2005 Fiscal Year Final Research Report Summary
Elucidation and conquest of S. aureus antibiotic resistance based on the whole genome sequence information
| Project/Area Number |
14021113
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | untendo University |
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Principal Investigator |
HIRAMATSU Keiichi Juntendo University, School of Medicine, Professor, 医学部, 教授 (10173262)
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| Project Period (FY) |
2002 – 2005
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| Keywords | MRSA / Vancomycin resistance / SCC / oriC environ / clogging of peptidoglycan / Staphylococcus aureus / Staphylococcus haemolvticus / Whole eenome seauencine |
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| Research Abstract |
1) Novel mechanism of glycopeptide resistance of Vancomycin-Intermediate S.aureus (VISA)
We used experimental and mathematical approach to prove Clogging mechanim of vancomycin resistance.
2) Indentification of novel genes which are responsible for glycopeptide resistance of Staphylococcus aureus. Two component systems vraSR and graSR are involved in the mechanism.
3) Identification of a novel chromosomal region " oriC environ" where alien genes are accumulated presumably by SCC (Staphylcoccal cassette chromosome)-mediated horizontal gene transfer. We proposed that the region is directly involved in the evolution and speciation of Staphylococcus species.
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[Journal Article] Dissemination of methicillin-resistant staphylococci among healthy Japanese children.2005
Author(s)
Hisata K, Kuwahara-Arai K, Yamanoto M, Ito T, Nakatomi Y, Cui L, Baba T, Terasawa M, Sotozono C, Kinoshita S, Yamashiro Y, Hiramatsu K.
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Journal Title
J Clin Microbiol. 43
Pages: 3364-72
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Community-acquired methicillin-resistant Staphylococcus aureus,Uruguay.2005
Author(s)
Ma XX, Galiana A, Pedreira W, Mowszowicz M, Christophersen I, Machiavello S, Lope L, Benaderet S, Buela F, Vincentino W, Albini M, Bertaux 0, Constenla I, Bagnulo H, Llosa L, Ito T, Hiramatsu K.
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Journal Title
Emerg Infect Dis.Erratum in : Emerg Infect Dis 1111
Pages: 973-61329
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.2005
Author(s)
Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K.
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Journal Title
J Bacteriol. 187
Pages: 7292-308
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Asian Network for Surveillance of Resistant Pathogens Study Group. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin.2004
Author(s)
Song JH, Hiramatsu K, Suh JY, Ko KS, Ito T, Kapi M, Kiem S, Kim YS, Oh WS, Peck KR, Lee NY
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Journal Title
Antimicrob Agents Chemother 48
Pages: 4926-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315.2004
Author(s)
Ohta T, Hirakawa H, Morikawa K, Maruyama A, Inose Y, Yamashita A, Oshima K, Kuroda M, Hattori M, Hiramatsu K, Kuhara S, Hayashi H.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
