2002 Fiscal Year Final Research Report Summary
Effect of ions on in vitro mineral induction by dentin matrix
| Project/Area Number |
13672007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
TOYOOKA Hiroki Health Sciences University of Hokkaido, School of Dentistry, Department of Operative Dentistry and Endodontology, Instructor, 歯学部, 助手 (30285530)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takashi Health Sciences University of Hokkaido, School of Dentistry, Department of Operative Dentistry and Endodontology, Assistant Professor, 歯学部, 講師 (40265070)
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| Project Period (FY) |
2001 – 2002
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| Keywords | dentin / mineral induction / ion |
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| Research Abstract |
The effect of ions that could be released from restorative materials on the mineralization of dentin are not known. Restorative material contains fluoride, silicate, calcium, phosphate, and sometimes magnesium, and silver at well. We examined the effects of various ions on mineralization of dentin matrix in vitro. Demineralized dentin matrix was incubated in metastable calsium phosphate solution with or without silicate, fluoride, calcium, phosphate, magnesium or silver. In soluble dentin matrix induced mineral fomation in metastable solution without added ions. Silicate and fluoride significantly reduced mineral induction by insoluble dentin matrix. At least calcium or phosphate was required to promote mineral induction. Conversely, magnesium and silver inhibited mineral induction. The mineral induced by each sample after incubation for 24h was identified by its X-ray diffraction pattern as apatite. We conclude that silicate is a stronger inducer of remineralization of dentin matrix than fluoride, calcium or phosphate, and that magnesium and silver inhibit the induction of mineralization of dentin matrix.
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