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2002 Fiscal Year Final Research Report Summary

ANGIOGENIC FACTORS IN THE ENDOMETRIUM AND ENDOMETRIOSIS

Research Project

Project/Area Number 13671699
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

OSUGA Yutaka  THE UNIVERSITY OF TOKYO, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (80260496)

Project Period (FY) 2001 – 2002
Keywordsangiogenesis / endometriosis / IP-10 / peritoneal fluid
Research Abstract

Problem : To assess whether interferon-g-induced protein-10 (IP-10), a chemokine that has antiangiogenic activities, may be involved in the pathogenesis of endometriosis.
Method of Study : One-hundred and twenty patients undergoing laparoscopy for pain and / or infertility were recruited, and peritoneal fluid (PF) and bone marrow derived cells in PF were collected. Concentrations of IP-10 in PF were measured with a specific enzyme-linked immunosorbent assay. Expression of IP-10 and IP-10 receptor, CXCR3, in bone marrow derived cells in PF, peritoneum and endometriotic cells was analyzed by reverse transcription-polymerase chain reaction.
Results : All of the PF samples examined contained detectable concentrations of IP-10. In women with advanced stages of endometriosis, IP-10 concentrations in PF were significantly lower than those of women with early stages (p=0.02). The IP-10 concentrations in women with advanced endometriosis also appeared to be lower than those without endometriosis although the difference was statistically marginal (p=0.06) The expression of both IP-10 and CXCR3 was clearly detected in the bone marrow derived cells in PF, peritoneum and endometriotic stromal cells.
Conclusions : Decreased concentrations of IP-10 in PF from women with advanced stages of endometriosis may imply that the peritoneal environment of these women is permissive to the development of the disease by enhancing angiogenesis and/or modulating inflammatory/immunological responses.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Fujimoto A, Osuga Y, et al.: "Human Chorionic Gonadotropin Combined with Progesterone for Luteal Support Improves Pregnancy Rate in Patients with Low Late-Midluteal Estradiol Levels"J Assist Reprod Genet.. 19・12. 550-554 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto A, Osuga Y, et al.: "Ovarian hyperstimulation syndrome complicated by peritonitis due to perforated appendicitis"Hum Reprod. 17・4. 966-967 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroi H, Osuga Y, et al.: "A case of estrogen-producing brenner tumor with a stromal component as a potential source for estrogen"Oncology. 63. 201-204 (2002)

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      「研究成果報告書概要(和文)」より
  • [Publications] Osuga Y, Yano T, et al.: "Effects of gonadotropin-releasing hormone analog treatment on skin condition"Gynecol Endocrinol. 16. 57-61 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Osuga Y, koga K, et al.: "Role of laparoscopy in the treatment of endometriosis-associated infertility"Gynecol Obstet Invest. 53・Suppl 1. 33-39 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Xu J, Osuga Y, et al.: "Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells"Biochem Biophys Res Commun. 292・2. 456-462 (2002)

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      「研究成果報告書概要(和文)」より
  • [Publications] Fujimoto A, Osuga Y, Fujiwara T, Yano T, Tsutsumi O, Momoeda M, Kugu K, Koga K, Morita Y, Wada O, Taketani Y.: "Human Chorionic Gonadotropin Combined with Progesterone for Luteal Support Improves Pregnancy Rate in Patients with Low Late-Midluteal Estradiol Levels in IVF Cycles"J Assist Reprod Genet. 19. 550-554 (2002)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Momoeda M, Taketani Y, Terakawa N, Hoshiai H, Tanaka K, Tsutsumi O, Osuga Y, Maruyama M, Harada T, Obata K, Hayashi K: "Is eridometriosis really associated with pain?"Gynecol Obstet Invest. 54 Suppl 1. 18-23 (2002)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Kurosawa T, Hiroi H, Tsutsumi O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y.: "The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type"Endocr J. 49. 465-471 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimoto A, Osuga Y, Yano T, Kusumi M, Kurosawa T, Fujii T, Taketani Y.: "Ovarian hyperstimulation syndrome complicated by peritonitis due to perforated appendicitis Case Report"Hum Reprod. 17. 966-967 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroi H, Osuga Y, Tarumoto Y, Shimokama T, Yano T, Yokota H, Taketani Y.: "A case of estrogen-producing brenner tumor with a stromal component as a potential source for estrogen"Oncology. 63. 201-204 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Osuga Y, Yano T, Kugu K, Koga K, Fukuoka K, Matsumi H, Wada O, Kikuchi A, Tsutsumi O, Taketani Y.: "Effects of gonadotropin-releasing hormone analog treatment on skin condition"Gynecol Endocrinol. 16. 57-61 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Osuga Y, Koga K, Tsutsumi O, Yano T, Maruyama M, Kugu K, Momoeda M, Taketani Y.: "Role of laparoscopy in the treatment of eridometriosis-associated infertility"Gynecol Obstet Invest. 53 Suppl 1. 33-39 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tang X, Yano T, Osuga Y, Matsumi H, Yano N, Xu J, Wada O, Koga K, Kugu K, Tsutsumi O, Schally AV, Taketani Y.: "Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasing hormone antagonist Cetrorelix"J Clin Endocrinol Metab. 87. 3721-3727 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Xu J, Osuga Y, Yano T, Morita Y, Tang X, Fujiwara T, Takai Y, Matsumi H, Koga K, Taketani Y, Tsutsumi O.: "Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells"Biochem Biophys Res Commun. 292. 456-462 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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