2002 Fiscal Year Final Research Report Summary
POLYMORPHISMS ASSOCIATED WITH ENDOMETRIOSIS
| Project/Area Number |
13671736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
KITAWAKI Jo KYOTO PREF. UNIV . MED, MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (00204925)
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| Project Period (FY) |
2001 – 2002
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| Keywords | ENDOMETRIOSIS / POLYMORPHISM / ESTROGEN RECEPTOR / AROMATASE / INTERLEUKIN-10 / HLA |
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| Research Abstract |
Endometriosis is defined by the presence of endometrial glands and stroma outside of the uterine cavity. Although its exact etiology and pathogenesis are unclear, the growth of endometriosis is estrogen-dependent. Studies have implied a role for genetic factors in the association between the development of endometriosis and genetic polymorphisms
A single nucleotide polymorphism in intron 1 of the ER-α gene and a 3-base pair insertion/deletion polymorphism in intron 4 of the CYP 19 gene encoding P450arom are associated with the susceptibility of endometriosis in a Japanese population
Interleukin-10 promoter polymorphisms were associated with the production of autoantibodies to carbonic anhydrase II in patients with endometriosis
Finally, we investigated the frequencies of HL-A-A, -B, -C and -DRB1 antigens or alleles in the patients with endometriosis and healthy control women. Significant positive association with endometriosis was observed for HLA-B7 and for Cw^*0702. Our results indicated that the HLA-A24-B^*0702-Cw^*0702-DRB1^*0101 haplotype was associated with endometriosis susceptibility
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