2006 Fiscal Year Final Research Report Summary
Regulative mechanisms of cell proliferation and differentiation by RNA-binding proteins
| Project/Area Number |
14035235
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kobe University |
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Principal Investigator |
SAKAMOTO Hiroshi Kobe University, Graduate School of Science, Professor (00187048)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Akira University of Tokyo, Molecular Genetics Research Laboratory, Research Associate (30312276)
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| Project Period (FY) |
2002 – 2006
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| Keywords | RNA-binding protein / neuronal cell / translational regulation / germ cell / rRNA processing / meiosis / mRNA decay |
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| Research Abstract |
We have shown the following findings :
1. Neuronal RNA-binding protein HuD acts as adaptor molecule for the general mRNA transport receptor TAP/NXF1. HuD also functions as a translational activator through interaction with both translation initiation factors and polyA-binding protein PABP.
2. EXC-7, a C. elegans homologue of HuD, is involved in the formation of the excretory canal.
3. An RNA-binding protein Y14, a component of exon-exon junction complex, is involved in the sexual differentiation of germ cells in C. elegans.
4. An RNA-binding protein RBD-1 is required for processing of 18S ribosomal RNA in C. elegans.
5. MRG-1, a C. elegans chromodomain protein, is a maternal factor which is required for germ cell formation and is involved in repression of sex chromosome gene expression.
6. Mmi1p, a S. pombe RNA-binding protein, functions to remove meiosis-specific mRNAs in mitotic stage cells.
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