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2005 Fiscal Year Final Research Report Summary

Elucidation and conquest of S. aureus antibiotic resistance based on the whole genome sequence information

Research Project

Project/Area Number 14021113
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research Institutionuntendo University

Principal Investigator

HIRAMATSU Keiichi  Juntendo University, School of Medicine, Professor, 医学部, 教授 (10173262)

Project Period (FY) 2002 – 2005
KeywordsMRSA / Vancomycin resistance / SCC / oriC environ / clogging of peptidoglycan / Staphylococcus aureus / Staphylococcus haemolvticus / Whole eenome seauencine
Research Abstract

1) Novel mechanism of glycopeptide resistance of Vancomycin-Intermediate S.aureus (VISA)
We used experimental and mathematical approach to prove Clogging mechanim of vancomycin resistance.
2) Indentification of novel genes which are responsible for glycopeptide resistance of Staphylococcus aureus. Two component systems vraSR and graSR are involved in the mechanism.
3) Identification of a novel chromosomal region " oriC environ" where alien genes are accumulated presumably by SCC (Staphylcoccal cassette chromosome)-mediated horizontal gene transfer. We proposed that the region is directly involved in the evolution and speciation of Staphylococcus species.

  • Research Products

    (30 results)

All 2006 2005 2004

All Journal Article (30 results)

  • [Journal Article] Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.2006

    • Author(s)
      Cui L, et al.
    • Journal Title

      Antimicrob Agents Chemother. 50.3

      Pages: 1079-1082

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus.2006

    • Author(s)
      Cui L, et al.
    • Journal Title

      Antimicrob Agents Chemother. 50.2

      Pages: 428-438

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cross-resistance of vancomycin-intermediate Staphylococcus aureus to daptomycin and vancomycin.2006

    • Author(s)
      Cui L, Tominaga E, Neoh Hui-min, Hiramatsu K.
    • Journal Title

      Antimicrob Agents Chemother 50

      Pages: 1079-1082

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel Mechanism of Antibiotic Resistance Originating in Vancomycin-Intermediate Staphylococcus aureus2006

    • Author(s)
      Cui L, Iwamoto A, Lian J-Q, Neoh Hui-min, Maruyama T, Horikawa Y, Hiramatsu K.
    • Journal Title

      AAC 50

      Pages: 428-438

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus.2005

    • Author(s)
      Watanabe S, et al.
    • Journal Title

      J Bacteriol. 187.11

      Pages: 3698-3707

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay.2005

    • Author(s)
      Ma XX, et al.
    • Journal Title

      Emerg Infect Dis. 11.6

      Pages: 973-976

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dissemination of methicillin-resistant staphylococci among healthy Japanese children.2005

    • Author(s)
      Hisata K, et al.
    • Journal Title

      J Clin Microbiol. 43.7

      Pages: 3364-3372

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant staphylococcus aureus in a Turkish university hospital : brief report of a surveillance study2005

    • Author(s)
      Torun MM, et al.
    • Journal Title

      International Journal of Antimicrobial Agents 26.6

      Pages: 508-510

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Genetic Differentiation of Methicillin-Resistant Staphylococcus aureus Strains from Korea and Japan2005

    • Author(s)
      Kwan Soo Ko, et al.
    • Journal Title

      Microbial Drug Resistance 11.3

      Pages: 279-286

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNA micro array-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.2005

    • Author(s)
      Cui L, et al.
    • Journal Title

      Antimicrob Agents Chemother 49.8

      Pages: 3404-3413

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Antibacterial Activity of Dipropofol and Related Compounds2005

    • Author(s)
      Ogata M, et al.
    • Journal Title

      Biological & Pharmaceutical Bulletin 28.6

      Pages: 1120-1122

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacΑ/Βand smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 19992005

    • Author(s)
      Noguchi N, et al.
    • Journal Title

      J Med Microbiol 54

      Pages: 557-565

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.2005

    • Author(s)
      Takeuchi F.
    • Journal Title

      J Bacteriol. 187.21

      Pages: 7292-7308

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 臨床分離株に対するdoripenenの抗菌力2005

    • Author(s)
      桑原京子 他
    • Journal Title

      日本化学療法誌 53.S-1

      Pages: 17-23

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in a Turkish university hospital : brief report of a surveillance study.2005

    • Author(s)
      Torun MM, Bahar H, Demirci M, Altas K, Bagdatli Y, Kocazeybek B, Kapi M, Hiramatsu K.
    • Journal Title

      Int J Antimicrob Agents. 26

      Pages: 508-10

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Heterogeneous vancomy cin-resistant Staphylococcus aureus (hetero-VISA) in Singapore.2005

    • Author(s)
      Sng LH, Koh TH, Wang GC, Hsu LY, Kapi M, Hiramatsu K.
    • Journal Title

      Int J Antimicrob Agents. 25

      Pages: 177-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genetic differentiation of methicillin-resistant Staphylococcus aureus strains from Korea and Japan.2005

    • Author(s)
      Soo Ko K, Peck KR, Sup Oh W, Lee NY, Hiramatsu K, Song JH.
    • Journal Title

      Microb Drug Resist. 11

      Pages: 279-86

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.2005

    • Author(s)
      Cui L, Lian JQ, Neoh HM, Reyes E, Hiramatsu K.
    • Journal Title

      Antimicrob Agents Chemother. 49

      Pages: 3404-13

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dissemination of methicillin-resistant staphylococci among healthy Japanese children.2005

    • Author(s)
      Hisata K, Kuwahara-Arai K, Yamanoto M, Ito T, Nakatomi Y, Cui L, Baba T, Terasawa M, Sotozono C, Kinoshita S, Yamashiro Y, Hiramatsu K.
    • Journal Title

      J Clin Microbiol. 43

      Pages: 3364-72

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Community-acquired methicillin-resistant Staphylococcus aureus,Uruguay.2005

    • Author(s)
      Ma XX, Galiana A, Pedreira W, Mowszowicz M, Christophersen I, Machiavello S, Lope L, Benaderet S, Buela F, Vincentino W, Albini M, Bertaux 0, Constenla I, Bagnulo H, Llosa L, Ito T, Hiramatsu K.
    • Journal Title

      Emerg Infect Dis.Erratum in : Emerg Infect Dis 1111

      Pages: 973-61329

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Antibacterial activity of dipropofol and related compounds.2005

    • Author(s)
      Ogata M, Tutumimoto Sato K, Kunikane T, Oka K, Seki M, Urano S, Hiramatsu K, Endo T.
    • Journal Title

      Biol Pharm Bull. 28

      Pages: 1120-2

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus.2005

    • Author(s)
      Watanabe S, Ito T, Takeuchi F, Endo M, Okuno E, Hiramatsu K.
    • Journal Title

      J Bacteriol. 187

      Pages: 3698-707

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin- resistant Staphylococcus aureus isolated in Asia during 1998 and 1999.2005

    • Author(s)
      Noguchi N, Suwa J, Narui K, Sasatsu M, Ito T, Hiramatsu K, Song JH.
    • Journal Title

      J Med Microbiol. 54

      Pages: 557-65

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.2005

    • Author(s)
      Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K.
    • Journal Title

      J Bacteriol. 187

      Pages: 7292-308

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions.2005

    • Author(s)
      Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M.
    • Journal Title

      Inflamm Res. 54

      Pages: 66-73

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genetic characterization of methicillin-resistant Staphylococcus aureus.2004

    • Author(s)
      Hiramatsu K, Watanabe S, Takeuchi F, Ito T, Baba T.
    • Journal Title

      Vaccine. 22 Suppl

      Pages: 1:S5-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Asian Network for Surveillance of Resistant Pathogens Study Group. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin.2004

    • Author(s)
      Song JH, Hiramatsu K, Suh JY, Ko KS, Ito T, Kapi M, Kiem S, Kim YS, Oh WS, Peck KR, Lee NY
    • Journal Title

      Antimicrob Agents Chemother 48

      Pages: 4926-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Has vancomycin-resistant Staphylococcus aureus started going it alone?2004

    • Author(s)
      Hiramatsu K, Cui L, Kuwahara-Arai K.
    • Journal Title

      Lancet. 364

      Pages: 565-6

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC.2004

    • Author(s)
      Ito T, Ma XX, Takeuchi F, Okuma K, Yuzawa H, Hiramatsu K.
    • Journal Title

      Antimicrob Agents Chemother 48

      Pages: 2637-51

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315.2004

    • Author(s)
      Ohta T, Hirakawa H, Morikawa K, Maruyama A, Inose Y, Yamashita A, Oshima K, Kuroda M, Hattori M, Hiramatsu K, Kuhara S, Hayashi H.
    • Journal Title

      DNA Res. 29

      Pages: 51-6

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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