2002 Fiscal Year Final Research Report Summary
Evaluation and improvement for poor bioavailability of aminoglycosides in the intestinal tract after oral administration
| Project/Area Number |
13672330
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
医薬分子機能学
|
|---|
| Research Institution | Department of Pharmacokinetics, Kyoto Pharmaceutical University |
|---|
Principal Investigator |
HAKADA Kanji Kyoto Pharmaceutical University Department of Pharmacokinetics Professor, 薬物動態, 教授 (30102106)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Yukako Kyoto Pharmaceutical University Department of Pharmacokinetics Associate Professor, 薬物動態, 助手 (30278444)
SHIBATA Nobuhito Kyoto Pharmaceutical University Department of Pharmacokinetics Associate Professor, 薬物動態, 助教授 (60319449)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | Glycopeptides / Labrasol / Vitamine E TPGS / Vancomycin / Gentamicin / Bioavailability / LC-MS-MS / Pharmacokinetics |
|---|
| Research Abstract |
We evaluated the mechanisms for poor permeability of aminoglycosides, vancomycin (VCM) and gentamicin (GM) in rats, and developed pharmaceutics of VCM and GM using an active surfactant, Labrasol. In addition, we developed a high sensitive LC/MS/MS method to determine VCM in plasma. The bioavailability of GM in self-micro-emulsifying drug delivery system (SMEDDS) using Labrasol increased by 50-100 folds as compared with a standard solution without Labrasol. The SMEDDS for VCM prepared by Labrasol and vitamin E TPGS at a weight ratio of 4:1 or addition of Eudragit also provided marked improvement in the VCM bioavailability after oral administration.
|
