2002 Fiscal Year Final Research Report Summary

Basic research for the establishment of anti-angiogenic therapy by antibody to VEGF

Research Project

Project/Area Number	13671288
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Kanazawa University
Principal Investigator	TAKAHASHI Yutaka Cancer Research Institute, Kanazawa University Associate Professor, がん研究所, 助教授 (10179541)
Project Period (FY)	2001 – 2002
Keywords	Angiogenesis / VEGF / Liver metastasis
Research Abstract	I examined the effect of antibody to VEGF on two cell lines, KKLS and KM12sm : I have previously reported that VEGF upregulated in the orthotopic implantation of KKLS, and bFGF did in that of KM12sm. Antibody to VEGF inhibited the liver metastasis of KKLS, while did not that of KM12sm. Moreover, mRNA of other angiogenic factors such as bFGF did not upregulate in KKLS after therapy of antibody to VEGF therapy. From these results, it is suggested that antibody to VEGF should be given to the tumor whose VEGF upregulated and we can give it for a long time.

(4 results)