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2002 Fiscal Year Final Research Report Summary

Pathogenesis and Acute Clinical-pathological Feature of Carotid Artery Stenosis and Occlusion

Research Project

Project/Area Number 13671424
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

ENDO Shunro  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (70125269)

Co-Investigator(Kenkyū-buntansha) HIRASHIMA Yutaka  Toyama Medical and Pharmaceutical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30135016)
HAMADA Hideo  Toyama Medical and Pharmaceutical University, University Hospital, Assistant Professor, 附属病院, 助手 (40272918)
Project Period (FY) 2001 – 2002
Keywordsatheroma-thrombus / carotid artery stenosis / carotid artery occlusion / plateletaggregation / heparincofactor II / clamidia pneumonia / heparin
Research Abstract

The purpose of this study is to approach pathogenesis and acute clinical-pathological feature of the carotid artery stenosis and occlusion. During 2 year research periods, the following three subjects were revealed as new evidence in this field, and important topics were reported in the journal
1 Clinico-pathological findings of chlamidia pneumonia of the carotid artery stenosis
2 Physiological and pathological mechanisms of heparin cofactor II
3 Monitoring of platelet aggregation and heparin activation in patients undergoing neuroendovascular treatment or angiography
Based on these studies, we continued research to investigate true pathological features of the carotid artery disease and to create the most adequate treatment selection and methods

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Hirashima Y, Endo S, et al.: "Chlamidia pneumonia infection is not involved in carotid artery Stenosis."Atherosclerosis. 163. 165-168 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayakawa Y, Endo S, et al.: "Contribution of basic residures of the A helix of heparin CofactorII to heparin- and dermatan sulfate.........."FEBS Letters. 522. 147-150 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 林 央周, 遠藤俊郎, 他: "頸動脈狭窄病変に対する外科治療の中期予後"脳卒中の外科. 30. 387-391 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 遠藤俊郎, 平島 豊, 他: "急性期脳虚血患者に対する緊急CEAの適応と手術の要点"脳神経外科ジャーナル. 11. 396-401 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayakawa Y, Endo S, et al.: "Mechanism of activation of heparin cofactor II by calcium spitulan"Arch Biochem Biophys. 416. 47-52 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirashima Y, Endo S, et al.: "Chlamidia pneumonia infection is not involved in carotid artery stenosis"Atherosclerosis. 163. 165-168 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayakawa Y, Endo S, et al.: "Contribution of basic residures of the A helix of heparin cofactor II to heparin-and dermatan sulfate"FEBS Letters. 522. 147-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi N, Endo 5, et al.: "Surgical outcome of the carotid artery stenosis"Cerebrovascular Surgery (in Japanese). 30. 387-391 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo S, Hirashima Y, et al.: "Surgical indication and technique of the carotid endarterectomy on emergency basis for ischemic stroke patients"Neurosurgical Journal (in Japanese). 11. 395-401 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayakawa Y, Endo S, et al.: "Mechanism of activation of heparin cofactor II by calcium spitulan"Arch Biochem Biophys. 415. 47-52 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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