Study on bone regeneration using an absorbable osteoconductive material with a jungle gym structure

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 13672096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yamaguchi University (2002-2003); Okayama University (2001)
• Principal Investigator: MANO Takamitsu Yamaguchi University, School of Medicine, Assistant Professor, 医学部, 講師 (80325125)
• Co-Investigator(Kenkyū-buntansha): KASAI Teruo Okayama University, Dental Hospital, Research Associate, 歯学部附属病院, 助手 (00335613) ; ISHIKAWA Kunio Kyushu University, Faculty of Dental Science, Professor, 大学院・歯学研究院, 教授 (90202952) ; UEYAMA Yoshiya Yamaguchi University, School of Medicine, Professor, 医学部, 教授 (00168668)
• Project Period (FY): 2001 – 2003
• Keywords: poly lactic acid / osteoconductive material / absorbable / bone regeneration

Research Abstract

We could make a poly lactic acid (PLLA) sheet having a pore by dissolving with a solvent. Furthermore, we could adhere hydroxyapatite (HA) powder on the surface of the PLLA by a solvent
A bicortical bone defect in the tibia of the rat was made. The bone defect was covered with PLLA sheet or PLLA sheet adhering HA powder. The rats were killed at 1,2 and 4 weeks after surgery. The tibia was excised with surrounding tissue. Sections were prepared and were stained with hematoxylin-eosin for light microscopy. Consequently, we found that the defect was restored to nealy original condition. In the case of PLLA sheet adhering HA powder, the result was the same of PLLA sheet. A few inflammatory reaction was observed during the experimental periods. PLLA was not resorbed at four weeks after implantation
In conclusion, we found that PLLA sheet functioned effectively as a GBR membrane