2002 Fiscal Year Final Research Report Summary

Tumor growth inhibition and cancer prevention by serene enriched garlic in murine renal adenocarcinoma

Research Project

Project/Area Number	13671672
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Urology
Research Institution	IWATE MEDICAL UNIVERSITY SCHOOL OF MEDICINE
Principal Investigator	FUJIOKA Tomoaki IWATE MEDICAL UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF UROLOGY, PROFESSOR, 医学部, 教授 (80173409)
Project Period (FY)	2001 – 2002
Keywords	garlic / serene / renal cell carcinoma / apoptosis / anti-tumor effect
Research Abstract	Renca was inoculated in BALB/c mice subcutaneously or renalsubcapsularly. Various concentrations of garlic powder in saline were administered orally every two days until the day 21 and tumor volumes and weights examined, apoptosis induction in the treated tumor was also investigated by TUNEL method and RT-PCR as to Bax and bcl-2 mRNA expression. Furthermore, the concentrations of serene in tissues and sera in Renca bearing mice were measured by ICP-MS. Renca growth was inhibited and apoptosis was also induced in the tumors by treatment in a dose-dependent manner. Lower concentration of serene in tumor tisses and sera in tumor bearing mice could be correct by the garlic treatment. These finding may be important not only the treatment of renal cancer but also in its prevention