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2002 Fiscal Year Final Research Report Summary

A NOVEL OF EXPERIMENTAL MODEL FOR CENTRAL CORD INJURY ON CHRONIC SPINAL CORD COMPRESSION MODEL OF RAT. RESEARCH FOR THE TIME OF DECOMPRESSION AND CLINICAL STUDY

Research Project

Project/Area Number 13671460
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionDOKKYO UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

KAWAMOTO Toshiki  SCHOOL OF MEDICINE, Assistant Professor, 医学部, 講師 (50301461)

Co-Investigator(Kenkyū-buntansha) ASAKUNO Keizo  SCHOOL OF MEDICINE, Instructor, 医学部, 助手 (00316548)
OGINO Masahiro  SCHOOL OF MEDICINE, Assistant Professor, 医学部, 講師 (80224137)
KIM Phyo  SCHOOL OF MEDICINE, Professor, 医学部, 教授 (90231290)
Project Period (FY) 2001 – 2002
Keywordschronic cord compression / spinal cord / neuronal loss / rat / central cord injury / microvascular anatomy / compression myelopathy / acute spinal injury
Research Abstract

A novel experimental model for central cord injury was not developed in the animal model. A thin expanding polymer was inserted under the cervical laminae without cord injury. We have studied the chronic spinal compression model of rat. We use the model of the rat; we tried studying the mechanism of central cord injury. In our model, the motor neuron count decreased in 9 weeks and 25 weeks significantly. The count of 25 weeks after compression was only 66% compared with control group. Then, the hyperextension of hyperflexion injury was given; a motor weakness of upper extremity will happen or not. Some of our model, there were the individual like a central cord injury. The fact will give us the possibility of central cord injury model of the rat. We also investigated the timing of decompression of the compressed spinal cord. At 8 to 12 weeks after compression (the time was the motor neuron count were decreased), if the decompression was not achieved, the capability of locomotion was not improved. In clinical, the fact suggested the timing of decompression surgery. We will continue the study of central cord injury using the model and clinical material. We believe the present model is to help advancement of the neuropathological and neurophysiological studies of the mechanism of central cord injury.

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Published: 2004-04-14  

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