2001 Fiscal Year Annual Research Report

胃癌の増殖と担癌患者の食思不振におけるレプチンとレプチン受容体の役割の研究

Research Project

Project/Area Number	13877082
Research Category	Grant-in-Aid for Exploratory Research
Research Institution	Shimane Medical University
Principal Investigator	木下芳一島根医科大学, 医学部, 教授 (30243306)
Keywords	レプチン / 胃癌 / 食欲
Research Abstract	進行胃癌例の食欲不振の原因として胃癌が産生し、血中に存在するレプチンが重要な役割を有しているか否かを明らかとするための検討を行っている。対象には進行胃癌患者を用い、血清中のレプチンをELISAにて、胃癌組織中のレプチンmRNAをreal time quantitative PCRによって測定し、visual analogue scaleを用いた胃癌患者の食欲の障害の程度の評価を行った。健常者に比較して進行胃癌例の血清中レプチンは高い傾向が認められたが、検討症例数がまだ少ないためか有意な差にはいたらなかった。胃癌組織からtotal RNAを抽出し、real time quantitative PCRを用いレプチンmRNAを測定すると、種々の量のレプチンmRNAが胃癌組織中で産生されていることが明らかとなった。次いで胃癌の進展度、組織型、Helicobacter pylori感染の有無と胃癌組織中mRNA量、血清レプチンレベルに関係があるか否かの検討を行ったが明らかな関係は認められなかった。また胃癌組織中レプチンmRNA量と血清レプチン、食欲障害の程度に関しても現在検討終了した症例数では明らかな相関関係は認められなかった。そこで来年度検討症例数を増加して検討を行うとともに、レプチンのObRbを介した胃癌細胞増殖に及ぼす効果について検討をすすめる予定である。

Research Products
(14 results)

All Other

All Publications (14 results)

[Publications] Kawamura A, et al.: "Correlation between microsatellite instability and matachronous disease"Cencer. 91. 339-345 (2001)
[Publications] Kazumori H, et al.: "Analysis of gastrin receptor gene expression in laser capture"FEBS LETTERS. 189. 208-214 (2001)
[Publications] Rumi MAK, et al.: "Peroxisome proliferator-activated receptor γ ligand induced"British J Cancer. 84. 1640-1647 (2001)
[Publications] Ishihara S, et al.: "Intragastric distribution of Helicobacter pylori during short-term omeprazole"Alimentary Pharmacology and Therapeutics. 15. 1485-1491 (2001)
[Publications] Fukuda R, et al.: "Clinical relevance of precore and basal core promoter variants of"J Pediatr Gastroenterol Nutr. 33. 301-306 (2001)
[Publications] Moriyama N, et al.: "E-Cadherin is essential for gastric epithelial restitution in vitro"J Lab Clin Med. 138. 236-242 (2001)
[Publications] Adachi K, et al.: "Influence of Helicobacter pylori infection and cetraxate on gastric mucosal"J Gastroenterol Hepatol. 16. 1211-1216 (2001)
[Publications] Fujishiro H, et al.: "The influence of Helicobacter pylori infection on the prevalence of"J.Gastroenterol Hepatol.. 16. 1217-1221 (2001)
[Publications] Ishihara S, et al.: "T cell-mediated cytotoxicity via Fas/^1Fas ligand signaling"Helicobacter. (in press).
[Publications] Takashima T, et al.: "Cardiovascular risk factors in subjects with Helicobacter pylori infection"Helicobacter. (in press).
[Publications] Kawashima K, et al.: "Locolization of calcitonin gene-related peptide receptors in rat gastric mucosa"Peptides. (in press).
[Publications] Kaji T, et al.: "Adherence of Helicobacter pylori to gastric epithelial cells and"J.Jab.Clin.Med. (in press).
[Publications] Kazumori H, et al.: "Time course changes of ECL cell markers in acutic acid-induced"Aimentary Pharmacology and Therapeutics. (in press).
[Publications] Kazumori H, et al.: "Localization of Reg receptor in fundic mucosa"J.Lad.Clin.Med. (in press).

2001 Fiscal Year Annual Research Report

胃癌の増殖と担癌患者の食思不振におけるレプチンとレプチン受容体の役割の研究

Principal Investigator

木下 芳一 島根医科大学, 医学部, 教授 (30243306)

Research Products

[Publications] Kawamura A, et al.: "Correlation between microsatellite instability and matachronous disease"Cencer. 91. 339-345 (2001)

[Publications] Kazumori H, et al.: "Analysis of gastrin receptor gene expression in laser capture"FEBS LETTERS. 189. 208-214 (2001)

[Publications] Rumi MAK, et al.: "Peroxisome proliferator-activated receptor γ ligand induced"British J Cancer. 84. 1640-1647 (2001)

[Publications] Ishihara S, et al.: "Intragastric distribution of Helicobacter pylori during short-term omeprazole"Alimentary Pharmacology and Therapeutics. 15. 1485-1491 (2001)

[Publications] Fukuda R, et al.: "Clinical relevance of precore and basal core promoter variants of"J Pediatr Gastroenterol Nutr. 33. 301-306 (2001)

[Publications] Moriyama N, et al.: "E-Cadherin is essential for gastric epithelial restitution in vitro"J Lab Clin Med. 138. 236-242 (2001)

[Publications] Adachi K, et al.: "Influence of Helicobacter pylori infection and cetraxate on gastric mucosal"J Gastroenterol Hepatol. 16. 1211-1216 (2001)

[Publications] Fujishiro H, et al.: "The influence of Helicobacter pylori infection on the prevalence of"J.Gastroenterol Hepatol.. 16. 1217-1221 (2001)

[Publications] Ishihara S, et al.: "T cell-mediated cytotoxicity via Fas/^1Fas ligand signaling"Helicobacter. (in press).

[Publications] Takashima T, et al.: "Cardiovascular risk factors in subjects with Helicobacter pylori infection"Helicobacter. (in press).

[Publications] Kawashima K, et al.: "Locolization of calcitonin gene-related peptide receptors in rat gastric mucosa"Peptides. (in press).

[Publications] Kaji T, et al.: "Adherence of Helicobacter pylori to gastric epithelial cells and"J.Jab.Clin.Med. (in press).

[Publications] Kazumori H, et al.: "Time course changes of ECL cell markers in acutic acid-induced"Aimentary Pharmacology and Therapeutics. (in press).

[Publications] Kazumori H, et al.: "Localization of Reg receptor in fundic mucosa"J.Lad.Clin.Med. (in press).

木下芳一島根医科大学, 医学部, 教授 (30243306)