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2002 Fiscal Year Final Research Report Summary

Clinical Study for chronic compressive disorders of the spinal cord-Elucidation of the pathogenesis and Selection of the therapy-

Research Project

Project/Area Number 13671419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionAKITA UNIVERSITY

Principal Investigator

ITOH Yasunobu  Akita Univ. Sch. of Med., Associate Professor, 医学部, 助教授 (00184698)

Project Period (FY) 2001 – 2002
KeywordsCervical canal stenosis / Cervical OPLL / Cervical spondylotic myelopathy / MEG / Dipole / MRI / NCSS
Research Abstract

Objective evaluation of sensory dysfunction derived from chronic compressive disorders of the spinal cord is difficult. In the present study, the authors investigated the possibility of assessing cervical myelopathy-induced sensory disorders by using magnetoencephalography to measure somatosensory evoked magnetic fields.
In 7 patients with cervical myelopaty including cervical spondylotic myeloradiculopathy (n=4), cervical ossification of posterior longitudal ligament (n=2), and spinal dural arteriovenous fistula (n=1), somatosensory evoked magnetic fields were measured before and on the 7th day after surgery by using a 204-channel magnetoencephalography system (Neuromag) to stimulate the bilateral median nerve and the bilateral posterior tibial nerve, and the intensity and latency of N20m (first response occurring 20msec after stimulation) and P38m were then determined. The extensive laminoplasty at the level of C3-C6(C7) were performed, and the cord decompression was demonstrated with … More the postperative MRI study in all patients. Additionally, the severity of the sensory disorder was assessed before and after surgery by obtaining sensory scores determined using the Neurosurgical Cervical Spine Scale. Analysis of the results showed that the postoperative intensity of N20m in the 4 patients with cervical myelopathy was higher than that demonstrated preoperatively, and the postoperative latency in the same patients shortened compared with the preoperative study. In addition, of four patients in whom sensory scores improved remarkably after surgery, there were a correlation between sensory scores and dipole intensity. The period of symptoms in 3 patients with no change of the latency and intensity of N20m postoperatively was characteristically long, over 3 years.
Somatosensory evoked magnetic field measurements determined by magnetoencephalography are useful in objectively and noninvasively assessing sensory disorders caused by chronic compressed disorders of the spinal cord. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Masaya Iwakawa: "Intraspinal implants of fibrin glue containing glial cell line-derived neurotrophic factor promote dorsal root regeneration into spinal cord"Neurorehabilitation and Neural Repair. 15. 173-182 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ito: "Severe pulmonary hypertension in an infant with achondroplasia"Lancet. 358. 1062 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤康信: "小児脊髄混合腫瘍gliofibroma/pilocytic astrocytomaの1例"脊髄外科. 16. 171-178 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤康信: "難治性大後頭神経痛に対するC2神経節切除術"脊椎脊髄ジャーナル. 15. 1033-1036 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasunobu Itoh: "Spinal cord edema preceding syringomyelia Associated with Chiari I malformation -Case report-"Neurol Med Chir. 42. 410-413 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平野仁崇: "症候性仙骨神経根嚢腫の2手術例"脳神経外科ジャーナル. 12. 25-30 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasunobu Itoh: "Syringomyelia Current Concepts in Pathogenesis and Management"Springer-Verlag, Tokyo. 263 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwakawa,M: "Intraspinal implants of fibrin glue containing glial cell line-derived neurotrophic factor promote dorsal root regeneration into spinal cord."Neurorehabilitation and Neural Repair. 15. 173-182 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ito,M.: "Severe pulmonary hypertension in an infant with achondroplasia."Lancet. 358. 1062 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh,Y.: "Combined pilocytic astrocytoma and gliofibroma of the spinal cord: A report of a case."Spinal Surgery. 16. 171-178 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh,Y.: "C2 ganglionectomy for intractable greater occipital neuralgia."Spine & Spinal Cord. 15. 1033-1036 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh,Y.: "Spinal cord edema preceding syringe- Myelia associated with Chiari I malformation-Case report-"Neurologia medico-chirurgica. 42. 410-413 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirano,Y.: "Surgical treatment of symptomatic sacral perineural cyst: A report of two cases."Jpn. J. Neurosurg. 12. 25-30 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh,Y.: "Springer-Verlag, Tokyo"Syringomyelia Current Concepts in Pathogenesis and Management. 263 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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