遺伝子と栄養の相互作用における樹状突起形成のメカニズム解明

2015 Fiscal Year Annual Research Report

• Project/Area Number: 13F03798
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Moore Adrian 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30442932)
• Co-Investigator(Kenkyū-buntansha): MACCHI MARC 国立研究開発法人理化学研究所, 脳科学総合研究センター, 外国人特別研究員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: dendrite branching / nutrition

Outline of Annual Research Achievements

The dendrite arbor is patterned by growing in 2 dimensions (2D) cross the inner surface of the body wall epithelium and in 3D by detaching from the basal lamina of the body wall and invading into the epidermal cell layer. We’ve found that changing nutritional state by raising Drosophila larvae on food containing different amino-acid levels leads to dendritic shape changes and in particular modulating dendrite invasion into underlying epithelial cells. We discovered that Dystrophin promotes the 3D invasions of the epithelial cells by dendrites in a nutrition-dependent manner. In parallel, we monitored endogenous Dystrophin expression and found that Dystrophin was expressed in both sensory neurons and the underlying epidermal cells of the body wall.In summary, our data suggest that a genetic locus disrupted in Autism Spectrum Disorders controls dendrite patterning in response to nutritional state.

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。