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2003 Fiscal Year Final Research Report Summary

Management of chronic liver diseases with polyunsaturated fatty acids and anti-oxidative food substance

Research Project

Project/Area Number 13680156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 食生活
Research InstitutionOkayama Prefectural University

Principal Investigator

OKITA Misako  Okayama Prefectural University, Faculty of Health and Welfare Science, Professor, 保健福祉学部, 教授 (70079242)

Co-Investigator(Kenkyū-buntansha) SUZUKI Kazuhiko  Kurashiki Sakuyo University, Faculty of Food Culture, Professor, 食文化学部, 教授 (50035490)
YASUKO Ota  Okayama Prefectural University, Faculty of Health and Welfare Science, Assistant, 保健福祉学部, 助手 (90326413)
SASAGAWA Takayo  Okayama Prefectural University, Faculty of Health and Welfare Science, Assistant Professor, 保健福祉学部, 講師 (10254567)
YAMADA Gotaro  Kawasaki Medical School, Kawasaki Hospital, Center for Liver Diseases, Chief of Center, 肝臓・消化器病センター, センター長
Project Period (FY) 2001 – 2003
Keywordspolyunsaturated fatty acid / arachidonic acid / eicosapentaenoic acid / vitamin E / oxidative stress / cytokine / erythrocyte / liver cirrhosis / chronic hepatitis / food intake
Research Abstract

1.To elucidate the significance of arachidonic acid deficiency on the clinical pathophysiology of liver cirrhosis, fatty acid composition of mononuclear cells, plasma α-tocopherol and TBARS and serum TNF-α were analyzed. Significantly low level of arachidonic acid and EPA were observed in mononuclear cell phospholipids, and the arachidonic acid level correlated positively with lymphocyte and platelet counts. Significantly low level of α-tocopherol and high level of TBARS were observed in cirrhotic patients with hepatocellular carcinoma. From these results, it was suggested that arachidonic acid deficiency in mononuclear cells may have an important role in the progression of liver cirrhosis and that nutritional management preventing arachidonic acid deficiency may be useful in the treatment of liver cirrhosis.
2.The effects of vitamin E supplementation on the fatty acid composition of RBC and pathophysiology in HCV infected patients were investigated. The serum ALT activity was improved … More in 5 of 8 patients. The arachidonic acid and docosahexaenoic acid levels and polyunsaturated fatty acid/saturated fatty acid (P/S) ratio in RBC, which were significantly lower in the patients than controls, were elevated following vitamin E supplementation. The improvement in fatty acid composition was observed particularly in the patients who responded to the vitamin E therapy. A possibility of vitamin E therapy for the prevention of disease progression in HCV infected chronic liver diseases was suggested.
3.The effects of dietary polyunsaturated fatty acid and α-tocopherol intake on serum ALT activity were evaluated comparing the habitual food intake and plasma fatty acid composition in cirrhotic patients living in two different regions in Japan. Serum ALT activity correlated negatively with plasma arachidonic acid and α-tocopherol levels. Dietary intake of linoleic acid and the P/S ratio in dietary fat correlated positively with serum ALT. A significance of dietary intake of polyunsaturated fatty acid and anti oxidative vitamins was postulated. Less

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Ota Y.: "Vitamin E supplementation increases polyunsaturated fatty acids of RBC membrane in HCV infected patients"Nutrition. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okita M.: "Chronic hepatic disease and dietary instruction"Hepatology Res. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okita M: "Arachidonic acid in mononuclear cells and its clinical significance in HCV cirhotic patients"Nutrition. 19・9. 727-732 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mahmood S.: "Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C"Free Radic res. 37・7. 781-785 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 太田 泰子: "C型慢性肝炎・肝硬変例の赤血球膜脂肪酸組成から見たビタミンE投与の評価"栄養-評価と治療. 20・6. 595-598 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasagawa T.: "Influences of a dietary fatty acid composition on the emergence of glutathione S-transferase-P (GST-P) positive foci in the liver of carcinogen-treated rats"Prostagl Leukotr Essent Fatty Acids. 67・5. 327-332 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okita M.: "Habitual food intake and polyunsaturated fatty acid deficiency in liver cirrhosis"Nutrition. 18・4. 304-308 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 冨岡加代子: "肝癌合併及び非合併肝硬変における栄養状態の比較と栄養療法に関する考察"栄養-評価と治療. 18・4. 487-491 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okita M.: "Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats"Prostagl Leukotr Essent Fatty Acids. 64・4/5. 273-279 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okita M.: "Effect of a moderately energy-restricted diet on obese patients with fatty liver"Nutrition. 17・7/8. 542-547 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okita M.: "Dietary arachidonic acid and alcohol. In Nutrition and Alcohol, Watson RR and Preedy VR eds."CRC Press. 429 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Misako Okita, Takayo Sasagawa, Junko Yamamoto: "Dietary arachidonic acid and alcohol. In Nutrition and Alcohol-Linking nutrient interactions and dietary intake"(Watson Rrand Preedy VR eds.) CRC Press. 249-259 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misako Okita: "Chronic hepatic disease and dietary instruction"Hepatology Res. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuko Ota, Takayo sasagawa, Kazuhiko Suzuki, Kayoko Tomioka, Ayako Nagai, Gohichj Niiyama, Miwa Kawanaka, Gotado Yamada, Misako Okita: "Vitamin E supplementation increases polyunsaturated fatty acids of RBC membrane in HCV infected patients"Nutirion. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misako Okita, Kayoko Tomioka, Yasuko Ota, Takayo Sasagawa, Toshiya Osawa, Nobuyuki Sakai, Mitsuhiko Kawaguchi, Tatsuya Itoshima: "Arachidonic acid in mononuclear cells and its clinical significance in HCV cirrhotic patients"Nutrition. 19(9). 727-732 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 太田泰子, 笹川貴代, 冨岡加代子, 永井亜矢子, 鈴木和彦, 山田剛太郎, 沖田美佐子: "C型慢性肝炎・肝硬変例の赤血球膜脂肪酸組成からみたビタミンE投与の評価"栄養-評価と治療. 20(6). 595-598 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sabina Mahmood, Gotaro Yamada, Gouichi Niiyama, Miwa Kawanaka, Kazumi Togawa, Miho Sho, Toshio Ito, Takayo Sasagawa, Misako Okita, Hajime Nakamura, Junji Yodoi: "Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C"Free Radic Res. 37(7). 781-785 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takayo Sasagawa, Kaori Kosai, Yasuko Ota, Masaharu Mon, Misako Okita: "Influences of a dietary fatty acid composition on the emergence of glutathione S-transferase-P (GST-P) positive foci in the liver of carcinogen-treated rats"Prostagl Leukotr Essent Fatty Acids. 67(5). 327-332 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misako Okita, Takayo Sasagawa, Kayoko Tomioka, Kaori Hasuda, Yasuko Ota, Kazuhiko Suzuki, Akiharu Watanabe: "Habitual food intake and polyunsaturated fatty acid deficiency in liver cirrhosis"Nutrition. 18(4). 304-308 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 冨岡加代子, 笹川貴代, 太田泰子, 川田 順, 中山敏子, 川口光彦, 坂井宣行, 大澤俊哉, 糸島達也, 沖田美佐子: "肝癌合併及び非合併肝硬変における栄養状態の比較と栄養療法に関する考察"栄養-評価と治療. 18(4). 487-91 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misako Okita, Takayo Sasagawa, Yasuko Ota, Takao Kaneyuki, Kazuhiko Suzuki: "Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol-treated rats"Prostagl Leukotr Essent Fatty Acids. 64(4/5). 273-79 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Misako Okita, Mayumi Hayashi, Takayo Sasagawa, Koji Takagi, Kazuhiko Suzuki, Shingo Kinoyama, Toshio Ito, Gotaro Yamada: "Effect of a moderately energy0restricted diet on obese patients with fatty liver"Nutrition. 17(7/8). 542-547 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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