2002 Fiscal Year Final Research Report Summary
Chemoenzymatic synthesis of N-acetylneuraminic acid derivatives and their behaviour towards sialidase from human parainfluenza virus
| Project/Area Number |
13672223
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
IKEDA Kiyoshi University of Shizuoka, School of Pharmaceutical Sciences Associate Professor, 薬学部, 助教授 (40168125)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | sialic acid / parainfluenza sialidase / sialidase inhibitor / hybrid-process / 2-deoxy-2, 3-dehydro-sialic acid / 2, 2-difluorosialic acid derivatives |
|---|
| Research Abstract |
Human parainfluenza virus is an important human pathogen causing upper and lower respiratory disease. To explore the influence on binding to sialidase from hPIV-1, modification of the hydroxyl group at the C-4 in 2β, 3β-difluorosialic acid derivatives and Neu5Ac2en derivatives was carried out. Synthesized compounds showed inhibitory activities against hPIV-1.
|
-
-
-
-
-
-
-
-
[Publications] Takashi Suzuki., Kiyoshi Ikeda., Noriko Koyama., Chika Hosokawa., Toshihiro Kogure., Tadanobu Takahashi., Kazuya I. -P Jwa Hidari., Daisei Miyamoto., Kiyoshi Tanaka., and Yasuo Suzuki.: "Inhibition of Human Parainfluenza Virus Type 1 Sialidase by Analogs of 2-Deoxy-2, 3-didehydro-N-acetylneuraminic Acid"Glycoconjugate J.. 18. 331-337 (2001)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
