2003 Fiscal Year Final Research Report Summary
Molecular targetting therapy based on regulation of HER2 protein in advanced gastro-intestinal cancers
| Project/Area Number |
13671313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | 大分医科大学 |
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Principal Investigator |
INOMATA Masafumi Oita University, Faculty of Medicine, Surgery I, Assistant Professor, 医学部, 講師 (60315330)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Kazuhiro Beppu Medical Center, Surgery, Director, 外科, 医長 (70325710)
SHIRAISHI Norio Oita University, Faculty of Medicine, Surgery I, Associate Professor, 医学部, 助教授 (20271132)
ADACHI Yosuke Gihu University, Faculty of Medicine, Surgery I, Professor, 医学部, 教授 (90221043)
ISHIKAWA Koichi Oita University, Faculty of Medicine, Surgery I, Assistant Professor, 医学部, 助手 (30363550)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Gastric Cancer / Peritoneal Dissemination / Molecular Targetting Therapy / HER2 / Murine Metastatic Model |
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| Research Abstract |
In this study, we have clarified the possibility of clinical application of a biotherapy based on regulation of HER2 protein in patients with gastro-intestinal cancer.
(A)Retrospective clinico-pathological study :
Overexpression of HER2 protein was associated with histologic type and liver metastasis, and was a prognostic factor in patients with Well-differentiated gastric cancer.
(B)In vitro study :
Cell growth of gastric cancer cell line, NCI-N87, expressing HER2 protein, was supressed by anti-HER2 antibody.
(C)In vivo study :
Tumor growth of NCI-N87 in subcutaneous inplantation was supressed by anti-HER2 antibody. These results suggested that A new therapy using a monoclonal antibody against HER2 protein was a potential candidate for a strategy of recurrence of well-differentiated gastric cancer, and its application could be decided by examining the status of HER2 expression of resected primary tumor.
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