Functional analysis of costimulatory molecules in oral diseases and their intervention for clinical application

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 13854021
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: 病態科学系歯学(含放射線系歯学)
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: AZUMA Miyuki Tokyo Medical and Dental University, Graduate Sch Med and Dent Sciences, Professor, 大学院・医歯学総合研究科, 教授 (90255654)
• Co-Investigator(Kenkyū-buntansha): HASHIGUCHI Masaaki Tokyo Medical and Dental University, Graduate Sch Med and Dent Sciences, Assistant Professor, 大学院・医歯学総合研究科, 助手 (20372443)
• Project Period (FY): 2001 – 2005
• Keywords: Immunology / Dentistry / Infectious diseases / Cancer / Costimulatory molecules / Oral diseases / Dendritic cells / T lymphocytes

Research Abstract

We investigated expression and function of costimulatory molecules including PD-1:B7-H1/B7-DC, ICOS:B7h, BTLA, B7-H3, and B7-H3 in oral immune responses and diseases. B7-H1 that is one of ligands for PD-1 was induced on a various inflammatory tissue cells as well as immune cells, whereas expression of B7-DC was limited on activated dendritic cells (DCs) and macrophages. Our results demonstrate the involvement of PD-1:B7-H1 pathway in immune regulation based on the studies from the comparative analyses between expression and clinical features and prognosis in oral lichen planus (OLP) and oral cancer, and in addition, the in vivo treatments with blocking monoclonal antibodies in models of skin contact hypersensitivity and oral cancer. A ligand of ICOS, B7h was less expressed as compared with B7-H1, but was expressed at high levels on endothelial cells in OLP and oral cancer tissues, suggesting the involvement of B7h in lymphocyte infiltration into the tissues.
We have established a murine pulpitis model using fresh-frozen decalcified hard tissue sections and an immunofluorescence staining and examined dental pulp after dentin exposure. We found that two types of DCs, CD11c^+F4/80^- and CD11c^-F4/80^+, exist in dental pulp. CD11c^+F4/80^- cells located in the pulp-dentin border and expressed constitutively TLR2, TLR4, and CD205. CD11c^-F4/80^+ cells located in the central pulp and were lacking the above molecules. Both types of cells migrated rapidly to the P-D border of treated cusp side, but a part of F4/80^+ cells alone induced a costimulatory molecule CD86. Simultaneously, F4/80^+CD86^+ cells in the regional lymph nodes increased, suggesting the migration of these cells from the pulp. These results suggest that antigen-capture and migration of pulpal DCs may occur and the migrated DCs may induce a consequent adoptive immune response. Our findings provide important information for estimating the healing properties of dental pulp and for developing possible treatments of dental restoration.

Research Products

• [Journal Article] Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma. (2006)
  • Author(s): Tsushima F, Tanaka K, Otsuki N, Youngnak P, Iwai H, Omura K, Azuma M
  • Journal Title: Oral Oncol 42(3) Pages: 268-274
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues. (2006)
  • Author(s): Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Omura K, Azuma M
  • Journal Title: Scan. J. Immunol 63 Pages: 191-198
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential role of PD-L1 and PD-L2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. (2006)
  • Author(s): Zhu B, Guleria I, Khosroshahi A, Chitnis T, Imitalo J, Azuma M, Yagita H, Sayegh MH, Khoury SJ
  • Journal Title: J. Immunol 176 Pages: 3480-3489
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma. (2006)
  • Author(s): Tsushima F, Tanaka K, Otsuki N, Youngnak P, Iwai H, Omura K, Azuma M.
  • Journal Title: Oral Oncol. 42(3) Pages: 268-274
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues. (2006)
  • Author(s): Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Omura K, Azuma M.
  • Journal Title: Scan.J.Immunol. 63 Pages: 191-198
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential role of PD-L1 and PD-L2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. (2006)
  • Author(s): Zhu B, Guleria I, Khosroshahi A, Chitnis T, Imitalo J, Azuma M, Yagita H, Sayegh MH, Khoury SJ.
  • Journal Title: J.Immunol. 176 Pages: 3480-3489
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. (2005)
  • Author(s): Sandner SE, Clarkson MR, Salam AD, Sanchez-Fueyo A, Domenig C, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH
  • Journal Title: J. Immnuol 174 Pages: 3408-3415
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinical significance of PD-L1 and PD-L2 expression in human esophageal cancer. (2005)
  • Author(s): Ohigashi Y, Sho M, Yamada Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Tsurui Y, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y
  • Journal Title: Clin. Cancer Res 11(8) Pages: 2947-2953
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. (2005)
  • Author(s): Tsuda M, Matsumoto K, Inoue H, Matsumura M, Nakano T, Mori A, Azuma M, Nakanishi Y
  • Journal Title: Biochem Biophys Res Commun 330 Pages: 263-270
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Subcutaneous injection of a TNF-a antagonist peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. (2005)
  • Author(s): Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese B.J., Yoshimasu H, Baron R, Ohya K, Amagasa T
  • Journal Title: J. Med. Dent. Sci 52 Pages: 91-99
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. (2005)
  • Author(s): Ito T, Ueno T, Yuan X, Clarkson MR, Yagita H, Azuma M, Auchincloss Jr.H, Sayegh MH, Najafian N
  • Journal Title: J. Immunol 174 Pages: 6648-6656
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A critical role for the programmed death ligand l in fetomaternal tolerance. (2005)
  • Author(s): Guleria I, Khousroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, Noelle RJ, Coyle A, Mellor AL, Khoury SJ, Sayegh MH
  • Journal Title: J. Exp. Med 202 Pages: 231-237
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blockade of B7-H1 on macrophages suppresses CD4^+ T cell proliferation by augmenting IFN-γ-induced nitric oxide production. (2005)
  • Author(s): Yamazaki T, Akiba H, Koyanagi A, Azuma M, Yagita H, Okumura K
  • Journal Title: J. Immunol 175 Pages: 1586-1592
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 口腔扁桃胚中心における新規共刺激分子とそのレセプターの発現に関する組織学的、細胞学的解析 (2005)
  • Author(s): 杉田 玄, 鶴井博理, 藤森正登, 榎本冬樹, 池田勝久, 東 みゆき, 広瀬幸子
  • Journal Title: 日本耳鼻咽喉科学会会報 108(1) Pages: 31-37
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. (2005)
  • Author(s): Sandner SE, Clarkson MR, Salam AD, Sanchez-Fueyo A, Domenig C, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH.
  • Journal Title: J.Immnuol. 174 Pages: 3408-3415
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical significance of PD-L1 and PD-L2 expression in human esophageal cancer. (2005)
  • Author(s): Ohigashi Y, Sho H, Yamada Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Tsurui Y, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y.
  • Journal Title: Clin.Cancer Res. 11(8) Pages: 2947-2953
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. (2005)
  • Author(s): Tsuda M, Matsumoto K, Inoue H, Matsumura M, Nakano T, Mori A, Azuma M, Nakanishi Y.
  • Journal Title: Biochem Biophys Res Commun. 330 Pages: 263-270
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Subcutaneous injection of a TNF-a antagonist peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. (2005)
  • Author(s): Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese B.J., Yoshimasu H., Baron R, Ohya K, Amagasa T.
  • Journal Title: J.Med.Dent.Sci. 52 Pages: 91-99
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. (2005)
  • Author(s): Ito T, Ueno T, Yuan X, Clarkson MR, Yagita H, Azuma M, Auchincloss Jr.H, Sayegh MH, Najafian N.
  • Journal Title: J.Immunol. 174 Pages: 6648-6656
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A critical role for the programmed death ligand 1 in fetomaternal tolerance. (2005)
  • Author(s): Guleria I, Khousroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, Noelle RJ, Coyle A, Mellor AL, Khoury SJ, Sayegh MH.
  • Journal Title: J.Exp.Med. 202 Pages: 231-237
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of B7-H1 on macrophages suppresses CD4^+ T cell proliferation by augmenting IFN-γ-induced nitric oxide production. (2005)
  • Author(s): Yamazaki T, Akiba H, Koyanagi A, Azuma H, Yagita H, Okumura K.
  • Journal Title: J.Immunol. 175 Pages: 1586-1592
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immuno-histolofical and-cytological Examinations on Distribution Newly Reported Co-stimulatory Molecules in Germinal Center of Human Tonsils. (2005)
  • Author(s): Sugita G, Tsurui H, Fujimori M, Enomoto F, Ikeda K, Azuma M, Hirose S.
  • Journal Title: Nippon Jibiinkoka Gakkai Kaiho 108(1) Pages: 31-37
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] B7-DC regulates asthumatic responses by interferon-g-dependent mechanism. (2004)
  • Author(s): Matsumoto K, Inoue H, Nakano T, Tsuda M, Yoshiura Y, Fukuyama S, Tsushima F, Hoshino T, Aizawa H, Akiba h, Pardoll D, Yagita H, Azuma M, Hara N
  • Journal Title: J. Immunol 172 Pages: 2530-2541
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] BAFF/BlyS can potentiate B-cell selection with the B-cell co-receptor complex. (2004)
  • Author(s): Hase H, Kanno Y, Kojima M, Hasegawa K, Sakurai D, Kojima H, Ysuchiya N, Tokunaga K, Masawa N, Azuma M, Okumura K, Kobata T
  • Journal Title: Blood 103 Pages: 2257-2265
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] PD-1/PD-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. (2004)
  • Author(s): Aramaki O, Shirasugi N, Takayama T, Shimazu M, Kitajima M, Azuma M, Ikeda Y, Okumura K, Yagita H, Niimi M
  • Journal Title: Transplantation 77 Pages: 6-12
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The expression and function of costimulatory molecules B7h and B7-H1 on colonic epithelial cells. (2004)
  • Author(s): Nakazawa A, Dotan I, Brimnes J, Allez m, Shao L, Tsushima F, Azuma M, Mayer L
  • Journal Title: Gastroenterology 126 Pages: 1347-1357
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Costimulation via glucocorticoid-induced tumor necrosis factor receptor (GITR) in both conventional and CD25^+ regulatory CD4^+ T cells. (2004)
  • Author(s): Kanamaru F, Youngnak P, Takahashi T, Sakaguchi S, Ishikawa I, Azuma M
  • Journal Title: J. Immunol 172 Pages: 7306-7314
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4^+ T lymphocytes. (2004)
  • Author(s): Zhou X, Kubo M, Nishitsuji H, Kurihara K, Ikeda T, Ohashi T, Azuma M, Masuda T, Kannagi M
  • Journal Title: Virology 325 Pages: 252-263
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Accessory cell function of airway epithelial cells. (2004)
  • Author(s): Oei E, Kalb T, Beuria P, Allez M, Nakazawa A, Azuma M, Timony M, Stuart Z, Chen H, Sperber K.
  • Journal Title: Am. J. Physiol Cell Mol Physiol 287 Pages: L318-L331
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] B7-H1 expression in non-small cell lung cancer and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. (2004)
  • Author(s): Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M
  • Journal Title: Clin. Cancer Res. 10 Pages: 5094-5100
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of membrane-bound and soluble receptor activator of NF-kB ligand (RANKL) in human T cells. (2004)
  • Author(s): Kanamaru F, Iwai H, Ikeda T, Nakajima A, Ishikawa I, Azuma M
  • Journal Title: Immunol. Let 94(3) Pages: 239-246
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. (2004)
  • Author(s): Youngnak-piboonratanakit P, Tsusima F, Otsuki N, Igarashi H, Machida U, Iwai H, Takahashi Y, Okura K, Yokozeki H, Azuma M
  • Journal Title: Immunol. Let 94(3) Pages: 215-222
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. (2004)
  • Author(s): Kagahama K, Aoki K, Konaka K, Saito H, Varghese B.J, Azuma M, Ohya K, K.Ohyama
  • Journal Title: Bone 35 Pages: 1059-1068
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts. (2004)
  • Author(s): N, Suzuki J, Kosuge H, Haraguchi G, Onai Y, Futamatsu H, Maejima Y, Gotoh R, Saiki H, Tsushima F, Azuma M, Isobe M
  • Journal Title: Arterioscler Thromb Vasc Biol 24(11) Pages: 2057-2062
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] B7-DC regulates asthmatic responses by interferon-g-dependent mechanism. (2004)
  • Author(s): Matsumoto K, Inoue H, Nakano T, Tsuda M, Yoshiura Y, Fukuyama S, Tsushima F, Hoshino T, Aizawa H, Akiba H, Pardoll D, Yagita H, Azuma H, Hara N.
  • Journal Title: J.Immunol. 172 Pages: 2530-2541
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] BAFF/BlyS can potentiate B-cell selection with the B-cell co-receptor complex. (2004)
  • Author(s): Hase H, Kanno Y, Kojima M, Hasegawa K, Sakurai D, Kojima H, Ysuchiya N, Tokunaga K, Masawa N, Azuma M, Okumura K, Kobata T.
  • Journal Title: Blood. 103 Pages: 2257-2265
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PD-1/PD-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. (2004)
  • Author(s): Aramaki O, Shirasugi N, Takayama T, Shimazu M, Kitajima M, Azuma M, Ikeda Y, Okumura K, Yagita H, Niimi M.
  • Journal Title: Transplantation. 77 Pages: 6-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The expression and function of costimulatory molecules B7h and B7-H1 on colonic epithelial cells. (2004)
  • Author(s): Nakazawa A, Dotan I, Brimnes J, Allez M, Shao L, Tsushima F, Azuma M, Mayer L.
  • Journal Title: Gastroenterology. 126 Pages: 1347-1357
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Costimulation via glucocorticoid-induced tumor necrosis factor receptor (GITR) in both conventional and CD25^+ regulatory CD4^+ T cells. (2004)
  • Author(s): Kanamaru F, Youngnak P, Takahashi T, Sakaguchi S, Ishikawa I, Azuma H.
  • Journal Title: J.Immunol. 172 Pages: 7306-7314
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inducible-costimulator-mediated suppression of human immunodeficiency virus type I replication in CD4^+ T lymphocytes. (2004)
  • Author(s): Zhou X, Kubo M, Nishitsuji H, Kurihara K, Ikeda T, Ohashi T, Azuma M, Masuda T, Kannagi M.
  • Journal Title: Virology. 325 Pages: 252-263
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Accessory cell function of airway epithelial cells (2004)
  • Author(s): Oei E, Kalb T, Beuria P, Allez M, Nakazawa A, Azuma, M, Timony M, Stuart Z, Chen H, Sperber K.
  • Journal Title: Am.J.Physiol Cell Mol Physiol. 287 Pages: L318-L331
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] B7-H1 expression in non-small cell lung cancer and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. (2004)
  • Author(s): Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M.
  • Journal Title: Clin.Cancer Res. 10 Pages: 5094-5100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of membrane-bound and soluble receptor activator of NF-κB ligand (RANKL) in human T cells. (2004)
  • Author(s): Kanamaru F, Iwai H, Ikeda T, Nakajima A, Ishikawa I, Azuma M.
  • Journal Title: Immunol.Let. 94(3) Pages: 239-246
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. (2004)
  • Author(s): Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Machida U, Iwai H, Takahashi Y, Okura K, Yokozeki H, Azuma M.
  • Journal Title: Immunol.Let. 94(3) Pages: 215-222
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. (2004)
  • Author(s): Nagahama K, Aoki K, Nonaka K, Saito H, Varghese B.J, Azuma M, Ohya K, K.Ohyama.
  • Journal Title: Bone. 35 Pages: 1059-1068
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts. (2004)
  • Author(s): N, Suzuki J, Kosuge H, Haraguchi G, Onai Y, Futamatsu H, Maejima Y, Gotoh R, Saiki H, Tsushima F, Azuma M, Isobe M.
  • Journal Title: Arterioscler Thromb Vase Biol. 24(11) Pages: 2057-2062
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ameliorating effect of anti-Inducible Co-stimulator monoclonal antibody in a murine model of chronic colitis. (2003)
  • Author(s): Totsuka T, Knai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M
  • Journal Title: Gastroenterology 124 Pages: 410-421
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in Nonobese Diabetic (NOD) mice. (2003)
  • Author(s): Ansari M J, Salama A D, Smith R N, Yagita H, Azuma M, Iwai H, Khoury S J, Auchincloss Jr H, Sayegh M H
  • Journal Title: J. Exp. Med 198 Pages: 63-69
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cooperative B7-1/2 (CD80/CD86) and B7-Dc (PD-L2) costimulation of CD4 T cells independent of the PD-1 receptor. (2003)
  • Author(s): Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F
  • Journal Title: J. Exp. Med 198 Pages: 31-38
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. (2003)
  • Author(s): Salama AD, Chitnis T, Imitola J, Yagita H, Azuma M, Tushima F, Sayegh MH, Khoury S J
  • Journal Title: J. Exp. Med 198 Pages: 71-78
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential binding properties of B7-H1 and B7-DC to programmed death-1 (PD-1). (2003)
  • Author(s): Pornpan Y, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M
  • Journal Title: Biochem. Biophys. Res. Commun 307 Pages: 672-677
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. (2003)
  • Author(s): Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumnura K, Azuma M
  • Journal Title: Eur. J. Immunol 33 Pages: 2773-2782
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. (2003)
  • Author(s): Iwai H, Abe S, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M
  • Journal Title: J. Immunol 171 Pages: 2848-2854
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. (2003)
  • Author(s): Kanai T, Totsuka T, Uraushihara K, Makita S, Iiyama R, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M
  • Journal Title: J. Immunol 171 Pages: 4156-4163
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ameliorating effect of anti-Inducible Co-stimulator monoclonal antibody in a murine model of chronic colitis. (2003)
  • Author(s): Totsuka T, Knai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M.
  • Journal Title: Gastroenterology. 124 Pages: 410-421
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in Nonobese Diabetic (NOD) mice. (2003)
  • Author(s): Ansari M J, Salama A D, Smith R N, Yagita H, Azuma M, Iwai H, Khoury S J, Auchincloss Jr H, Sayegh M H.
  • Journal Title: J.Exp.Med. 198 Pages: 63-69
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cooperative B7-1/2 (CD80/CD86) and B7-Dc (PD-L2) costimulation of CD4 T cells independent of the PD-1 receptor. (2003)
  • Author(s): Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F.
  • Journal Title: J.Exp.Med. 198 Pages: 31-38
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. (2003)
  • Author(s): Salama AD, Chitnis T, Imitola J, Yagita H, Azuma M, Tushima F, Sayegh MH, Khoury SJ.
  • Journal Title: J.Exp.Med. 198 Pages: 71-78
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential binding properties of B7-H1 and B7-DC to programmed death-1 (PD-1). (2003)
  • Author(s): Pornpan Y, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M.
  • Journal Title: Biochem.Biophys.Res.Commun. 307 Pages: 672-677
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. (2003)
  • Author(s): Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M.
  • Journal Title: Eur.J.Immunol. 33 Pages: 2773-2782
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. (2003)
  • Author(s): Iwai H, Abe S, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma H.
  • Journal Title: J.Immunol. 171 Pages: 2848-2854
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. (2003)
  • Author(s): Kanai T, Totsuka T, Uraushihara K, Makita S, Iiyama R, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma H, Chen L, Watanabe M.
  • Journal Title: J.Immunol. 171 Pages: 4156-4163
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (2002)
  • Author(s): Seko Y, Ishiyama S, Nishikawa T, Kasajima T, Hiroe M, Suzuki S, Ishikawa S, Kawai S, Tanaka Y, Azuma M, Kobata T, Yagita H, Okumura K, Nagai R
  • Journal Title: Cardiovasc Pathol 11 Pages: 166-170
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The effect of recombinant CD80-Adenovirus and interleukin-12 on generation of cytotoxic T lymphocytes against autologous tumour in patients with oral squamous cell carcinoma. (2002)
  • Author(s): Mogi S, Ebata T, Toda H, Hirano Y, Enomoto S, Azuma M
  • Journal Title: Asian J Oral Maxillofac Surg 14 Pages: 87-94
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential graft-versus-leukemia effect by CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis. (2002)
  • Author(s): Ohata J, Sakurai J, Saito K, Tani K, Asano S, Azuma M
  • Journal Title: Clin Exp Immunol 129 Pages: 61-68
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Amelioration of collagen-induced arthritis by blockade of ICOS-B7h costimulation. (2002)
  • Author(s): Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M
  • Journal Title: J Immunol 169 Pages: 4332-4339
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of PD-1 ligands by murine T cells and antigen-presenting cells. (2002)
  • Author(s): Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, Shin T, Tsuchiya H, Pardoll D M, Okumura K, Azuma M, Yagita H
  • Journal Title: J Immunol 169 Pages: 5538-5545
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (2002)
  • Author(s): Seko Y, Ishiyama S, Nishikawa T, Kasajima T, Hiroe M, Suzuki S, Ishikawa S, Kawai S, Tanaka Y, Azuma M, Kobata T, Yagita H, Okumura K, Nagai R.
  • Journal Title: Cardiovasc Pathol. 11 Pages: 166-170
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The effect of recombinant CD80-Adenovirus and interleukin-12 on generation of cytotoxic T lymphocytes against autologous tumour in patients with oral squamous cell carcinoma. (2002)
  • Author(s): Mogi S, Ebata T, Toda H, Hirano Y, Enomoto S, Azuma M.
  • Journal Title: Asian J Oral Maxillofac Surg. 14 Pages: 87-94
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential graft-versus-leukemia effect by CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis. (2002)
  • Author(s): Ohata J, Sakurai J, Saito K, Tani K, Asano S, Azuma M.
  • Journal Title: Clin Exp Immunol. 129 Pages: 61-68
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amelioration of collagen-induced arthritis by blockade of ICOS-B7h costimulation. (2002)
  • Author(s): Iwai H., Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M.
  • Journal Title: J Immunol. 169 Pages: 4332-4339
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of PD-1 ligands by murine T cells and antigen-presenting cells. (2002)
  • Author(s): Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, Shin T, Tsuchiya H, Pardoll D M, Okumura K, Azuma M, Yagita H.
  • Journal Title: J Immunol. 169 Pages: 5538-5545
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of CTLA-4 in murine contact hypersensivity. (2001)
  • Author(s): Nuriya S, Enomoto S, Azuma M
  • Journal Title: J Invest Dermatol 116 Pages: 764-768
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Rapid induction of CD95 ligand and CD4^+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation. (2001)
  • Author(s): Ebata T, Mogi S, Hata Y, Fujimoto J, Okumura K, Azuma M
  • Journal Title: Eur J Immunol 31 Pages: 1410-1416
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preferential blockade of CD8^+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute chronic graft-vs-host diseases. (2001)
  • Author(s): Nozawa K, Ohata J, Sakurai J, Hashimoto H, Yagita H, Okumura K, Azuma M
  • Journal Title: J Immunol 167 Pages: 4981-4986
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice. (2001)
  • Author(s): Okano M, Azuma M, Yoshino T, Hattori H, Nakada M, Satoskar A, Harn D A, Nakayama E, Akagi T, Nishizaki K
  • Journal Title: Am J Respir Crit Care Med 64 Pages: 1501-1507
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-IBBL in murine hearts with acute myocarditis caused by Coxsackievirus B3. (2001)
  • Author(s): Seko Y, Takahashi N, Oshima H, Shimozato O, Akiba H, Takeda K, Kobata T, Yagita H, Okumura K, Azuma M, Nagai R
  • Journal Title: J Pathol 195 Pages: 593-603
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of CTLA-4 in murine contact hypersensivity. (2001)
  • Author(s): Nuriya S, Enomoto S, Azuma M.
  • Journal Title: Invest Dermatol. 116 Pages: 764-768
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137(4-1BB) costimulation. (2001)
  • Author(s): Ebata T, Mogi S, Hata Y, Fujimoto J, Okumura K, Azuma M.
  • Journal Title: Eur J Immunol. 31 Pages: 1410-1416
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Preferential blockade of CD8+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute chronic graft-vs-host diseases. (2001)
  • Author(s): Nozawa K, Ohata J, Sakurai J, Hashimoto H, Yagita H, Okumura K, Azuma M.
  • Journal Title: J Immunol. 167 Pages: 4981-4986
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice. (2001)
  • Author(s): Okano M, Azuma M, Yoshino T, Hattori H, Nakada M, Satoskar A, Harn D A, Nakayama E, Akagi T, Nishizaki K.
  • Journal Title: Am J Respir Crit Care Med. 64 Pages: 1501-1507
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3. (2001)
  • Author(s): Seko Y, Takahashi N, Oshima H, Shimozato O, Akiba H, Takeda K, Kobata T, Yagita H, Okumura K, Azuma M, Nagai R.
  • Journal Title: J Pathol. 195 Pages: 593-603
  • Description: 「研究成果報告書概要(欧文)」より