2006 Fiscal Year Final Research Report Summary
Function regulation of proteins and molecular complexes with glycosylation.
| Project/Area Number |
14082101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
FURUKAWA Koichi Nagoya University, Graduates School of Medicine, Professor (80211530)
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| Co-Investigator(Kenkyū-buntansha) |
KIMATA Koji Aichi Medical University, Institute fo medicalScience, Professor (10022641)
KINOSHITA Taro Osaka University, Reserch Institute for Microbial Diseases, Professor (10153165)
MURAMATSU Takashi Aichi Gakuin University, Faculty of Psychologicaland Physical science, Professor (00030891)
KNNAGI Reiji Aichi Cancer Center, Molecular Pathology, General Manager (80161389)
KAWASAKI Toshisuke Ritsumeikan Asia Pacific University, Center of Glyootechnology, Professor (50025706)
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| Project Period (FY) |
2002 – 2007
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| Keywords | glycosylation / glycosyltransferase / glycoprotein / glycolinid / proteoglycan / signal / Knolout / bioreyulation |
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| Research Abstract |
For these 5 years, new paradigm of glycobiology has been established and understanding of molecular functions of carbohydrate chains in the complex carbohydrates have been achieved by integrating molecular biology, glycotechnology and structural biology based on the tradition of Japanese glyco-science and results of glyco-gene research. Consequently, integrated understanding of the glyco-functions largely proceeded, and importance of carbohydrates has been tremendously recognized.
As concrete items, 1. Idetification and analyses of novel sugar chains and glycosytransferase genes, and ligand genes; 2. Function analyses of knockout mice; 3. Identification of diseases based on the abnormal carbohydrates and/or glyco-genes; 4. Structural biology of carbohydrate synthesis and interaction between sugar-ligans, have been greatly developed. More over, linkage with researchers in related and unrelated areas has been strengthened and fusion researches have been developed. Various applied researches have been also started. As for growth of young researchers, many students and young researchers (150-200 peoples) attended the open symposia (5 times) and summer symposia (4 times), and grew up. Publishing News Letter (No. 1-9) and home page also supported their communication and promoted collaboration, leading to the creation of new glycobiology. In facts, papers (705), patents (56), knockout mice (25) were reported. Besides papers, our studies often became topics in various journals, indicating increased social attention to this field.
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