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2003 Fiscal Year Final Research Report Summary

Studies of data-collecting strategies for the literature database on diagnostic characteristics of laboratory examination and structural design of the database

Research Project

Project/Area Number 13672436
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionYamaguchi University

Principal Investigator

ISHIDA Haku  Yamaguchi University, Hospital Department of Medical Informatics and Decision Sciences, Assistant professor, 医学部附属病院, 講師 (50176195)

Co-Investigator(Kenkyū-buntansha) NISHIBORI Masahiro  Tokyo Medical and Dental University, Hospital Faculty of Medicine, Research associate, 医学部附属病院, 助手 (60189305)
MIYAKE Kazunori  Juntendo University, School of Medicine, Research associate, 医学部, 助手 (30190747)
KITAMURA Kiyoshi  University of Tokyo, International Research Center for Medical Education, Professor, 医学教育国際協力研究センター, 教授 (10186265)
MATSUNO Youko  Beckam Research Institute of City of Hope, Department of Biology, Research fellow, Dept・ of Biology, Research fellow (60229515)
Project Period (FY) 2001 – 2003
KeywordsEvidence-Based Medicine / Laboratory Medicine / Database / Systematic Review / Literature Search
Research Abstract

The search strategy in identification of the articles related to diagnostic accuracy and a structure of database were investigated for performing systematic review in laboratory medicine efficiently
When retrieval of article from MEDLINE was performed to identify articles listed in published systematic reviews, the rate of identification of them varied greatly according to the difference in usage of keyword such as MeSH, subheading term or text words. Therefore, in systematic review, in order to perform highly sensitive search without an overlooking, careful thinking for combination of searching terms such as "sensitiv*", "specificit*", "diagnos*" and nomenclature of diagnostic test itself was required based on the result of retrieval investigated by Haynes and others. Moreover, as the structure of a database for systematic review, the database consisting of the following components was considered as suitable : literature information of primary articles, information about summary of sys … More tematic review, additional information on the quality and external validity of literature, diagnostic accuracy, and index information such as MeSH
Based on the database structure, knowledge database with Web interface was developed in order to perform systematic reviews efficiently and continuously through collaborative actions by researchers and the following functions were mounted : 1) displaying articles that have been appraised critically ; 2) a page for registration of literature information of study reports on the database and a page for critical appraisal ; 3) a page for entry of diagnostic characteristics and a function of automatic calculation of confidential intervals ; 4) an input/output page for group-based systematic review ; 5) extraction of information for meta-analyses and graphs (Forest plot and summary ROC curves) : and 6) a page for registration of unpublished studies and a page for editing abstracts. Moreover, the check list for critical appraisal was improved according to the differences between the previous one and other tools such as STARD initiative
Members of our study group and other collaborative reviewers entered data into this database to evaluate the integrity of the system and reported the system Less

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 石田 博: "診断検査についてのEvidenceの収集を目指したWebベースシステムの構築"医療情報学. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石田 博: "EBLMの進め方と問題点-系統的レビューを中心に-(4)課題選択と文献検索の手法"臨床病理. 51・7. 682-690 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 竹村 譲: "EBLMの進め方と問題点-系統的レビューを中心に-(6)特別発言-高感度CRP系統的再評価における問題点-"臨床病理. 51・7. 696-699 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuzuru Takemura: "High-Sensitivity C-Reactive Protein : Applications to Pediatrics"Lab Medica International. Jan-Feb. 10-12 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石田 博: "系統的再評価の一事例:新生児感染症診断におけるCRP検査"臨床病理. 49・10. 1020-1029 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石田 博: "診断検査における系統的再評価の手法"臨床化学. 30・4. 253-264 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Haku Ishida: "Construction of a Web-based system that collects and provides essential information from diagnosis-related articles"Japan Journal of Medical Informatics. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Haku Ishida: "Searching for primary studies for inclusion in systematic reviews"Rinsho Byori. 51-7. 682-690 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuzuru Takemura: "Problems in systematic review for diagnostic accuracy of high-sensitivity C-reactive protein assay in neonatal infection"Rinsho Byori. 51-7. 696-699 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuzuru Takemura: "High-sensitivity C-reactive protein : Applications to pediatrics"Lab Medica International. Jan-Feb. 10-12 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Haku Ishida: "A systematic review for the diagnostic accuracy of serum C-reactive protein measurement in neonatal infants with infection"Rinsho Byori. 49-10. 1020-1029 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Haku Ishida: "Method for systematic reviews of diagnostic tests"Rinsho Kagaku. 30-4. 253-264 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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