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2004 Fiscal Year Final Research Report Summary

Primate Comparative Genome Analysis and Study on Mechanisms of Human Evolution

Research Project

Project/Area Number 14011248
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Genetics

Principal Investigator

SAITOU Naruya  National Institute of Genetics, Department of Population Genetics, Professor, 集団遺伝研究, 教授 (30192587)

Co-Investigator(Kenkyū-buntansha) FUJIYAMA Asao  National Institute of Informatics, Foumdations of Informatics Research Division, Professor, 学術研究情報研究系, 教授 (60142311)
Project Period (FY) 2002 – 2004
Keywordshuman evolution / molecular evolution / ehromnsorne / ape / genome evolution
Research Abstract

Our most prominent achievement was determination and evolutionary analysis of chimpanzee chromosome 22 long arm genomic sequences, published in Nature in 2004. Saitou and Fujiyama were both corresponding authors of this paper. Detailed difference on amino acid sequences and genomic sequences were delineated. In particular, clear difference between insertion and deletion was discovered. We also used chimpanzee genome sequence as outgroup to infer direction of mutations that created human SNP, and estimated nucleotide substitution patterns. Another large scale study was determination of BAC-end sequences of chimpanzee BAC library, and human-chimpanzee difference in terms of nucleotide substitution was determined to be 1.23% (Fujiyama et al., Science, 2002). Gorilla fosmid library was also constructed (Kim et al., Genomics,2003).
We also compared 103 protein coding gene sequences for human, chimpanzee, gorilla, and orangutan (Kitano et al., Molecular Biology and Evolution, 2004). Various statistical tests were used to detect human specific changes, but each test picked up different set of genes. Other results include various types of human and ape comparison on SCA triplet repeat polymorphism (Andres et al, Journal of Molecular Evolution) and polyubiquitin (Tachikui et al., Journal of Molecular Evolution), as well as mitochondrial DNA polymorphism study on African wild chimpanzees (Shimada et al., American Journal of Primatology).

  • Research Products

    (31 results)

All 2005 2004 2003 2002

All Journal Article (30 results) Book (1 results)

  • [Journal Article] Evolution of hominoids and the search for a genetic basis for sreating humanness.2005

    • Author(s)
      Saitou N.
    • Journal Title

      Cytogenetic and Genome Research 108

      Pages: 16-21

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hagfish Leukocytes Express a Paired Receptor Family with a Variable Domain Resembling Those of Antigen Receptors.2005

    • Author(s)
      Suzuki T.
    • Journal Title

      J. Immunol. 174

      Pages: 2885-2891

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evolution of hominoids and the search for a genetic basis for creating humanness.2005

    • Author(s)
      Saitau N. et al.
    • Journal Title

      Cytogenetic and Genome Research vol.108

      Pages: 16-21

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hagfish Leukocytes Express a Paired Receptor Family with a Variable Domain Resembling Those of Antigen Receptors.2005

    • Author(s)
      Suzuki 7'. et al.
    • Journal Title

      J. Immunol. vol.174

      Pages: 2885-2891

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Human specific amino acid changes found in 103 protein coding genes.2004

    • Author(s)
      Kitano T.
    • Journal Title

      Mol. Biol. Evol. 21

      Pages: 936-944

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNA sequence and comparative analysis of chimpanzee chromosome 22.2004

    • Author(s)
      Watanabe H.
    • Journal Title

      Nature 429

      Pages: 382-388

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lineage specific homogenization of the polyubiquitin gene among human and great apes.2004

    • Author(s)
      Tachikui H.
    • Journal Title

      J. Mol. Evol. 57

      Pages: 737-744

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Construction of a bacterial artificial chromosome library from the inshore hagfish, Eptatretus burgeri : A resourece for the analysis of the agnathan genome.2004

    • Author(s)
      Suzuki T.
    • Journal Title

      Genes & Genetic Systems 79

      Pages: 251-253

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Human specific amino acid changes found in 103 protein coding genes.2004

    • Author(s)
      Ritmo-T. et al.
    • Journal Title

      Mol. Biol. Evol. Vol.21

      Pages: 404-409

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] DNA sequence and comparative analysis of chimpanzee chromosome 22.2004

    • Author(s)
      The International Chimpanzee Chromosome 22 Consortium Watanabe H. et al.
    • Journal Title

      Nature vol.429

      Pages: 382-388

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lineage specific homogenization of the polyubiquitin gene among human and great apes.2004

    • Author(s)
      Tachikui H. at al.
    • Journal Title

      J. Mol. Evol. vol.57

      Pages: 737-744

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Construction of a bacterial artificial chromosome library from the inshore hagfish, Eptatretus burgeri Aresource for the analysis of the agnathan genome.2004

    • Author(s)
      Suzuki T. et al.
    • Journal Title

      Genes & Genetic Systems vol,79

      Pages: 251-253

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Construction of a gorilla fosmid library and its PCR screening system.2003

    • Author(s)
      Kim C.-G.
    • Journal Title

      Genomics 82

      Pages: 571-574

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evolution of the cystatin B gene : implications for the origin of its variable dodecamer tandem repeat in humans.2003

    • Author(s)
      Osawa M.
    • Journal Title

      Genomics 81

      Pages: 78-84

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Understanding the dynamics of Spinocerebellar Ataxia 8 (SCA8) locus through a comparative genetic approach in humans and apes.2003

    • Author(s)
      Andres A. M.
    • Journal Title

      Neuroscience Letters 336

      Pages: 143-146

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Construction of a BAC library for Haplochromis chilotes, a cichlid fish from Lake Victoria.2003

    • Author(s)
      Watanabe M.
    • Journal Title

      Genes Genet. Syst. 78

      Pages: 103-105

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Construction of a gorilla fosmid library and its PCR screening system.2003

    • Author(s)
      Kim C.-G.et al.
    • Journal Title

      Genomics vol.82

      Pages: 571-574

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Evolution-of the cystatin B gene : implications for the origin of its variable dodecamer tandem repeat in humans.2003

    • Author(s)
      Osawa M. at al.
    • Journal Title

      Genomics vol.81

      Pages: 78-84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Understanding the dynamics of Spinocerebellar Ataxia8 (SCAB) locus through a comparative genetic approach in humans and apes.2003

    • Author(s)
      Andrea A.M.et al.
    • Journal Title

      Neuroscience Letters vol.336

      Pages: 143-146

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Construction of a BAC library for Haplochromis chilotes, a cichlid fish from Lake Victoria.2003

    • Author(s)
      Watanabe M. et al.
    • Journal Title

      Genes Genet. Syst. vol.78

      Pages: 103-105

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] NJML+P : A Hybrid Algorithm of the Maximum Likelihood and Neighbor-Joining Methods Using Parallel Computing.2002

    • Author(s)
      Oota S.
    • Journal Title

      Proceedings of Genome Informatics 13

      Pages: 434-435

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Construction and Analysis of a Human-Chimpanzee Comparative Clone Map.2002

    • Author(s)
      Fujiyama A.
    • Journal Title

      Science 295

      Pages: 131-134

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Point Matching Under Non-Uniform Distortions and Protein Side Chain Packing Based on an Efficient Maximum Clique Algorithm.2002

    • Author(s)
      Bahadur D.
    • Journal Title

      Genome Informatics 13

      Pages: 143-152

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of Two novel primate-specific genes in DSCR.2002

    • Author(s)
      Takamatsu K.
    • Journal Title

      DNA Research 9

      Pages: 89-97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Chromosome-wide assessment of replication timing for human chromosomes 11q and 21q : disease-related genes in timing -switch regions.2002

    • Author(s)
      Watanabe Y.
    • Journal Title

      Human Molecular Genetics 11

      Pages: 13-21

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] NJML+P : A Hybrid Algorithm of The Maximum Likelihood and Neighbor-Joining Methods Using Parallel Computing.2002

    • Author(s)
      OOta S.et al.
    • Journal Title

      Proceedings of Genome Informatics vol.13

      Pages: 434-435

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Construction and Analysis of a Human-Chimpanzee Comparative Clone Map.2002

    • Author(s)
      Fujiyama A at al.
    • Journal Title

      Science vol.295

      Pages: 131-134

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Point Matching Under Non-Uniform Distortions and Protein Side Chain Packing Based on an Efficient Maximum Clique Algorithm2002

    • Author(s)
      Bahadur D. et al.
    • Journal Title

      Genome Informatics vol.13

      Pages: 143-152

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of Two novel primate-specific genes in DSCR.2002

    • Author(s)
      Takamatsu K. et al.
    • Journal Title

      DNA Research vol.9

      Pages: 89-97

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chromosome-wide assessment of replication timing for human chromosomes 11q and 21q : disease-related genes in timing-switch regions.2002

    • Author(s)
      Watanabe Y. et al.
    • Journal Title

      Human Molecular Genetics vol.11

      Pages: 13-21

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] ゲノウと進化-ゲノムから立ち昇る生命-2004

    • Author(s)
      斎藤 成也
    • Total Pages
      210
    • Publisher
      新曜社
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

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