Study of Remote early diagnosis system for malfunction of implantable artificial heart

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 13680951
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Hokkaido Tokai University
• Principal Investigator: OKAMOTO Eiji Hokkaido Tokai University, Department of Information Science, Associate Professor, 工学部, 助教授 (30240633)
• Co-Investigator(Kenkyū-buntansha): YANBE Tomoyuki Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (70241578) ; YOSHIZAWA Makoto Tohoku University, Information Synergy Center, Professor, 情報シナジーセンター, 教授 (60166931) ; MITAMURA Yoshinori Hokkaido University, Graduate School of engineering, Professor, 大学院・工学研究科, 教授 (70002110)
• Project Period (FY): 2001 – 2003
• Keywords: Artificial Heart / Early Diagnosis / Assist pump / Adaptive Filter / Electro-stethoscope / Mobile Communications / Remote Monitoring / CAD

Research Abstract

We have studied early diagnosis system for detecting symptom of malfunction of an implanted artificial heart before threatening patients' life. The early diagnosis system consists of a electro-stethoscope and a mobile computer. Sound signal generated by an artificial heart is an index of the degree of mechanical deterioration, because the sound signal is related to the condition of each mechanical components of the artificial heart. Sound data, which are detected on the surface of the body of a discharged patient in whom a TAK has been implanted. are transmitted to a host computer in a hospital via a mobile telephone (PHS).
The early diagnosis system has two type of unique filters 1) an optimum frequency characteristics of low-pass filter based on simulating sound transmission characteristics of tissue, and 2) adaptive noise canceller, in order to eliminate ambient sound signal mixed in artificial heart's sound signal. The early diagnosis system was able to detect symptom of pump malfunction in in-vivo experiment using a goat implanted an undulation pump total artificial heart. The results of this study showed that the early diagnosis system contributes to improvement in the quality of life of discharged artificial heart patients by ensuring their safety.

Research Products

• [Publications] E Okamoto, E Iawasawa, S Suzuki, S Fukuoka, Y Mitamura: "Feasibility of a remote monitoring system for patients with a implantable left ventricular assist device using personal handy-phone system"Journal of Artificial Organs. 4. 172-179 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Eiji Okamoto, Kazuya Watanabe, Kunihiro Hashiba, Taku Inoue, Eichi Iwazawa, Masato Momoi, Takuya Hashimoto, Yoshino Mitamura: "Optimum selection of an implantable secondary battery for an artificial heart by examination of the cycle life test"ASAIO Journal 2002. 495-502 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Eiji Okamoto, Takuya Hashimoto, Taku Inoue, Yoshinori Mitamura: "Blood compatible design of a pulsatile blood pump using comptational fluid dynamics and computer-aided design and manufacturing technology"Artificial Organs. 27(1). 61-67 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] E.Okamoto, T.Inoue, K.Watanabe, T, Hashimoto, E.Iwazawa, Y.Abe, T.Chinzei, T.Isoyama, S.Kobayashi, I.Saito, F.Sato, H.Matsuki, K.Imachi, Y.Mitamura: "Development of an implantable high-energy and compact battery system for artificial heart"Artificial Organs. 27(2). 184-188 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Okamoto E., Inoue T., Hashimoto T., Saito I., Abe Y., Chinzei T., Isoyama T, Imachi K., Mitamura Y.: "Development of an Electro-stethoscope System and Design of an Optimum Filter Based on Tissue Sound Transmission for Noninvasive Early Diagnosis of Malfunction of an Implanted Mechanical Total Artificial Heart"Artificial Organs. 28(2). 226-237 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] E Okamoto, E Jawasawa, S Suzuki, S Fukuoka, Y Mitamura: "Feasibility of a remote monitoring system for patients with a implantable left ventricular assist device using personal handy-phone system"Journal of Artificial Organs. 4. 172-179 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Eiji Okamoto, Kazuya Watanabe, Kunihiro Hashiba, Taku Inoue, Eichi Iwazawa, Masato Momoi, Takuya Hashimoto, Yoshinori Mitamura: "Optimum selection of an implantable secondary battery for an artificial heart by examination of the cycle life test"ASAIO Journal. 2002. 495-502 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Eiji Okamoto, Takuya Hashimoto, Taku Inoue, Yoshinori Mitamura.: "Blood compatible design of a pulsatile blood pump using comptational fluid dynamics and computer-aided design and manufacturing technology"Artificial Organs. 27(1). 61-67 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] E.Okamoto, T.Inoue, K.atnnabe, E.Iwazawa, Y.Abe, T.Chinzei, T.Isoyama, S.Kobayashi, I.Saito, F.Sato, H.Matsuki, K.Imachi, Y.Mitamura.: "Development of an implantable high-energy and compact battery system for artificial heart"Artificial Organs. 27(2). 184-188 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Okamoto E., Inoue T., Hashimoto T., Saito I., Abe Y, Chinzei T., Isoyama T, Imachi K., Mitamura Y.: "Development of an Electro-stethoscope System and Design of an Optimum Filter Based on Tissue Sound Transmission for Noninvasive Early Diagnosis of Malfunction of an Implanted Mechanical Total Artificial Heart"Artificial Organs. 28(2). 226-237 (2004)
  • Description: 「研究成果報告書概要(欧文)」より