2003 Fiscal Year Final Research Report Summary
Reconstruction of ligament using mesenchymal stem cells
| Project/Area Number |
13671489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gunma University |
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Principal Investigator |
TAKAGISHI Kenji Gunma Univ., Medicine, Professor, 医学部, 教授 (70154763)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOZAKI Tetsuya Gunma Univ., Medicine, Assistant Prof., 医学部, 講師 (90251115)
WATANABE Hideomi Gunma Univ., Medicine, Associate Prof., 医学部, 助教授 (40231724)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Mesenchymal stem cells / 靭帯 |
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| Research Abstract |
Mesenchymal stem cells harvested from the bone marrow are cultured in vitro and differentiated into the objected cells to repair the tissue defect. However, ligament tissue is hard to make. In this study, we tried to make the ligament tissue using stem cells. Stem cells were harvested from bone marrow in the rabbit and proliferated and embedded in the type I collagen gel. Stem cells secreted the type I collagen and present same character as the cells in the ligament. Cells differentiated into the cartilage cells showed the type II collagen.
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