oncogene / signal transduction / gallbladder carcinogenesis / 転移・浸潤 / 腫瘍生物学
Research Abstract

The overall prognosis of gallbladder carcinoma is poor because of a high percentage of advanced cases at the time of operation and thereby a lower curability. pT2 carcinoma is limited in the gallbladder wall, and therefore a high curability as well as a better prognosis can be expected. However, the prognosis has not been necessarily good since distant recurrences are found in some cases of pT2 carcinomas. Alterations in glycosilation of mucins, such as an alteration in the site of O-glycosylation of mucin core proteins or an enhanced sialylation of carbohydrate structures, are known in the process of malignant transformation.
Sialylated MUC1 recognized by a mAb MY.1E12 (Jpn J Cancer Res 1996;87:488-496) has been used as a marker for invasive adenocarcinomas. In pT2 gallbladder carcinoma, the high level expression of stromal localization of sialylated MY.1E12-reactive-MUC1 at the invading sites correlates with the aggressiveness of the disease, such as the tendency to form distant metastasis.
Thus, alterations in carbohydrate chains of carcinoma-producing mucin glycoproteins potentiate the capability of tumor invasion and/or metastasis.

  • Research Products

    (8 results)

All 2003 2002 2001

All Journal Article (8 results)

  • [Journal Article] Patterns and predictors of failure after curative resections2003

    • Author(s)
      Todoroki T et al.
    • Journal Title

      Annals of Surgical Oncology 10

      Pages: 1176-1183

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Patterns and predictions of failure after curative resections.2003

    • Author(s)
      Todoroki T et al.
    • Journal Title

      Annals of Surgical Oncology 10

      Pages: 1176-1183

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of cyclooxygenase-2 in the subserosal layer2002

    • Author(s)
      Kawamoto T et al.
    • Journal Title

      International Journal of Cancer 98

      Pages: 427-434

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of cyclooxygenase-2 in carcinoma of the2002

    • Author(s)
      Asano T et al.
    • Journal Title

      Clinical Cancer Research 8

      Pages: 1157-1167

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of cyclooxygenase-2 in the subserosal layer.2002

    • Author(s)
      Kawamoto T et al.
    • Journal Title

      International Journal of Cancer 98

      Pages: 427-434

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of cyclooxygenase-2 in carcinoma of the Clinical2002

    • Author(s)
      Asano T et al.
    • Journal Title

      Cancer Research 8

      Pages: 1157-1167

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of MUC1 mucins in the subserosal layer2001

    • Author(s)
      Kawamoto T et al.
    • Journal Title

      Clinical Cancer Research 7

      Pages: 1333-1342

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of MUC1 mucins in the subserosal layer.2001

    • Author(s)
      Kawamoto T et al.
    • Journal Title

      Clinical Cancer Research 7

      Pages: 1333-1342

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2006-07-11  

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