2002 Fiscal Year Final Research Report Summary
Signal transduction of GPI-anchored proteins in lipid rafts
| Project/Area Number |
13680701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
KASAHARA Kohji Tokyo Metropol Inst Med Sci, 東京都臨床医学総合研究所, 研究員 (60250213)
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| Project Period (FY) |
2001 – 2002
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| Keywords | glycosphingolipids / raft / GPI-anchor / signal transduction |
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| Research Abstract |
The mechanism of signal transduction by GPI-anchored neural cell adhesion molecules is obscure, because GPI-anchored proteins have no transmembrane domains. Recent studies suggest dynamic clustering of glycosphingolipids (lipid rafts) function as platforms for attachment of GPI-anchored proteins, src-family kinases during signal transduction. In this research project, I pursued clarifying mechanism of signal transduction by GPI-anchored neural cell adhesion molecules.
I previously reported that GPI-anchored neural cell adhesion molecule TAG-1 transduces signal via src-family kinase Lyn in lipid rafts of rat primary cerebellar cultures. In this year, I found that phosphacan, TAG-1 ligand, induces signal transduction in lipis rafts via src-family kinase Lyn and has repulsive effects on rat primary cerebellar cultures.
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Research Products
(7 results)
