2003 Fiscal Year Final Research Report Summary
A new turn of cell cycle which were seen from over expression of cyclin family -checkpoint control and cancer-
| Project/Area Number |
13671366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
HONDA Masayuki Fukuoka Dental College, Surgery, Lecturer, 歯学部, 講師 (40330972)
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| Co-Investigator(Kenkyū-buntansha) |
INUTSUKA Sadaaki Fukuoka Dental College, Surgery, Lecturer, 歯学部, 講師 (40258596)
NOZOE Tadahiro Fukuoka Dental College, Surgery, Lecturer (90325457)
KORENSGA Daisuke Fukuoka Dental College, Surgery, Professor (90170414)
YASUDA Mitsuhiro Fukuoka Dental College, Surgery, Assistant (90269043)
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| Project Period (FY) |
2001 – 2003
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| Keywords | cyclinA / cyclinB1 / Ki-67 / PCNA / p53 / esophagial cancer / gastric cancer / colorectal cancer |
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| Research Abstract |
PURPOSE : This study was done to determine if overexpression of cyclinA, cyclinB1, Ki-67, PCNA and p53 with digestive organ cancer. METHODS : The expressions of Cyclins were immunohistologically determined with digestive organ cancer. The data were compared with findings obtained by p21 or Ki-67 immunohistological stainings. RESULTS : (1)Infiltration of lymphocytes with germinal center cell was observed beneath 17(68%) out of superficial SCCs with cyclinA expression and 15(75.5%) out of 20 superficial SCCs without cyclinA expression. Although 16(94.1%) out of 17 superficial SCCs with cyclinA expression were associated with cyclinA expression in germinal center cells in infiltrated lymphoid follicles beneath the tumors, only 2(13.3%) out of 15 superficial SCCs without cyclinA expression coexisted with cyclinA expression inlymphoid follicles beneath the tumors (p<0.0001). (2)CyclinB1 was expressed in 62 (57%) patients with colorectal cancer and in 32 (53%) of those with gastric cancer. I
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n cases with colorectal cancer, the incidence of Dukes B tumors in the cyclinB1 positive cases was significantly higher than that in the cyclinB1 negative cases (p<0.05). The incidence of lymph node metastasis in the cyclinB1 positive cases was significantly lower than that in cyclinB1 negative cases (p<0.05). Similar tendency was observed with regard to lymphatic permeation and venous invasion (p<0.05). There were no correlations of cyclinB1 negative tumors with higher proliferative activities determined by Ki-67, PCNA and p53 analyses. CONCLUSIONS : (1)CyclinA expression in the germinal center cells of the lymphoid follicles beneath the superficial SCCs of the esophagus might be an immunological signal toward the proliferation and progression of the tumors. (2)These findings suggested that the cyclinB1 negative tumors might have a higher tendency for tumor invasion and metastasizing to lymph node, and the potential role of cyclinB1 overexpression on the metastatic formation was indicated. Less
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