2002 Fiscal Year Final Research Report Summary
Molecular biological study on pathogenesis of thymic epithelial tumors by microarray method
| Project/Area Number |
13671384
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OKUMURA Meinoshin Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40252647)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHTA Mitsunori Osaka University, School of Medicine, Assistant Professor, 医学系研究科, 助手 (30203805)
MINAMI Masato Osaka University, School of Medicine, Assistant Professor, 医学系研究科, 助手 (10240847)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | Thymoma / WHO histological classification / DNA chip |
|---|
| Research Abstract |
WHO histological classification of thymic epithelial tumors has been shown to reflect their biological behavior. This study was designed to determine whether WHO histological classification reflects difference of expression of the specific genes
RNAs were obtained from the primary culture of thymomas, and were subjected to the microarray study. RNAs derived from type AB tumor and type B2 tumor were compared. Assay was done twice in 2 independent sets of tumors
There were 333 genes whose expression was more than two times in type B2 tumor than in type AB tumor,,and 395 genes whose expression was more than 2 times in type AB tumor than in type B2 tumor, reproducibly
|
-
-
-
-
[Publications] Okumura M, Miyoshi S, Fujii Y, Takeuchi Y, Shiono H, Inoue M, Fukuhara K, Kadota Y, Tateyama H, Eimoto T, Matsuda H.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms A study of 146 consecutive tumors"The American J.Surgical Pathology. 25(1). 103-110 (2001)
Description
「研究成果報告書概要(欧文)」より
-
-
