Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 13GS0015
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Keio University
• Principal Investigator: ISHIKAWA Hiromichi Keio University, School of Medicine, Professor (20051667)
• Co-Investigator(Kenkyū-buntansha): SUEMATSU Makoto Keio University, School of Medicine, Professor (00206385) ; KOYASU Shigeo Keio University, School of Medicine, Professor (90153684) ; OHTEKI Toshiaki Akita University, School of Medicine, Professor (50233200) ; WATANABE Mamoru Tokyo Medical and Dental University, Graduate School, Department of Gastroenterology and Hepatology, Professor (10175127) ; HACHIMURA Satoshi University of Tokyo, Graduate School of Agricultural and Life Sciences, Department of Applied Biological Chemistry, Associate Professor (40238019)
• Project Period (FY): 2001 – 2005
• Keywords: dietary substances / immunology / intestinal flora / γδ T cells / intestinal T cells / secretory IgA antibody / cryptopatch / isolated lymphoid follicles

Research Abstract

We started the above research project in 2001, and since 2001, distinctive features of functional crosstalk between intestinal flora, intestinal epithelial cells (IEC) and local as well as entire immune responses have been accumulated. Now, it is evident that intestinal flora and dietary substances that determine the composition of intestinal flora are important to the establishment of distinctive feature of intestinal immune response. Furthermore, it is speculated that the alteration of intestinal flora by modern dietary substances are involved in the pathogenesis of ulcerative colitis and Crohn's disease.
With regard to the summary of the research project, it should be pointed out that we clarified several distinctive aspects of intestinal immune response. First, acute graft-versus-host disease (aGVHD) is initiated by immunologically competent cytotoxic T cells (CTL) that express anti-host specificities. We have corroborated for the first time that gut Peyer's patches (PP) are required to activate anti-host CTL response in a well characterized murine aGVHD model. Second, we have verified that all lymph nodes including mesenteric lymph nodes, PP and isolated lymphoid follicles are not an absolute requirement for the histogenesis of recently discovered gut cryptopatches (CP) and development of γδ-IEL in the athymic nu/nu mice. These results indicate that gut CP might be the anatomical sites to generate progenitor γδ-IEL under this extreme lymphoid depletion. Third, it has been demonstrated that interleukin 15-dependent crosstalk between conventional and plasmacytoid dendrite cells is essential for CpG-induced immune activation. Taking all of these new findings together, we have accumulated new important evidence that is essential for the investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends.

Research Products

• [Journal Article] Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation (2006)
  • Author(s): Kuwajima, S
  • Journal Title: Nature Immunology 7 Pages: 740-746
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interleukin 15-dependent crosstalk betweei conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. (2006)
  • Author(s): Kuwajima, S., Sato, T., Ishida, K., Tada, H., Tezuka, H. Ohteki, T.
  • Journal Title: Nature immunology 7 Pages: 740-746
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Orally Tolerized T Cells Can Form Conjugates with APCs but Are Defective in Immunological Synapse Formation (2005)
  • Author(s): Ise, W
  • Journal Title: The Journal of Immunology 175 Pages: 829-838
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Intestinal γδ T Cells Develop in Mice Lacking Thymus,All Lymph Nodes,Peyer's Patches,and Isolated Lymphoid Follicles (2005)
  • Author(s): Nonaka, S
  • Journal Title: The Journal of Immunology 174 Pages: 1906-1912
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Colitis in Mice Lacking the Common Cytokine Receptor γ Chain Is Mediated by IL-6-Producing CD4+T Cells (2005)
  • Author(s): Kai, Y
  • Journal Title: Gastroenterology 128 Pages: 922-934
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of novel gut-associated lymphoid tissues in rat small intestine (2005)
  • Author(s): Hitotsumatsu, O
  • Journal Title: Journal of Gastroenterology 407 Pages: 956-963
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Orally Tolerized T Cells Can Form Conjugates with APCs but Are Defective in Immunological Synapse Formation. (2005)
  • Author(s): Ise, W., Nakamura, K., Shimizu, N., Goto, H., Fujimoto, K., Kaminogawa, S. liachimura, S.
  • Journal Title: l'he Journal of Immunology 175 Pages: 829-838
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intestinal γσ T Cells Develop in Mice Lacking Thymus, All Lymph Nodes, Peyers Patches, and Isolated Lymphoid Follicles. (2005)
  • Author(s): Nonaka, S., Naito, T., Chen. H., Yarnamoto, M. Moro, K., Kiyono, H., Hamada, H. Ishikawa, H.
  • Journal Title: The Journal of Immunology 174 Pages: 1906-1912
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development and Function of Organized Gut-Associated Lymphoid Tissues. (2005)
  • Author(s): Ishikawa, H, Kanamori, Y., Hamada, H. Kiyono, H.
  • Journal Title: In Mucosal Immunology. L. Mayer, J. Mestecky, M. E. Lamm, W. Strober, 1. Bienenstock, and J. R. Mcghee, eds. Academic Press, San Diego Pages: 385-405
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Colitis in Mice Lacking the Common Cytokine Receptor Chain Is Mediated by IL-6-Producing CD4 T Cells. (2005)
  • Author(s): Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushirna, T., Matsuda, C., Kishi, D., 1-larnada, H, Tamagawa, H, Ito, T., Yoshizald, K., Kishimoto, T., Matsuda, H. Kiyono
  • Journal Title: Gastroenterology 128 Pages: 922-934
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of novel gut-associated lymphoid tissues in rat small intestine. (2005)
  • Author(s): Takamiya, R., Muralcami, M., Ka, umura, M., Coda, N., Makino, N., Takamiya, Y., Yamaguchi, T., Ishimura, Y., Hozumi, N., M.
  • Journal Title: Journal of Gastroenterology 40 Pages: 956-963
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells (2004)
  • Author(s): Son, D.O
  • Journal Title: BioFactors 21 Pages: 395-398
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of the human taurine transporter by TNF-α and and an anti-inflammatory function of taurine in human intestinal Caco-2cells (2004)
  • Author(s): Mochizuki, T
  • Journal Title: BioFactors 21 Pages: 141-144
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of the method for evaluating prptective effect of food factors on THP-1-induced damage to human intestinal Caco-2 monolayers (2004)
  • Author(s): Watanabe, F
  • Journal Title: BioFactors 21 Pages: 145-147
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Activation of Ca^<2+>/calmodulin-dependent protein kinase ll is involved in hyperosmotic induction of the human taurine transporter (2004)
  • Author(s): Satsu, H
  • Journal Title: FEBS Letters 569 Pages: 123-128
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of candidate genes involved in somatosensory functions of cranial sensory ganglia (2004)
  • Author(s): Matsumoto, I
  • Journal Title: Molecular Brain Research 126 Pages: 98-102
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD4^-c-kit^-CD3ε^-IL-2Rα^+ Peyer's patch cells are a novel cell subset which secrete IL-5 in response to IL-2:implications for their role in IgA production (2004)
  • Author(s): Kuraoka, M
  • Journal Title: European Journal of Immunology 34 Pages: 1920-1929
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Kupffer Cells Alter Organic Anion Transport Through Multidrug Resistance Protein 2 in the Post-Cold Ischemic Rat Liver (2004)
  • Author(s): Kudo, A
  • Journal Title: HPPATOLOGY 39 Pages: 1099-1109
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular and clinical basis for the regeneration of human gastrointestinal epithelia (2004)
  • Author(s): Okamoto, R
  • Journal Title: Journal of Gastroenterology 39 Pages: 1-6
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interferon regulatory factor 1(IRF-1)and IRF-2 distinctively uP-regulate gene expression and production of Interleukin-7 in human intestinal epithelial cells (2004)
  • Author(s): Oshima, S
  • Journal Title: Molecular and Cellular Biology 24 Pages: 6298-6310
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cel1s by α-humulene (2004)
  • Author(s): Satsu, H
  • Journal Title: BioFactors 21 Pages: 137-139
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Gene expression profiling of cranial sensory ganglia that transmit food intake stimuli (2004)
  • Author(s): Matsumoto, I
  • Journal Title: BioFactors 21 Pages: 15-18
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cene expression profiling of cranial sensory ganglii that transmit food intake stimuli. (2004)
  • Author(s): Matsumoto, I., Nalcamura, S., Emori, Y., Aral, S. Abe, K.
  • Journal Title: BioFactors 21 Pages: 15-18
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Kupifer Cells Alter Organic Anion Transporte Through Multidrug Resistance Protein 2 in the Post- Cold Ischemic Rat Liver. (2004)
  • Author(s): Kudo. A., Kashiwagi, S., Kajhnura, M., Yoshimura, Y., Uchida, K., Arii, S. Sueinatsu, M.
  • Journal Title: IEPATOLOCY 39 Pages: 1099-1109
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. (2004)
  • Author(s): Okamoto, R. Watanabe, M.
  • Journal Title: Journal of Castroenterology 39 Pages: 1-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interferon Regulatory Factor I(IRE-I) and IRF-2 Distinctively Up-Regulate Cene Expression and Production of Interleukin-7 in Human Intestina Epithclial Cells. (2004)
  • Author(s): Oshima, S., Nakainura, T., Namild, S., Okada, E., Tsuchiya, K., Okamoto, R., Yamazaki, M., Yokota, T., Aida. M., Yamaguchi, Y., Kanal, T., Handa, H. Watanabe, M.
  • Journal Title: Molecular and cellular Biology 24 Pages: 6298-6310
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of interleukin-8 secretion in human intestinal epithdllal Caco^<-2> cells by α-humulenc. (2004)
  • Author(s): Satsu, H., Matsuda, T., Toshimitsu, T., Mori, A., Mae, T., Tsukagawa. M., Kitaliara, M. Shimizu, M.
  • Journal Title: BioFactors 21 Pages: 137-139
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco^<-2> cells. (2004)
  • Author(s): Son, D. 0., Satsu, H., Kiso, Y. Shimizu, M.
  • Journal Title: BioFactors 21 Pages: 395-398
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of the human taurmne transporter by TNF-cx and an anti-inflammatory function of taurinc in human intestinal Caco^<-2> cells. (2004)
  • Author(s): Mochizuki, T., Satsu, H., Nakano, T. Shimizu, M.
  • Journal Title: BioFactors 21 Pages: 141-144
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of the method for evaluating protective effect of food factors on THP-1-induced damage to human intestinal Caco^<-2> monolayers. (2004)
  • Author(s): Watanabe, F., Satsu, H., Mochizuki, T., Nakano, T. Shimizu, M.
  • Journal Title: BioFactors 21 Pages: 145-147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activation of Ca^<2+>/caImodulin-dependent protein Idnase II is involved in hyperosmotic induction of the human taurine transporter. (2004)
  • Author(s): Satsu, H., Manabe, M. Shimizu, M.
  • Journal Title: FEBS Letters 569 Pages: 123-128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of candidate genes involved in somatosensory functions of cranial sensory ganglia. (2004)
  • Author(s): Matsumoto, I., Nagamatsu, N., Aral, S., Emori, Y. Abe, K.
  • Journal Title: Molecular Brain Research 126 Pages: 98-102
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD4-c-kit-CD3ε-IL-2Ra^+ Peyer's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production. (2004)
  • Author(s): Kuraoka, M., Hashiguchi, M., Hachimura, S. Kaminogawa, S.
  • Journal Title: European Journal of Immunology 34 Pages: 1920-1929
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina (2003)
  • Author(s): Kajimura, M
  • Journal Title: The FASFB Journal 17 Pages: 506-508
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction (2003)
  • Author(s): Suzuki, H
  • Journal Title: Nature Immunology 4 Pages: 280-286
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The Role of Cryptopatch-Derived Intraepitheliall Lymphocytes in the Development of Chronic Ileocecitis (2003)
  • Author(s): Makita, S
  • Journal Title: Scandinavian Journal of Immunology 58 Pages: 428-435
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] New model for studying the migration of immune cells into intestinal epithelial cel1 mono]ayers (2003)
  • Author(s): Mori, A
  • Journal Title: Cytotechnology 43 Pages: 57-64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DNA Microarray Cluster Analysis Reveals Tissue Similarity and Potential Neuron-Specific Genes Expressed in Cranial Sensory Ganglia (2003)
  • Author(s): Matsumoto, I
  • Journal Title: Journal of Neuroscience Research 74 Pages: 818-828
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Proteome Analysis Reveals Caspase Activation in Hyporesponsive CD4T Lymphocytes Induced in Vivo by the Oral Administration of Antigen (2003)
  • Author(s): Kaji, T
  • Journal Title: The Journal of Biological Chemistry 278 Pages: 27836-27843
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Proteome database of unsensitized CD4 positive Tlymphocytes in T cell receptor transgenic mice (2003)
  • Author(s): Kaji, T
  • Journal Title: Electrophoresis 24 Pages: 3433-3444
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD11b+Peyer's Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells (2003)
  • Author(s): Sato, A
  • Journal Title: The Journal of Immunology 171 Pages: 3684-3690
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Petyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction (2003)
  • Author(s): Murai, M
  • Journal Title: Nature Immunology 4 Pages: 154-160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Carbon Monoxide Stimulates mrp2-Dependent Excretion of Bilirubin-IXa into Bile in the Perfused Rat Liver (2003)
  • Author(s): Norimizu, S
  • Journal Title: Antioxidants & Redox Signaling 5 Pages: 449-456
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mucosal T Cells Expressing High Levels of IL-7 Receptor are Potential Targets for Treatment of Chronic Colitis (2003)
  • Author(s): Yamazaki, M
  • Journal Title: The Journal of Immunology 171 Pages: 1556-1563
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina. (2003)
  • Author(s): Kajimura, M., Shimoyanm, M., Tsuyama, S., Suzuki, T., Kozakj, S., Takenalca, S., Tsubota, K., Oguchi, Y. Suematsu, M.
  • Journal Title: The FASEB Journal 17 Pages: 506-508
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Peyer's patch is the essential site in initiating inurine acute and lethal graft-versus-host reaction. (2003)
  • Author(s): Mural, M., Yoneyama, H., Ezald, T., Suematsu, M., Terashima, Y., Harada, A., Hamada, H., Asakura, H., Ishilcawa, H. Matsushima, K.
  • Journal Title: Nature Immunology 4 Pages: 154-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Carbon Monoxide Stimulates mrp2-Dependent Excretion of Billrubin-IXαinto Bile in the Perfused Rat Liver. (2003)
  • Author(s): Norimizu, S., Kudo, A., Kajimura, M., Ishikawa, Tanial, H., Yamaguchl, T., Fujii, K., Arii, S., Nimura, Y. Suematsu, M
  • Journal Title: Antioiodants & Redox Signaling 5 Pages: 449-456
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mucosal T Cells Expressing I Ugh Levels of IL-7 Receptor are Potential Targets for Treatment of Chronic Colitis. (2003)
  • Author(s): Yasnazalci, M., Yajima, T., Tanahe, M., Fukui, K., Okada, E., Okamoto, R., Oshima, S., Nalcamura, T., Kanal, T., Uehira, M., Takeuchi, T., Ishikawa, H., Ilibi, T. Watanabe, M.
  • Journal Title: The Journal of limnunology 171 Pages: 1556-1563
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] New model for studying the migration of immune cells into intestinal epithellal cell monolayers. (2003)
  • Author(s): Mori, A., Satsu, H. and Shimizu, M.
  • Journal Title: Cytotechnology 43 Pages: 57-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DNA Microarray Cluster Analysis Reveals Tissue Similarity and Potential Neuron-Specific Cenes Expressed in Cranial Sensory Canglia. (2003)
  • Author(s): Matsumoto, I., Emori, Y., Nakamura, S., Shimizu, K., Arai, S. Abe, K.
  • Journal Title: Journal of Neuroscience Research 74 Pages: 818-828
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Proteome Analysis Reveals Caspase Activation ii Hyporesponsive CD4 T Lymphocytes Induced in Vivoby the Oral Administration of Antigen. (2003)
  • Author(s): Kaji, T., Hachimura, S., Ise, W. Kaminogawa, S.
  • Journal Title: The Joiumal of Biological Chemistry 278 Pages: 27836-27843
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Proteome database of unsensitized CD4 positive lymphocytes in T cell receptor transgenic mice. (2003)
  • Author(s): Kaji, T., Hachimura, S. Kaminogawa, S.
  • Journal Title: TElectrophoresis 24 Pages: 3433-3444
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CDI lhr Peyer's Patch Dendritic Cells Secrete IL-S and Induce lgA Secretion from Nalve B Cells. (2003)
  • Author(s): Sato, A., Hashiguchi, M., Toda, E., Iwasalci, A., Hachimura, S. Kaminogawa, S.
  • Journal Title: The Journal of Immunology 171 Pages: 3684-3690
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] P13K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. (2003)
  • Author(s): Suzuki, H., Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T. W., Kouro, T., Takatsu, K., Kadowaki, T. Koyasu, S.
  • Journal Title: Nature Immunology 4 Pages: 280-286
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Role of Cryptopatch-Derived Intraepithellal Lymphocytes in the Development of Chronic Ileocecitis. (2003)
  • Author(s): Makita, S., Kanal, T., Matsumoto, S., Iivama, R., Uraushihara, K., Totsuka, T., Yamazaki, M., Nakamura, T., Ishikawa, H. Watanabe, M.
  • Journal Title: Scandinavian Journal of Immunology 58 Pages: 428-435
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine (2002)
  • Author(s): Hamada, H
  • Journal Title: The Journal of Immunology 168 Pages: 57-64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Homeostatic Regulation of Intestinal Villous Epithelia by B Lymphocytes (2002)
  • Author(s): Nishiyama, Y
  • Journal Title: The Journal of Immunology 168 Pages: 2626-2633
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Stabilization of mast cells by heme oxygenase-1:an anti-inflammatory role (2002)
  • Author(s): Takamiya, R
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology 283 Pages: H861-H870
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nonendothelial Source of Nitric Oxide in Arterioles But Not in Venules.Alternative Source Revealed In Vivo by Diaminofluorescein MicrofluOrography (2002)
  • Author(s): Kashiwagi, S
  • Journal Title: Circulation Research 91 Pages: e55-e64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract (2002)
  • Author(s): Okamoto, R
  • Journal Title: Nature Medicine 8 Pages: 1011-1017
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical Role for IL-15 in Innate Immunity (2002)
  • Author(s): Ohteki, T
  • Journal Title: Current Molecular Medicine 2 Pages: 371-380
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] PI3K-mediated negative feedback regulation of IL-12 production in DCs (2002)
  • Author(s): Fukao, T
  • Journal Title: Nature Immunology 3 Pages: 875-881
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of Multiple Isolated Lvmphojd Follicles on the Antimesenteric Wall of the Mouse Small Intestine. (2002)
  • Author(s): Hamada, H., Hiroi, T., Nishiyama, Y., Takahashi, H., Masunaga, Y., Hachimura, S., Kaminogawa, S., Takaliashi-Iwanaga H., lwanaga, T., Kiyono, H., Yamamoto, H. and Ishikawa, H.
  • Journal Title: The Journal of Immunology 168 Pages: 57-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] H omeostatic Regulation of Intestinal Vlllous Epithella by B Lymphocytes. (2002)
  • Author(s): Nishiyama, Y., Hamada, H., Nonaka, S., Yaroamoto., Nanno, M., Katayan-ja, Y., Takahashi, H. And Ishikawa, H.
  • Journal Title: The Journal of Immunology 68 Pages: 2626-2633
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stabilization of mast cells by heme oxygenase-1 : an anti-inflammatory role. (2002)
  • Author(s): Takamiya, R., Muralcami, M., Ka, umura, M., Coda, N., Makino, N., Takamiya, Y., Yamaguchi, T., Ishimura, Y., Hozumi, N., M.
  • Journal Title: American Journal of Physiology -Heart and Circulatory Physiology 283 Pages: H861-H870
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nonendothellal Source of Nitric Qinde in Arterioles But Not in Venujes, Alternative Source Revealed In Vivo by Diaminofluorescein Microfluorographv. (2002)
  • Author(s): Kashiwagi, S., Kajimura, M., Yoshimura, Y. Suematsu, M.
  • Journal Title: Circulation Research 91 Pages: e55-e64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Damaged epithella regenerated by bone marrow-derived cells in the human gastrointestinal tract. (2002)
  • Author(s): Okamoto, R., Yajima, T., Yamazalci, M., Kanai, T., Mukai, M., Okamoto, S., Ikeda, Y., Hibi, T., Inazawa, J., Watanabe, M.
  • Journal Title: Nature Medicine 8 Pages: 1011-1017
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical Role for IL-IS in Innate Immunity. (2002)
  • Author(s): Ohteki, T.
  • Journal Title: Current Molecular Medicine 2 Pages: 371-380
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] P13K-mediated negative feedback regulation of IL-12 production in DCs. (2002)
  • Author(s): Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowalci, T., Takeuchi, T., Koyasu, S.
  • Journal Title: Nature Immunology 3 Pages: 875-881
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical role of IL-15-IL-15R for antigen-presenting cellfunctions in the innate immune response (2001)
  • Author(s): Ohteki, T
  • Journal Title: Nature Immunology 2 Pages: 1138-1143
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response (2001)
  • Author(s): Ohteki, T., Suzue, K., Maid, C., Ota, T. and Koyasu, IS.
  • Journal Title: Nature Immunology 2 Pages: 1138-1143
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Mucosal Immunology (2005)
  • Author(s): Ishikawa, H
  • Total Pages: 385-405
  • Publisher: Academic Press
  • Description: 「研究成果報告書概要(和文)」より