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2002 Fiscal Year Final Research Report Summary

The effect of umbilical cord occlusion on fetal cardiac function.

Research Project

Project/Area Number 13671697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

MARUMO Genzo  The University of Tokyo, Faculty of Medicine Department of Obstetrics and Gynecology, Research Associate, 医学部附属病院, 助手 (60282646)

Co-Investigator(Kenkyū-buntansha) FUJII Tomoyuki  The University of Tokyo, Faculty of Medicine Department of Obstetrics and Gynecology, Lecturer, 医学部附属病院, 講師 (40209010)
KAZUMA Shiro  The University of Tokyo, Faculty of Medicine Department of Obstetrics and Gynecology, Associate Professor, 医学部附属病院, 助教授 (10272569)
Project Period (FY) 2001 – 2002
Keywordscardiomegaly / fetm / brain damage
Research Abstract

It has been reported that fetal cardiac hypertrophy is closely related to perinatal brain damage. It is, therefore, important to clarify the relationship between fetal cardiac dysfunction and brain circulation to develop a new method of preventing the occurrence of cerebral palsy. The purpose of this study is to investigate the effect of umbilical cord occlusion on fetal cardiac function and brain blood flow in fetal sheep, because umbilical cord occlusions are known to cause fetal brain damage.
We inserted a conductance catheter into the left ventricle of the fetal heart under ultrasound guidance to record pressure-volume curves of the left ventricle of the fetal heart and to investigate the effect of complete umbilical cord occlusion on fetal cardiac function. In addition, we placed two probes of near-infrared. spectroscopy on both parietal bones to measure brain blood flow. Umbilical cord was completely occluded five times for 60 seconds, five times for 90 seconds and five times for 120 seconds.
Umbilical cord occlusions reduced stroke volume significantly throughout the experiments. During intervals of 90 seconds occlusion, fetal heart. contractility and cardiac output increased significantly compared with the control levels. However, stroke volume decreased significantly during intervals of 120 seconds occlusion. Petal brain blood flow gradually increased as repeated cord occlusions. It is speculated that these changes in fetal cardiac function and bruin circulation could be related to hypoxia, acidosis, and catecholamine secretion induce by repeated cord occlusions.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Hyodo HM, Kozuma S: "Mycardial hypertrophy of the recipient twins in twin-to-twin transfusion syndrome and cerebral palsy."Int J Gynaecol Obstet.. 80. 29-34 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kikuchi A, Marumo G: "Fractal tumor growth of ovarian cancer : sonographic evaluation."Gynecol Oncol.. 87. 295-302 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Zhang SQ, Fujii T: "Studies on fetal forelimb movements by using a wrist actigraph in sheep."Psychiatry Clin Neurosci.. 56. 283-284 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uemura H, Marumo G: "A movable gestational sac in association with a myometrial defect."Ultrasound Obstet Gynecol.. 18. 675-677 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroi H, Kozuma S: "Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder."Arch Gynecol Obstet.. 265. 228-230 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hyodo HM, Kozuma S: "Myocardial hypertrophy of the recipient twins in twin付o-twin transfusion syndrome and cerebral palsy."Int J Gynaecol Obstet. 80(1) January. 29-34 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kikuchi A, Marumo G: "Fractal tumor growth of ovarian cancer : sonographic evaluation."Gynecol Oncol.. 87(3) Dec.. 295-302 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zhang SQ, Fujii T: "Studies on fetal forelimb movements by using a wrist actigraph in sheep"Psychiatry Clin Neurosci. 56(3) Jun.. 283-284 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uemura H, Marumo G: "A movable gestational sac in association with a myometrial defect."Ultrasound Obstet Gynecol. 18(6) Dec.. 675-677 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroi H, Kozuma S: "Hypeiremesis gravidarum associated with thyrotoxicosis and a past history of aneating disorder."Arch Gynecol Obstet. 265(4) Nov.. 228-230 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida SH, Kozuma S: "Sonographic determination of fetal size from 20 weeks of gestation onward correlates with birth weight."J Obstet Gynaecol Res.. 27(4) Aug.. 205-211 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Lanai T, Fujii T: "Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion."Am J Reprod Immunol. 45(3) Mar.. 168-173 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanai T, Fujii T: "Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood."Am J Reprod Immunol. 45(2) Feb.. 94-99 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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