2002 Fiscal Year Final Research Report Summary

Study of Angiostatin Genetherapy for Oral Cancer

Research Project

Project/Area Number	13672127
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Kanagawa Dental College
Principal Investigator	USHAKU Lee Kanagawa Dental College, Oral Surgery, Assistant, 歯学部, 助手 (90288085)
Co-Investigator(Kenkyū-buntansha)	OHMI Yasushi Kanagawa Dental College, Oral Surgery, Assistant, 歯学部, 助手 (10318892) MATSUMOTO Goichi Kanagawa Dental College, Oral Surgery, Instructor, 歯学部, 講師 (60199867)
Project Period (FY)	2001 – 2002
Keywords	Angiostatin / Oral Cancer / Gene Therapy / Angiogenesis
Research Abstract	Antiangiogenic tumor therapies have recently attracted intense interest because of their direct endothelial targeting and the absence of drug resistance. To achieve tumor regression and tumor dormancy, antiangiogenic agents need to be administered. Local antiangiogenic gene therapy for cancer offers a potential way to achieve sustained therapeutic release of antiangiogenic substances. As a step toward this goal, we used liposomes complexed to angiostatin cDNA and targeted to human squamous cell carcinoma cell lines in vivo. Tumor cells expressing angiostatin after local gene transfer showed markedly reduced vascularity and contained many apoptotic tumor cells. These results demonstrate the potential utility of liposome-derived angiostatin for adjuvant therapy of oral cancer in humans.