2002 Fiscal Year Annual Research Report

悪性リンパ腫の地理病理学的、臨床病理学的研究

Research Project

Project/Area Number	14031225
Research Institution	Aichi Cancer Center Research Institute
Principal Investigator	中村栄男愛知県がんセンター, 研究所, 研究員 (80180363)
Keywords	Malignant lymphoma / International comparison / Germany / Korea / Diffuse large B-cell lymphoma / CD5 / API2-MALT1 / Peripheral T / NK-cell lymphoma
Research Abstract	本研究の目的は、本邦・欧米・韓国などの症例との厳密な比較検討を行い、悪性リンパ腫の地理的特性の解明を試みることにある。ドイツ国、H.K.Muller-Hermelink教授(Wuerzburg大学)(2002年5月)、韓国のC.W.Kim教授(ソウル国立大学)(2002年8月、2003年1月)と相互の病理診断の検証と各国の悪性リンパ腫特性の協議を行なった。その結果、現在のリンパ腫病学における問題点について共通の認識を有するに至った。現在、問題解決のために、特に末梢性T/NK細胞リンパ腫1,000例におけるバイオインフォマテックス解析による新分類画定のための共同研究の合意を得た。これを完遂することにより、悪性リンパ腫の地理病理学的、疫学的特性の差異が生物学的側面からより厳密に検証されるものと期待される。我々が世界に先駆け報告した新疾患単位群、特にblastic NK-cell lymphomaやintravascular lymphomatosisアジア亜型などについては未だ疾患自体の認識が十二分ではなく、今後に課題を残すこととなった。一方、年度内に新たな生物学的予後予測因子としてびまん性大細胞リンパ腫におけるCD5を発表するとともに、肺MALTリンパ腫におけるAPI2-MALT1遺伝子の臨床病理学的意義について新たな知見を加えた。CD5陽性びまん性B大細胞型リンパ腫については、その特殊性がドイツ国でも認識されつつあり、今後に国際比較研究に理解が得られた。

Research Products

(18 results)

All Other

All Publications (18 results)

[Publications] Okabe M, et al.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue"Am J Pathol. (in press). (2003)
[Publications] Oyama T, et al.: "Senile EBV^+ B-cell lymphoproliferative disorders : a clinicopathologic study of 22 patients"Am J Surg Pathol. 27. 16-26 (2003)
[Publications] Kojima M, et al.: "Primary pulmonary low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with prominent hyalinosis : a case report"Pathol Res Pract. 198. 685-688 (2002)
[Publications] Kojima M, et al.: "Lymph node infarction associated with infectious mononucleosis"Int J Surg Pathol. 10. 223-226 (2002)
[Publications] Kojima M, et al.: "Lymph node lesion in adult-onset Still's disease resembling peripheral T-cell lymphoma : a report of three cases"Int J Surg Pathol. 10. 197-202 (2002)
[Publications] Kojima M, et al.: "Nodal marginal zone B-cell lymphoma resembling plasmacytoma arising from a plasma cell variant of localized Castlman's disease : a case report"APMIS. 110. 523-527 (2002)
[Publications] Yoshino T, et al.: "Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-lymphoma"Br J Haematol. 118. 482-487 (2002)
[Publications] Yago K, et al.: "Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type of the liver in a patient with hepatitis C virus infection"Leuk Lymphoma. 43. 1497-1500 (2002)
[Publications] Nakamura N, et al.: "The Distinction between Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma with c-myc Rearrangement"Mod Pathol. 15. 771-776 (2002)
[Publications] Kojima M, et al.: "Centroblastic and centroblastic/centrocytic lymphoma associated with a prominent epithelioid granulomatous response : a study of 50 cases"Mod Pathol. 15. 750-756 (2002)
[Publications] Igarashi T, et al.: "Factors affecting toxicity, response and progression-free survival in patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab"Ann Oncol. 13. 928-943 (2002)
[Publications] Ito M, et al.: "MUM/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)"Jpn J Cancer Res. 93. 685-694 (2002)
[Publications] Nakamura T, et al.: "Clinicopathologic comparison between the API2-MALT1 chimeric transcript-positive and -negative gastric low-grade B-cell lymphoma of MALT type"Jpn J Cancer Res. 93. 677-684 (2002)
[Publications] Terasawa T, et al.: "Failure to detect EBV DNA in plasma by real-time PCR in a case of EBV-associated posttransplantation lymphoproliferative disorder confined to the CNS"Int J Hematol. 75. 416-420 (2002)
[Publications] Niitsu N, et al.: "Simultaneous elevation of the serum concentrations of VEGF and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma"Eur J Haematol. 68. 91-100 (2002)
[Publications] Kojima M, et al.: "Follicular hyperplasia presenting with a marginal zone pattern in a reactive lymph node lesion"APMIS. 110. 325-331 (2002)
[Publications] Inagaki H, et al.: "Primary thymic extranodal marginal-zone B-cell lymphoma of MALT type exhibits distinctive clinicopathological and molecular features"Am J Pathol. 160. 1435-1443 (2002)
[Publications] Yamaguchi M, et al.: "De novo CD5-positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patienrs"Blood. 99. 815-821 (2002)

2002 Fiscal Year Annual Research Report

悪性リンパ腫の地理病理学的、臨床病理学的研究

Principal Investigator

中村 栄男 愛知県がんセンター, 研究所, 研究員 (80180363)

Research Products

[Publications] Okabe M, et al.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue"Am J Pathol. (in press). (2003)

[Publications] Oyama T, et al.: "Senile EBV^+ B-cell lymphoproliferative disorders : a clinicopathologic study of 22 patients"Am J Surg Pathol. 27. 16-26 (2003)

[Publications] Kojima M, et al.: "Primary pulmonary low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with prominent hyalinosis : a case report"Pathol Res Pract. 198. 685-688 (2002)

[Publications] Kojima M, et al.: "Lymph node infarction associated with infectious mononucleosis"Int J Surg Pathol. 10. 223-226 (2002)

[Publications] Kojima M, et al.: "Lymph node lesion in adult-onset Still's disease resembling peripheral T-cell lymphoma : a report of three cases"Int J Surg Pathol. 10. 197-202 (2002)

[Publications] Kojima M, et al.: "Nodal marginal zone B-cell lymphoma resembling plasmacytoma arising from a plasma cell variant of localized Castlman's disease : a case report"APMIS. 110. 523-527 (2002)

[Publications] Yoshino T, et al.: "Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-lymphoma"Br J Haematol. 118. 482-487 (2002)

[Publications] Yago K, et al.: "Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type of the liver in a patient with hepatitis C virus infection"Leuk Lymphoma. 43. 1497-1500 (2002)

[Publications] Nakamura N, et al.: "The Distinction between Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma with c-myc Rearrangement"Mod Pathol. 15. 771-776 (2002)

[Publications] Kojima M, et al.: "Centroblastic and centroblastic/centrocytic lymphoma associated with a prominent epithelioid granulomatous response : a study of 50 cases"Mod Pathol. 15. 750-756 (2002)

[Publications] Igarashi T, et al.: "Factors affecting toxicity, response and progression-free survival in patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab"Ann Oncol. 13. 928-943 (2002)

[Publications] Ito M, et al.: "MUM/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)"Jpn J Cancer Res. 93. 685-694 (2002)

[Publications] Nakamura T, et al.: "Clinicopathologic comparison between the API2-MALT1 chimeric transcript-positive and -negative gastric low-grade B-cell lymphoma of MALT type"Jpn J Cancer Res. 93. 677-684 (2002)

[Publications] Terasawa T, et al.: "Failure to detect EBV DNA in plasma by real-time PCR in a case of EBV-associated posttransplantation lymphoproliferative disorder confined to the CNS"Int J Hematol. 75. 416-420 (2002)

[Publications] Niitsu N, et al.: "Simultaneous elevation of the serum concentrations of VEGF and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma"Eur J Haematol. 68. 91-100 (2002)

[Publications] Kojima M, et al.: "Follicular hyperplasia presenting with a marginal zone pattern in a reactive lymph node lesion"APMIS. 110. 325-331 (2002)

[Publications] Inagaki H, et al.: "Primary thymic extranodal marginal-zone B-cell lymphoma of MALT type exhibits distinctive clinicopathological and molecular features"Am J Pathol. 160. 1435-1443 (2002)

[Publications] Yamaguchi M, et al.: "De novo CD5-positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patienrs"Blood. 99. 815-821 (2002)

中村栄男愛知県がんセンター, 研究所, 研究員 (80180363)