2003 Fiscal Year Final Research Report Summary
Assessment of the intestinal permeability and gastrointestinal toxicity by anticancer drugs
| Project/Area Number |
13671365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
INUTSUKA Sadaaki Fukuoka Dental College, Surgery, Lecturer, 歯学部, 講師 (40258596)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Masayuki Fukuoka Dental College, Surgery, Lecturer, 歯学部, 講師 (40330972)
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| Project Period (FY) |
2001 – 2003
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| Keywords | S-1 / Intestinal permeability / Chemotherapy / Oxonic acid / mannitol負荷試験 |
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| Research Abstract |
Although intestinal permeability is known to increase in conditions of stress (such as septic shock, and ischemia-reperfusion), the mechanism of gut barrier dysfunction during chemotherapy remains to be elucidated. We designed an experiment to assess the extent of damage or an increase in permeability of intestinal mucosa of rat after administration of anti cancer drugs.
Experiment 1 : The rats were given the anticancer drug after gastrectomy, and their intestinal permeability were estimated by an injection of FITC-dextran. A linear regression analysis revealed a positive significant correlation between FITC-dextran levels and plasma nitric oxide levels. When the anticancer drug was administrated, the mucosal atrophy and decreased expression of CD44 were revealed.
Experiment 2 : Rats were given S-1, new anticancer drug, which consists of tegafur, CDHP, and oxonic acid. The rats' intestinal permeability was determined by lactulose / mannitol test. The gastrointestinal toxicity resulting from administration of tegafur is accompanied by an impaired gut barrier function measurable as an increase in intestinal permeability to lactulose / mannnitol.
Experiment 3 : The serum SOD levels in rats were increased after administration of anticancer drugs. The serum SOD levels of patients who were suffering from gastric, colorectal or breast cancer were measured during chemotherapy. There correlation between prognosis of patients and increase of SOD levels were increase after chemotherapy.
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