2002 Fiscal Year Final Research Report Summary
A human monoclonal antibody (10-9D) that selectively recognizes human uterine endometrial carcinoma
| Project/Area Number |
13671745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
TSUKAZAKI Katsumi Keio University, School of Medicine, Associate Professor, 医学部, 助教授 (40118972)
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| Project Period (FY) |
2001 – 2002
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| Keywords | human monoclonal antibody / cross-bred trans-chemosomic mouse / human endometrial carcinoma / 免疫組織化学染色 |
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| Research Abstract |
Our newly established human monoclonal antibody termed 10-9D (of IgM subclass) was found to recognized human uterine endometrial cancer carcinoma. Immunohistochemical staining revealed that the reactivity of 10-9D was position in 54.6% of uterine endometrial adenocarcinoma specimens furthermore , the monoclonal antibody does not react with either proliferative or secretory phase normal endometrium. Although slight positivity was observed in the epithelium of the collecting duct in the kidney and gallbladder, no staining was observed in a wide variety of other normal and malignant tissues. Carbohydrate analysis determined that the epitope structure for this antibody is a disulfated mucin-type Olinked carbohydrate structure. These characteristics implicate a possible future diagnostic as well as therapeutic role using the antibody
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[Publications] Kyoko,Takehara, Kaneyuki,Kubushiro, Yuriko,Iwamori, Katsumi,Tsukazaki, Shiro,Nozawa, Masao,Iwamori: "Expression of an isoform of the testis-specific estrogen sulfotransferase in the rine placenta during the late gestational period."Arch. Biochem. Biophys. 394(2). 201-208 (2001)
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[Publications] Hiroyuki,Nakagawa, Kokichi,Sugano, Takuma,Fujii, Kaneyuki,Kubushiro, Katsumi,Tsukazaki, Shiro,Nozawa: "Frequent detection of human papilloma viruses in cervical dysplasia by PCR single-strand DNA-conformational polymorphism Analysis."Anticancer Research. 22. 1655-1660 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Kyoko,Takehara, Kaneyuki,Kubushiro, Isamu,Ishikawa, Katsumi,Tsukazaki, Shiro,Nozawa, Masao,Iwamori: "Expression of glycolipids bearing Lewis phenotypes in tissues and cultured cells of human gynecological cancers."Jpn. J. Cancer Res.. 93. 1129-1137 (2002)
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「研究成果報告書概要(欧文)」より
