• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2002 Fiscal Year Final Research Report Summary

ANALYSIS OF STRIATAL LOCAL CIRCUITS BY SIMULTANEOUS PATCH CLAMP RECORDINGS FROM TWO CELLS

Research Project

Project/Area Number 13680887
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTOKYO METOROPOLITAN INSTITUTE OF GERONTOLOGY

Principal Investigator

AOSAKI Toshihiko  TOKYO METROPOLITAN INSTITIUTE OF GERONTOLOGY, NEURAL CIRCUITS DYNAMICS RESEARCH GROUP, GROUP LEADER, 東京都老人総合研究所・神経回路動態研究グループ, グループリーダー (70221033)

Co-Investigator(Kenkyū-buntansha) SUZUKI Takeo  TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY, NEURAL CIRCUITS DYNAMICS RESEARCH GROUP, RESEARCHER, 福祉振興財団東京都老人総合研究所・神経回路動態研究グループ, 研究員 (50306940)
MIURA Masami  TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY, NEURAL CIRCUITS DYNAMICS RESEARCH GROUP, RESEARCHER, 福祉振興財団東京都老人総合研究所・神経回路動態研究グループ, 研究員 (40291091)
Project Period (FY) 2001 – 2002
KeywordsSTRIATUM / BASAL GANGLIA / FAST-SPIKING / PARVALUBMIN / INFORMATION PROCESSING / INTERNEURON / PARKINSON'S DISORDER / SLICE
Research Abstract

The basal ganglia is involved in adaptive control of action in the motor, planning and cognitive spheres (Graybiel, 1995). Corticostriatal relevant inputs, convergent or divergent, induce modular activation of neurons in patchy domains in the striatum, the input stage of the basal ganglia. These matrix domains called matrisomes consist of activated medium spiny (MS) projection neurons located in the larger modules determined by activated parvalbumin-positive g-aminobutyric acid (GABA)interneurons and NADPH diaphorase-positive GABA interneurons (Parthasarathy and Graybiel, 1997 ; Berretta, Parthasarathy and Graybiel, 1997). However, how cortical inputs are processed, integrated and output in the matrisomes still remains elusive. Using paired recordings in mouse corticostriatal slices, we found that the feed-forward inhibition of the MS cells by a network of parvalbumin interneurons predominates in the striatal local circuitry and that MS cells within a sphere of 〜150 μm in diameter are under the influence of a single parvalbumin interneuron. Moreover, the inhibition significantly improves the spike timing precision and the signal-to-noise ratio of the striatal outputs. Thus, parvalbumin cell networks in the striatum may take part in the emergence of functional cell assemblies that could influence the temporal order of striatal outputs.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 青崎敏彦: "ドパミンと大脳基底核の神経可塑性"医学のあゆみ. 202巻3号. 167-170 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 青崎敏彦, 三浦正巳, 鈴木健雄, 辛龍文: "線条体におけるシナプス可塑性研究の現状"脳の科学. 23巻12号. 1055-1059 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki, T., Miura, M., Nishimura, K., Aosaki, T.: "Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons"Journal of Neuroscience. 21. 6492-6501 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakajima, M., Miura, M., Aosaki, T. and Shirasawa, T.: "Deficiency of presenilin-1 incre* calcium-dependent vulnerability of neurons to oxidative stress in vitro"Journal of Neurochemisty. 78(4). 807-814 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T., Miura, M., Nishimura, K. and Aosaki, T.: "Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons"Journal of Neuroscience. 21. 6492-6501 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2004-04-14  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi