2005 Fiscal Year Final Research Report Summary
Influenza virus : the mechanism of genome packaging
| Project/Area Number |
14021013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tokyo |
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Principal Investigator |
KAWAOKA Yoshihiro University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (70135838)
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| Project Period (FY) |
2002 – 2005
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| Keywords | virus / influenza virus / genome / packaging / reverse genetics |
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| Research Abstract |
The genome of influenza A viruses comprises eight negative-strand RNA segments. Although all eight segments must be present in cells for efficient viral replication, the mechanism(s) by which these viral RNA (vRNA) segments are incorporate into virions is not fully understood. In this study, we found that sequences at both ends of the coding and noncoding regions of all eight segments of A/WSN/33 play important roles in the incorporation of these vRNAs into influenza virions. Indeed, electron microscopy of influenza A virus has revealed that budding virions contain eight ribonucleoprotein (RNP) molecules, indicating that the RNPs likely assemble to form a multisegmented macromolecule. These findings indicated that the genome packaging steps could be excellent targets for the development of antiviral compounds.
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[Journal Article] Y Hierarchy among vRNA segments in their role in vRNA incorporation into influenza A virions.2006
Author(s)
Muramoto, Y, Takada, A., Fujii, K., Noda, T., Iwatsuki- Horimoto, K., Watanabe, S., Horimoto, T., Kida, H., Kawaoka
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Journal Title
J. Virol. 80
Pages: 2318-2325
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Y Architecture of ribonucleoprotein complexes in influenza A virus particles.2006
Author(s)
Noda, T., Sagara, H., Yen, A., Takada, A., Kida, A., Cheng, RH., Kawaoka
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Journal Title
Nature 439
Pages: 490-492
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Y Importance of both the coding and the segment-specific noncoding resions of the influenza A virus NS segment for its efficient incorporation into virions.2005
Author(s)
Fujii, K., Fujii, Y, Noda, T., Muramoto, Y, Watanabe, T., Takada, A., Goto, H., Horimoto, T., Kawaoka
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Journal Title
J. Virol. 79
Pages: 3766-3774
Description
「研究成果報告書概要(欧文)」より
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