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2003 Fiscal Year Final Research Report Summary

Studies on Functional Regulation in Endogenous Regucalcin, An Intracellular Calcium Signaling Regulatory Protein, in Regucalcin Transgenic Rats

Research Project

Project/Area Number 13672292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

YAMAGUCHI Masayoshi  University of Shizuoka, Grauduate School of Nutritional and Environmental Sciences, Professor, 大学院・生活健康科学研究科, 教授 (70046308)

Project Period (FY) 2001 – 2003
Keywordsregucalcin / transgenic rats / osteoporosis / hyperlipidemia / 高アルブミン血症 / 高脂血症
Research Abstract

Regucalcin, which was discovered by Yamaguchi as a calcium-binding protein in 1978 years, has endogenous regucalcin was investigated by using regucalcin transgenic (RC-Tg) rats. The body weight of RC-Tg rats was significantly suppressed with increasing age. Endogenous regucalcin was markedly expressed in the organ tissues of the Tg rats. Especially, its expression was remarkable in the female rats rather than male rats, because the regucalcin gene is localized on chromosome X. The role of regucalcin in the regulation of cellular functions, which were found in normal rats, was also demonstrated in the organ tissues of RC-Tg rats. Bone loss was found to induce in the femoral tissues of RC-Tg rats with increasing age. This was based on stimulation of osteoclastic bone resorption. Regucalchin had a stimulatory effect on osteoclastic cell formation from bone marrow cells. Futhermore, hyperlipidemia was found to induce in RC-Tg rats with increasing. Also, a significant increase in serum albumin was induced in RC-Tg rats. RC-Tg rats were usfull as rat model for osteoporosis and hyperlipidemia with increasing age.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Yamaguchi M 他: "Role of endogenous regucalcin in bone metabolism : Bone loss is induced in regucalcin transgenic rats."International Journal of Molecular Medicine. 10. 377-383 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi M 他: "Role of endogenous regucalcin in transgenic rats : Suppression of kidney cortex cytosolic protein phosphatase..."Journal of Cellular Biochemistry. 86. 520-529 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsurusaki Y.Yamaguchi M: "Role of endogenous regucalcin in transgenic rats : Suppression of protein tyrosine phosphatase and ribonucleic."International Journal of Molecular Medicine. 12. 207-211 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ma ZJ, Yamaguchi M: "Regulatory effect of regucalcin on nitric oxide synthase activity in rat kidney cortex cytosol : Role of..."International Journal of Molecular Medicine. 12. 201-206 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tobisawa M.Yamaguchi M: "Role of endogenous regucalcin in brain function : Suppression of cytosolic nitric oxide synthase and..."International Journal of Molecular Medicine. 12. 581-585 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi M. 他: "Expression of regucalcin in rat bone marrow cells : Involvement of osteoclastic bone resorption in..."International Journal of Molecular Medicine. 13. 437-443 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi M: "Role of endogenous regucalcin in transgenic rats : Suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca^<2+>-ATPase activity."Journal of Cellular Biochemistry. 86. 520-529 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi M, Takahashi H, Tsurusaki Y: "Suppressive role of endogenous regucalcin in the enhancement of nitric oxide synthase activity in liver cytosol of normal and regucalcin transgenic rats."Journal of Cellular Biochemistry. 88. 1226-1234 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsurusaki Y, Yamaguchi M: "Role of endogenous regucalcin in transgenic rats : Suppression of protein tyrosine phosphatase and ribonucleic acid synthesis activities in liver nucleus."International Journal of Molecular Medicine. 12. 207-211 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ma ZJ, Yamaguchi M: "Regulatory effect of regucalcin on nitric oxide synthase activity in rat kidney cortex cytosol : Role of endogenous regucalcin in transgenic rats."International Journal of Molecular Medicine. 12. 201-206 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichikawa E, Tsurusaki Y, Yamaguchi M: "Suppressive effect of regucalcin on protein phosphatase activity in the heart cytosol of normal and regucalcin transgenic rats."International Journal of Molecular Medicine. 13. 289-293 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ma ZJ, Yamaguchi M: "Suppressive role of endogenous regucalcin in the regulation of nitric oxide synthase activity in heart muscle cytosol of normal and regucalcin transgenic rats."International Journal of Molecular Medicine. 10. 761-766 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tobisawa M, Yamaguchi M: "Role of endogenous regucalcin in brain function : Suppression of cytosolic nitric oxide synthase and nuclear protein tyrosine phosphatase activities in brain tissue of transgenic rats."International Journal of Molecular Medicine. 12. 581-585 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi M, Misawa H, Uchiyama S, Morooka Y, Tsurusaki Y: "Role of endogenous regucalcin in bone metabolism : Bone loss is induced in regucalcin transgenic rats."International Journal of Molecular Medicine. 10. 377-383 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi M, Sawada N, Uchiyama S, Misawa H, Ma ZJ: "Expression of regucalcin in rat bone marrow cells : Involvement of osteoclastic bone resorption in regucalcin transgenic rats."International Journal of Molecular Medicine. 13. 437-443 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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