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2002 Fiscal Year Final Research Report Summary

STRATEGY OF GENE THERAPY AGAINST OVARIAN CANCER BY USING HGF ANTAGONIST(HGF/NK4)

Research Project

Project/Area Number 13671754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

YONEYAMA Koichi  NIPPON MEDICAL SCHOOL, DEPT. OF OB OB/GY ASSOCIATE PROFESSOR, 医学部, 講師 (90220772)

Co-Investigator(Kenkyū-buntansha) KUROSE Keisuke  NIPPON MEDICALSCHOOL, DEPT. OF OB OB/GY, INSTRUCTOR, 医学部, 助手
Project Period (FY) 2001 – 2002
KeywordsOVARIAN CANCER / HGF (HEPATOCYIE GROWTH FACTOR)
Research Abstract

TO OUR REGRET, IT WAS IMPOSSIBLE TO MAKE EFFECTIVE ADENOVIRAL VECTOR CONTAINING NK4 WHICH IS ANTAGONIST OF HGF (HEPATOCYTE GROWTH FACTOR). SO, WE COULD NOT HELP CHANGING THE PROJECT. IN THIS STUDY, WE INVESTIGATED THE SERUM HGF LEVELS OF THE PATIENTS WITH VARIOUS OVARIAN TUMORS. [MATERIALS AND METHODS] THE BLOOD SAMPLES WERE OBTAINED FROM THE THIRTEEN PATIENTS WITH OVARIAN CANCERS, EIGHT PATIENTS WITH BENIGN OVARIAN TUMORS AND TEN NORMAL VOLUNTEERS. THE SERUM HGF LEVELS WERE DETERMINED BY ELIZA METHODS. INFORMED CONCENTS WERE OBTAINED BY ALL PEARSONS. [RESULTS] THE SERUM HGF LEVEL WAS 0.59 ± 0.38 IN YHE PATIENTS WITH OVARIAN CANCERS, 0.39 ± 0.17 IN YHE PATIENTS WITH BENIGN OVARIANTUMORS AND 0.32 ± 0.06 IN THE NORMAL VOLUNTEERS. THE SERUM HGF LEVEL IN YHE PATIENTS WITH OVARIAN CANCERS WAS CLEARLY HIGHER THAN THAT IN THE NORMAL VOLUNTEERS (P=0.002) THER WAS NO DIFFERENCE BETWEEN THE SERUM HGF LEVEL IN YHE PATIENTS WITH BENIGN OVARIAN TUMORS AND THAT IN THE NORMAL VOLUNTEERS (P=0.25). [CONCULUSION] THE SERUM HGF LEVEL CAN BE ONE OF THE USEFUL MARKER FOR THE OVARIAN CANCER SCREENING.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 沖野恵子, 米山剛一, 他: "良性および悪性卵巣腫瘍におけるチミヂンホスフォリラーゼの発現動態の検討"日本産科婦人科学会雑誌. 54. 494 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 米山剛一, 他: "婦人科悪性腫瘍術後の血栓症発症因子に関する臨床的検討"産婦人科の実際. 52(印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OKINO K, YONEYAMA K, ET AL: "ANALYSIS OF LEVELS OF THYMIDINE PHOSPHOLYRASE IN BENIGN AND MALIGNANT OVARIAN TUMORS"ACIA OBSTE JYNAEC JPN. 54. 494 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YONEYAMA K, ET AL: "RISK FACTORS OF POST OPERATIVE THROMBOEMBOLISM IN GYNECOLOGIC MALIGNANCIES."SANFUJINKA NO JISSAI. 52 IN PRESS. (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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