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2002 Fiscal Year Final Research Report Summary

A Study on the intravenous sedation with propofal - BIS monitor and blood concentration of propofol

Research Project

Project/Area Number 13672095
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

SHIMADA Masahiko  Okayama University Graduate School of Medicine and Dentistry Professor, 大学院・医歯学総合研究科, 教授 (40170948)

Project Period (FY) 2001 – 2002
KeywordsIntravenous sedation / Propofal / BIS monitor / Blood concentration / Equilibrium Function / Intellectual Disability / Dental treatment
Research Abstract

1.Twelve healthy volunteers who received intravenous administration of propofol at a dose of 6mg/kg/h for 5min. And 3mg/kg/h for 85min. Were evaluated sedative effect using BIS monitor and tested qualitatively and quantitatively for their equilibrium function. The values of BIS were correlated with sedation scores during the study. The recovery of equilibrium function were not complete though the value of BIS were normal.
2.To investigate the usefulness of BIS monitor during intravenous sedation, ten patients with intellectual disability were evaluated sedative effect using BIS monitor during dental treatment under intravenous sedation with propofol. The values of BIS after dental treatment were correlated with recovery time.
The results of study suggest that BIS monitor is very useful to evaluate the sedative effect under the intravenous sedation with propofol during the dental treatment.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 北 ふみ: "高速液体クロマトグラフィーを用いた血中プロポフォールの測定について"岡山歯学会雑誌. 21(2). 191-194 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北 ふみ: "静脈内鎮静法におけるプロポフォールの投与方法の検討"岡山歯学会雑誌. 21(2). 195-200 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北 ふみ: "プロポフォールを用いた静脈内鎮静法の回復過程の検討"岡山歯学会雑誌. 22(1)(印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumi KITA: "Determination of propofol in blood by HPLC"The Journal of Okayama Dental Society. 21(2). 191-194 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumi KITA: "A Study of Medication under intravenous Sedation with Propofol"The Journal of Okayama Dental Society. 21(2). 195-200 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumi KITA: "A Study on Recovery from intravenous Sedation with Propofol"The Journal of Okayama Dental Society. 22(1) In press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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