2002 Fiscal Year Final Research Report Summary
ANGIOGENIC FACTORS IN THE ENDOMETRIUM AND ENDOMETRIOSIS
| Project/Area Number |
13671699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OSUGA Yutaka THE UNIVERSITY OF TOKYO, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (80260496)
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| Project Period (FY) |
2001 – 2002
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| Keywords | angiogenesis / endometriosis / IP-10 / peritoneal fluid |
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| Research Abstract |
Problem : To assess whether interferon-g-induced protein-10 (IP-10), a chemokine that has antiangiogenic activities, may be involved in the pathogenesis of endometriosis.
Method of Study : One-hundred and twenty patients undergoing laparoscopy for pain and / or infertility were recruited, and peritoneal fluid (PF) and bone marrow derived cells in PF were collected. Concentrations of IP-10 in PF were measured with a specific enzyme-linked immunosorbent assay. Expression of IP-10 and IP-10 receptor, CXCR3, in bone marrow derived cells in PF, peritoneum and endometriotic cells was analyzed by reverse transcription-polymerase chain reaction.
Results : All of the PF samples examined contained detectable concentrations of IP-10. In women with advanced stages of endometriosis, IP-10 concentrations in PF were significantly lower than those of women with early stages (p=0.02). The IP-10 concentrations in women with advanced endometriosis also appeared to be lower than those without endometriosis although the difference was statistically marginal (p=0.06) The expression of both IP-10 and CXCR3 was clearly detected in the bone marrow derived cells in PF, peritoneum and endometriotic stromal cells.
Conclusions : Decreased concentrations of IP-10 in PF from women with advanced stages of endometriosis may imply that the peritoneal environment of these women is permissive to the development of the disease by enhancing angiogenesis and/or modulating inflammatory/immunological responses.
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[Publications] Fujimoto A, Osuga Y, Fujiwara T, Yano T, Tsutsumi O, Momoeda M, Kugu K, Koga K, Morita Y, Wada O, Taketani Y.: "Human Chorionic Gonadotropin Combined with Progesterone for Luteal Support Improves Pregnancy Rate in Patients with Low Late-Midluteal Estradiol Levels in IVF Cycles"J Assist Reprod Genet. 19. 550-554 (2002)
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[Publications] Momoeda M, Taketani Y, Terakawa N, Hoshiai H, Tanaka K, Tsutsumi O, Osuga Y, Maruyama M, Harada T, Obata K, Hayashi K: "Is eridometriosis really associated with pain?"Gynecol Obstet Invest. 54 Suppl 1. 18-23 (2002)
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[Publications] Tang X, Yano T, Osuga Y, Matsumi H, Yano N, Xu J, Wada O, Koga K, Kugu K, Tsutsumi O, Schally AV, Taketani Y.: "Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasing hormone antagonist Cetrorelix"J Clin Endocrinol Metab. 87. 3721-3727 (2002)
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[Publications] Xu J, Osuga Y, Yano T, Morita Y, Tang X, Fujiwara T, Takai Y, Matsumi H, Koga K, Taketani Y, Tsutsumi O.: "Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells"Biochem Biophys Res Commun. 292. 456-462 (2002)
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