Identification of molecules involved in differentiation and immune regulation by NK-T cells

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 14104010
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: HOKKAIDO UNIVERSITY
• Principal Investigator: ONOE Kazunori Hokkaido University, Inst. Gene. Med., Prof, 遺伝子病制御研究所, 教授 (40002117)
• Co-Investigator(Kenkyū-buntansha): IWABUCHI Kazuya Hokkaido University, Inst. Gene. Med., Asso. Prof, 遺伝子病制御研究所, 助教授 (20184898) ; YANAGAWA Yoshiki Hokkaido University, Inst Gene. Med., Lec., 遺伝子病制御研究所, 助手 (20322852)
• Project Period (FY): 2002 – 2006
• Keywords: NK-T cell / dendritic cell / cytokine / Thl / Th2 balance / immune regulation / atherosclerosis / arthiritis / autoimmune diseases

Research Abstract

A new NK-T deficient strain of mice, SL/Kh, was found, where differentiation of NK-T cells was arrested at the CD40^<high> NK1.1-Ly49C/I-stage. Chemokine induced not only chemotaxis but also various functions, i.e. antigen uptake, in dendritic cells (DC), which present lipid antigens to NK-T cells (Blood 2002; 2003; Int. Immunol. 2005). DC functions to modulate Th differentiation were analyzed under different conditions (Immunology 2003a, b, c). It was found that different signal transduction systems were involved in the different cytokine productions in DC (Immunology 2006; J. Immunol. in press). Negative feed back regulation via cytokine was discovered between DC and NK-T cell interaction (Blood 2005). NK-T cells aggravated hepatitis by producing osteopontin (Immunity 2004). The osteopontin was also involved in aggravation of uveoretinitis model (J. Immunol. in press). In an arthritis model, however, NK-T cells ameliorated the clinical manifestation (Int. J. Mol. Med. 2006). Abnormal function of NK-T cells was observed in patients with Wegener's granulomatosis (Clin. Exp. Immunol. 2004). NK-T cells aggravated the atherosclerosis by producing IFN-y upon stimulation with oxidized low density lipoprotein (LDL) in murine atherosclerosis model.

Research Products

• [Journal Article] Enhanced IL-10 production by TLR4 and TLR2 primed dendritic cells upon TLR restimulation (2007)
  • Author(s): Yanagawa, Y.
  • Journal Title: J. Immunol. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Osteopontin aggravates experimental autoimmune uveoretinitis in mice (2007)
  • Author(s): Kitamura, M.
  • Journal Title: J. Immunol. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glycogen synthase kinase 3 activity during development of bone marrow derived dendritic cells (DC) essential for the DC function to induce T helper 2 polarization. (2007)
  • Author(s): Ono, T.
  • Journal Title: Immunology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] IL-21 enhances dendritic cell ability to induce interferon-γ production by natural killer T cells (2007)
  • Author(s): Maeda, M.
  • Journal Title: Immunobiology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Th1 or Th2 balance regulated by interaction between dendritic cells and NK-T cells (2007)
  • Author(s): Onoe, K.
  • Journal Title: Immunol. Res. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice (2007)
  • Author(s): Kitamei, H.
  • Journal Title: Immunobiology (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of NK-T-cell hybridomas expressing invariant T-cell antigen receptors (2007)
  • Author(s): Nyambayar, D.
  • Journal Title: J. Clin. Exp. Hematopathol. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of T helper 1 (Th1)/Th2 cytokine on chemokine -induced dendritic cell Functions (2006)
  • Author(s): Clingan, J.M.
  • Journal Title: Cell. Immunol. 242 Pages: 72-79
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Low-dose lipopolysaccharide modifies the production of IL-12 by dendritic cells in response to various cytokines (2006)
  • Author(s): Saito, Y.
  • Journal Title: J. Clin. Exp. Hematopathol. 46 Pages: 31-36
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct regulation of CD40-mediated interleukin (IL)-6 and IL-12 production via mitogen-activated protein kinase (MAPK) and nuclear factor κ B-inducing kinase (NIK) in mature dendritic cells. (2006)
  • Author(s): Yanagawa, Y.
  • Journal Title: Immunology 117 Pages: 526-535
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA (2006)
  • Author(s): Naito, M.
  • Journal Title: Gastroenterology 130 Pages: 1181-1190
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo (2006)
  • Author(s): Jin, X.H.
  • Journal Title: Exp. Eye Res. 82 Pages: 860-867
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Granulocytapheresis in patients with refractory ocular Behcet's disease (2006)
  • Author(s): Namba, K.
  • Journal Title: J. Clin. Apheresis. 21 Pages: 121-128
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor κ B (NF-κB), pyrrolidine dithiocarbamate (2006)
  • Author(s): Kitamei, H.
  • Journal Title: J. Leukoc. Biol. 79 Pages: 1193-1201
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice (2006)
  • Author(s): Takagi, D.
  • Journal Title: Int. J. Mol. Med. 18 Pages: 829-836
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural killer, natural killer T, helper and cytotoxic T cells in the decidua from sporadic miscarriage (2006)
  • Author(s): Shimada, S.
  • Journal Title: Am. J. Reprod. Immunol. 56 Pages: 193-200
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. (2006)
  • Author(s): Chan, C-F.R.
  • Journal Title: J. Allergy Clin. Immunol. 118 Pages: 455-465
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lower prevalence of circulating natural killer T cells in patients with angina : a potential novel marker for coronary artery disease (2006)
  • Author(s): Andoh, Y.
  • Journal Title: Coron. Artery Dis. 17 Pages: 523-528
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CCR7 ligands induce endocytosis and the formation of actin-filled ruffles in mature dendritic cells (2006)
  • Author(s): Yanagawa, Y.
  • Journal Title: J. Clin. Exp. Hematopathol. 45 Pages: 25-35
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of T helper 1 (Th1)/Th2 cytokine on chemokine-induced dendritic cell functions. (2006)
  • Author(s): Clingan, J.M., Yanagawa, Y., Iwabuchi, K., Onoe, K.
  • Journal Title: Cell. Immunol. 242 Pages: 72-79
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Low-dose lipopolysaccharide modifies the production of IL-12 by dendritic cells in response to various cytokines. (2006)
  • Author(s): Saito, Y., Yanagawa, Y., Kikuchi, K., Iijima, N., Iwabuchi, K., Onoe, K.
  • Journal Title: J. Clin. Exp. Hematopathol. 46 Pages: 31-36
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct regulation of CD40-mediated interleukin (IL)-6 and IL-12 production via mitogen-activated protein kinase (MAPK) and nuclear factor k B inducing kinase (NIK) in mature dendritic cells. (2006)
  • Author(s): Yanagawa, Y., Onoe, K.
  • Journal Title: Immunology 117 Pages: 526-535
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. (2006)
  • Author(s): Naito, M., Yamazaki, T., Tsutsumi, R., Higashi, H., Onoe, K., Yamazaki, S., Azuma, T., Hatakeyama, M.
  • Journal Title: Gastroenterology 130 Pages: 1181-1190
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo. (2006)
  • Author(s): Jin, X.H., Ohgami, K., Shiratori, K., Suzuki, Y., Koyama, Y., Yoshida, K., Ilieva, I., Tanaka, T., Onoe, K., Ohno, S.
  • Journal Title: Exp. Eye Res. 82(5) Pages: 860-867
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Granulocytapheresis in patients with refractory ocular Behcet's disease. (2006)
  • Author(s): Namba, K., Sonoda, K.H., Kitamei, H., Shiratori, K., Ariyama, A., Iwabuchi, K., Onoe, K., Saniabadi, A.R., Inaba, S., Ishibashi, T., Ohno, S.
  • Journal Title: J. Clin. Apheresis. 21 Pages: 121-128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor K B (NF-K B), pyrrolidine dithiocarbamate. (2006)
  • Author(s): Kitamei, H., Iwabuchi, K., Namba, K., Yoshida, K., Yanagawa, Y., Kitaichi, N., Kitamura, M., Ohno, S., Onoe K.
  • Journal Title: J. Leukoc. Biol. 79 Pages: 1193-1201
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. (2006)
  • Author(s): Takagi, D., Iwabuchi, K., Maeda, M., Nakamaru, Y., Furuta, Y., Fukuda, S., Van Kaer, L., Nishihira, J., Onoe, K.
  • Journal Title: Int. J. Mol. Med. 18 Pages: 829-836
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural killer, natural killer T, helper and cytotoxic T cells in the decidua from sporadic miscarriage. (2006)
  • Author(s): Shimada, S., Nishida, R., Takeda, M., Iwabuchi, K., Kishi, R., Onoe, K., Minakami, H., Yamada, H.
  • Journal Title: Am. J. Reprod. Immunol. 56 Pages: 193-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. (2006)
  • Author(s): Chan, C-F.R., Wang, M., Li, N., Yanagawa, Y., Onoe, K., Lee, J.J., Nel, A.E.
  • Journal Title: J. Allergy Clin. Immunol. 118 Pages: 455-465
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lower prevalence of circulating natural killer T cells in patients with angina : a potential novel marker for coronary artery disease. (2006)
  • Author(s): Andoh, Y., Fujii, S., Iwabuchi, K., Yokota, T., Inoue, N., Nakai, Y., Mishima, T., Yamashita, T., Nakagawa, T., Kitabatake, A., Onoe, K., Tsutsui, H.
  • Journal Title: Coron. Artery Dis. 17 Pages: 523-528
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CCR7 ligands-enhanced phagocytosis of various antigens in mature dendritic cells -Time course and antigen distribution different from phagocytosis in immature dendritic cells (2005)
  • Author(s): Kikuchi, K.
  • Journal Title: Microbiol. Immunol. 49 Pages: 535-544
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Negative feed back regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions (2005)
  • Author(s): Minami, K.
  • Journal Title: Blood 106 Pages: 1685-1693
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Protein phosphatase type 2A, PP2A, is involved in degradation of gp130 (2005)
  • Author(s): Mitsuhashi, S.
  • Journal Title: Mol. Cell Biochem. 269 Pages: 183-187
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells (2005)
  • Author(s): Iijima, N.
  • Journal Title: Int. Immunol. 17 Pages: 1201-1212
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Divergence of natural killer cell receptor and related molecule in the deciduas from sporadic miscarriage with normal chromosome karyotype (2005)
  • Author(s): Yamada, H.
  • Journal Title: Mol. Hum. Reprod. 11 Pages: 451-457
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Decrease in the glyceraldehyde derived advanced glycation end products in the sera of patients with Vogt-Koyanagi-Harada disease (2005)
  • Author(s): Kitamura, M.
  • Journal Title: Brit. J. Ophthalmol. 89 Pages: 1407-1409
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evidence of dual function of macrophage migration inhibitory factor relevant to tumor progression and regression (2005)
  • Author(s): Fukushima, T.
  • Journal Title: Int. J. Mol. Med. 16 Pages: 119-126
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CCR7 ligands induce endocytosis and the formation of actin-filled ruffles in mature dendritic cells. (2005)
  • Author(s): Yanagawa, Y., Onoe, K.
  • Journal Title: J. Clin. Exp. Hematopathol. 45 Pages: 25-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CCR7 ligands-enhanced phagocytosis of various antigens in mature dendritic cells -Time course and antigen distribution different from phagocytosis in immature dendritic cells. (2005)
  • Author(s): Kikuchi, K., Yanagawa, Y., Onoe, K.
  • Journal Title: Microbiol. Immunol. 49 Pages: 535-544
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Negative feed back regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions. (2005)
  • Author(s): Minami, K., Yanagawa, Y., Iwabuchi, K., Shinohara, N., Harabayashi, T., Nonomura, K., Onoe, K.
  • Journal Title: Blood 106 Pages: 1685-1693
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein phosphatase type 2A, PP2A, is involved in degradation of gp130. (2005)
  • Author(s): Mitsuhashi, S., Shima, H., Tanuma, N., Sasa, S., Onoe, K., Ubukata, M., Kikuchi, K.
  • Journal Title: Mol. Cell Biochem. 269 Pages: 183-187
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells. (2005)
  • Author(s): Iijima, N., Yanagawa, Y., Clingan, J.M., Onoe, K.
  • Journal Title: Int. Immunol. 17 Pages: 1201-1212
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Divergence of natural killer cell receptor and related molecule in the deciduas from sporadic miscarriage with normal chromosome karyotype. (2005)
  • Author(s): Yamada, H., Shimada, S., Morikawa, M., Iwabuchi, K., Kishi, R., Onoe, K., Minakami, H.
  • Journal Title: Mol. Hum. Reprod. 11 Pages: 451-457
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decrease in the glyceraldehyde derived advanced glycation end products in the sera of patients with Vogt-Koyanagi-Harada disease. (2005)
  • Author(s): Kitamura, M., Kitaichi, N., Takeuchi, M., Kitamei, H., Namba, K., Yamagishi, S., Iwabuchi, K., Onoe, K., Ohno, S.
  • Journal Title: Brit. J. Ophthalmol. 89 Pages: 1407-1409
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence of dual function of macrophage migration inhibitory factor relevant to tumor progression and regression. (2005)
  • Author(s): Fukushima, T., Nishihira, J., Yoshiki, T., Iwabuchi, K., Iwabuchi, C., Yamasaki, Y., Kondo, M., Sun, B., Sato, Y., Todo, S.
  • Journal Title: Int. J. Mol. Med 16 Pages: 119-126
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The NK-T cell as a new modifier of the development of atherosclerosis. (2005)
  • Author(s): Iwabuchi, K.
  • Journal Title: The Immuno-regulatory Role of Natural Killer T Cells in Inflammatory Disease (Ed. J.L.) (Croxford, Research Signpost, Kerala, India.) Pages: 51-69
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decrease in a specific killer cell immunoglobulin-like receptor on peripheral natural killer cells in women with recurrent spontaneous abortion of unexplained etiology. (2004)
  • Author(s): Yamada, H.
  • Journal Title: Am. J. Reprod. Immunol. 51 Pages: 241-247
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] No difference in natural killer or natural killer T-cell population, but aberrant T-helper cell population in the endometrium of women with repeated miscarriage (2004)
  • Author(s): Shimada, S.
  • Journal Title: Hum. Reprod. 19 Pages: 1018-1024
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Analysis of T cell responses to a superantigen, staphylococcal enterotoxin B (2004)
  • Author(s): Nagashima, T.
  • Journal Title: J. Clin. Exp. Hematopathol. 44 Pages: 25-32
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] T cell differentiation in allogeneic bone marrow chimeras (2004)
  • Author(s): Onoe, K.
  • Journal Title: Cancer Detect. Prev. Symposium Vol. Pages: 153-154
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunoregulatory defects of Vα24^+Vβ 11^+ NK-T cells in development of Wegener's granulomatosis and relapsing polychondritis (2004)
  • Author(s): Takagi, D.
  • Journal Title: Clin. Exp. Immunol. 136 Pages: 591-600
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] IL-7 dependent homeostasis proliferation in the presence of a large number of T cells in gld mice (2004)
  • Author(s): Aranami, T.
  • Journal Title: Microbiol. Immunol. 48 Pages: 477-484
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural killer T cells accelerate atherogenesis in mice (2004)
  • Author(s): Nakai, Y.
  • Journal Title: Blood 104 Pages: 2051-2059
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Rheumatoid factors induce signaling from B-cells, thus leading to Epstein-Barr virus and B-cell activation (2004)
  • Author(s): Yang, L.
  • Journal Title: J. Virol. 78 Pages: 9918-9923
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Osteopontin as a mediator of NK-T cell function in T cell mediated liver diseases (2004)
  • Author(s): Diao, H.
  • Journal Title: Immunity 21 Pages: 539-550
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The characterisitics of human NK-T cells in lung cancer - CD1d independent cytotoxicity against lung cancer cells by NK-T cells and decreased human NK-T cell response in lung cancer patients (2004)
  • Author(s): Konishi, J.
  • Journal Title: Hum. Immunol. 65 Pages: 1377-1388
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Decrease in a specific killer cell immunoglobulin-like receptor on peripheral natural killer cells in women with recurrent spontaneous abortion of unexplained etiology. (2004)
  • Author(s): Yamada, H., Shimada, S., Kato, E., Morikawa, M., Iwabuchi, K., Kishi, R., Onoe, K., Minakami, H.
  • Journal Title: Am. J. Reprod. Immunol. 51 Pages: 241-247
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] No difference in natural killer or natural killer T-cell population, but aberrant T-helper cell population in the endometrium of women with repeated miscarriage. (2004)
  • Author(s): Shimada, S., Kato, E.H., Morikawa, M., Iwabuchi, K., Nishida, R., Kishi, R., Onoe, K., Minakami, H., Yamada, H.
  • Journal Title: Hum. Reprod. 19 Pages: 1018-1024
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of T cell responses to a superantigen, staphylococcal enterotoxin B. (2004)
  • Author(s): Nagashima, T., Aranami, T., Iclozan, C., Ono6, K.
  • Journal Title: J. Clin. Exp. Hematopathol. 44 Pages: 25-32
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T cell differentiation in allogeneic bone marrow chimeras. (2004)
  • Author(s): Onoe, K., Iwabuchi, K., Good, R.A.
  • Journal Title: Cancer Detect. Prev., Symposium Vol. S-153-154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunoregulatory defects of V a 24+V β 11+ NK-T cells in development of Wegener's granulomatosis and relapsing polychondritis. (2004)
  • Author(s): Takagi, D., Iwabuchi, K., Iwabuchi, C., Nakamaru, Y., Maguchi, S., Ohwatari, R., Furuta, Y., Fukuda, S., Joyce, S., Onoe, K.
  • Journal Title: Clin. Exp. Immunol. 136 Pages: 591-600
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] IL-7 dependent homeostasis proliferation in the presence of a large number of T cells in gld mice. (2004)
  • Author(s): Aranami, T., Iclozan, C., Iwabuchi, K., Ono6, K.
  • Journal Title: Microbiol. Immunol. 48 Pages: 477-484
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural killer T cells accelerate atherogenesis in mice. (2004)
  • Author(s): Nakai, Y., Iwabuchi, K., Fujii, S., Ishimori, N., Watano, K., Mishima, T., Iwabuchi, C., Tanaka, S., Dashtsoodol, N., Nakayama, T., Taniguchi, M., Miyake, S., Yamamura, T., Kitabatake, A., Joyce, S., Van Kaer, L., Onoe, K.
  • Journal Title: Blood 104 Pages: 2051-2059
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rheumatoid factors induce signaling from B-cells, thus leading to Epstein-Barr virus and B-cell activation. (2004)
  • Author(s): Yang, L., Hakoda, M., Iwabuchi, K., Takeda, T., Koike, T., Kamatani, N., Takada, K.
  • Journal Title: J. Virol. 78 Pages: 9918-9923
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Osteopontin as a mediator of NK-T cell function in T cell mediated liver diseases. (2004)
  • Author(s): Diao, H., Kon, S., Iwabuchi, K., Kimura, C., Morimoto, J., Ito, D., Segawa, T., Maeda, M., Hamuro, J., Nakayama, T., Taniguchi, M., Yagita, H., Van Kaer, L., Onoe, K, Denhardt, D., Rittling, S., Uede, T.
  • Journal Title: Immunity 21 Pages: 539-550
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The characteristics of human NK-T cells in lung cancer-CD1d independent cytotoxicity against lung cancer cells by NK-T cells and decreased human NK-T cell response in lung cancer patients. (2004)
  • Author(s): Konishi, J., Yamazaki, K., Yokouchi, H., Shinagawa, N., Iwabuchi, K., Nishimura, M.
  • Journal Title: Hum. Immunol. 65 Pages: 1377-1388
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bone marrow cells differentiate into medullary thymic epithelial cells but not cortical thymic epithelial cells. (2004)
  • Author(s): Iclozan, C., Aranami, T., Iwabuchi, K., Onoe, K.
  • Journal Title: 12^<th> International Congress of Immunology and 4^<th> Annual Conference of FOCIS (Medimond S.r.1 Bologna, Italy) Pages: 187-190
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor (2003)
  • Author(s): Nagafuku, M.
  • Journal Title: J. Biol. Chem. 278 Pages: 51920-51927
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Decrease in a specific killer cell immunoglobulin-like receptor on peripheral natural killer cells in women with recurrent miscarriage of unexplained etiology. (2003)
  • Author(s): Yamada, H.
  • Journal Title: Am. J. Reprod. Immunol. 50 Pages: 149-154
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of early and late phase activation of p38 MARK induced by TNF-α or 2,4-dinitrobenzene during maturation of dendritic cells (2003)
  • Author(s): Iijima, N.
  • Journal Title: Immunology 110 Pages: 322-328
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Selective regulation of CD40 expression in murine dendritic cells by thiol antioxidants (2003)
  • Author(s): Iijima, N.
  • Journal Title: Immunology 110 Pages: 197-203
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of histamine on functional maturation of dendritic cells (2003)
  • Author(s): Pavlinkova, G.
  • Journal Title: Immunobiology 207 Pages: 315-325
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Allograft inflammatory factor-1 (AIF-1) regulates trinitrobenzene sulfonic asid (TNBS) -induced colitis (2003)
  • Author(s): Morohashi, T.
  • Journal Title: Immunology 110 Pages: 112-119
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells (2003)
  • Author(s): Kikuchi, K.
  • Journal Title: Immunol. Lett. 89 Pages: 149-154
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Impaired degradation of IκB and β-catenin as a result of targeted disruption of the βTrCP1 gene (2003)
  • Author(s): Nakayama, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 100 Pages: 8752-8757
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis (2003)
  • Author(s): Tosa, N.
  • Journal Title: Int. Immunol. 15 Pages: 741-749
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities (2003)
  • Author(s): Yanagawa, Y.
  • Journal Title: Blood 101 Pages: 4923-4929
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] No difference in natural-killer-T cell population, but Th2/Tc2 predominance in peripheral blood of recurrent aborters (2003)
  • Author(s): Shimada, S.
  • Journal Title: Am. J. Repro. Immunol. 50 Pages: 334-339
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of allograft inflammatory factor-1 in mouse uterus and poly (I : C) -induced fetal resorption (2003)
  • Author(s): Shimada, S.
  • Journal Title: Am. J. Repro. Immunol. 50 Pages: 104-112
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Positive and negative selection of T cell repertoires during differentiation in allogeneic bone marrow chimeras (2003)
  • Author(s): Onoe, K.
  • Journal Title: Transplant Immunol. 12 Pages: 79-88
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunology and functional genomics of Behcet's disease (2003)
  • Author(s): Zierhut, M.
  • Journal Title: Cell. Mol. Life Sci. 60 Pages: 1903-1922
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tumour necrosis factor-αbut not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation (2003)
  • Author(s): Kikuchi, K.
  • Journal Title: Immunology 108 Pages: 42-49
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NK and NK-T cells possibly involved in Behcet's Disease. (2003)
  • Author(s): Onoe, K., Kitaichi, N., Ohno, S., Iwabuchi, C., Iwabuchi, K.
  • Journal Title: Immunology of Behcet's Disease (Eds. by Zierhut, M., Ohno, S.) (Swets ＆ Zeitlinger, Lisse, The Netherlands.) Pages: 63-72
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. (2003)
  • Author(s): Nagafuku, M., Kabayama, K., Oka, D., Kato, A., Tani-ichi, S., Shimada, Y., Ohno-Iwashita, Y., Yamasaki, S., Saito, T., Iwabuchi, K., Hamaoka, T., Inokuchi, J., Kosugi, A.
  • Journal Title: J. Biol. Chem. 278 Pages: 51920-51927
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decrease in a specific killer cell immunoglobulin-like receptor on peripheral natural killer cells in women with recurrent miscarriage of unexplained etiology. (2003)
  • Author(s): Yamada, H., Shimada, S., Kato, E., Morikawa, M., Iwabuchi.K., Kishi, R., Onoe, K., Minakami, H.
  • Journal Title: Am. J. Reprod. Immunol. 50 Pages: 149-154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of early and late phase activation of p38 MARK induced by TNF-a or 2,4-dinitrobenzene during maturation of dendritic cells. (2003)
  • Author(s): Iijima, N., Yanagawa.Y., Onoe, K
  • Journal Title: Immunology 110 Pages: 322-328
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Selective regulation of CD40 expression in murine dendritic cells by thiol antioxidants. (2003)
  • Author(s): Iijima, N., Yanagawa.Y., Iwabuchi.K., Onoe, K.
  • Journal Title: Immunology 110 Pages: 197-203
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of histamine on functional maturation of dendritic cells. (2003)
  • Author(s): Pavlinkova, G., Yanagawa, Y., Kikuchi, K., Iwabuchi, K., Ono6, K.
  • Journal Title: Immunobiology 207 Pages: 315-325
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Allograft inflammatory factor-1 (AIF-1) regulates trinitrobenzene sulfonic acid (TNBS)-induced colitis. (2003)
  • Author(s): Morohashi, T., Iwabuchi, K., Watano, K., Nyambayar, D., Mishima, T., Nakai, Y., Shimada, S., Nishida, R., Fujii, S., Onoe, K.
  • Journal Title: Immunology 110 Pages: 112-119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells. (2003)
  • Author(s): Kikuchi, K., Yanagawa, Y., Iwabuchi, K., Onoe, K.
  • Journal Title: Immunol. Lett. 89 Pages: 149-154
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impaired degradation of I K B and β-catenin as a result of targeted disruption of the β TrCP1 gene. (2003)
  • Author(s): Nakayama, K., Hatakeyama, S., Maruyama, S., Kikuchi, A., Onoe, K., Good, R.A., Nakayama, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 100 Pages: 8752-8757
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. (2003)
  • Author(s): Tosa, N., Murakami, M., Jia, W.Y., Yokoyama, M., Masunaga, T, Iwabuchi, C., Inobe, M., Iwabuchi, K., Miyazaki, T., Onoe, K., Uede, T.
  • Journal Title: Int. Immunol. 15 Pages: 741-749
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities. (2003)
  • Author(s): Yanagawa, Y., Onoe, K.
  • Journal Title: Blood 101 Pages: 4923-4929
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] No difference in natural-killer-T cell population, but Th2/Tc2 predominance in peripheral blood of recurrent aborters. (2003)
  • Author(s): Shimada, S., Iwabuchi, K., Kato-Hirayama, E., Morikawa, M., Sakuragi, N., Onoe, K., Minakami, H., Yamada, H.
  • Journal Title: Am. J. Repro. Immunol. 50 Pages: 334-339
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of allograft inflammatory factor-1 in mouse uterus and poly (I : C)-induced fetal resorption. (2003)
  • Author(s): Shimada, S., Iwabuchi, K., Watano, K., Shimizu, H., Yamada, H., Minakami, H., Onoe K.
  • Journal Title: Am. J. Repro. Immunol. 50 Pages: 104-112
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Positive and negative selection of T cell repertoires during differentiation in allogeneic bone marrow chimeras. (2003)
  • Author(s): Onoe, K., Gotohda, T., Nishihori, H., Aranami, T., Iwabuchi, C., Iclozan, C., Morohashi, T., Ogasawara, K., Good, R.A., Iwabuchi.K.
  • Journal Title: Transplant Immunol. 12 Pages: 79-88
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunology and functional genomics of Behcet's disease. (2003)
  • Author(s): Zierhut, M., Mizuki, N., Ohno, S., Inoko, H., Gul, A., Onoe, K, Isogai, E.
  • Journal Title: Cell. Mol. Life Sci. 60 Pages: 1903-1922
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tumor necrosis factor-a but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation. (2003)
  • Author(s): Kikuchi, K., Yanagwa, Y., Aranami, T., Iwabuchi, C., Iwabuchi, K., Onoe, K.
  • Journal Title: Immunology 108 Pages: 42-49
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Larval antigen molecules recognized by adult immune cells of inbred xenopus laevis; Partial characterization and implication in metamorphosis (2002)
  • Author(s): Izutsu, Y.
  • Journal Title: Dev. Growth Differ. 44 Pages: 477-488
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Syngeneic mixed lymphocyte reaction (SMLR) with dendritic cells : Direct visualization of dividing T cell subsets in SMLR (2002)
  • Author(s): Aranami, T.
  • Journal Title: Cell. Immunol. 217 Pages: 67-77
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enhanced complement sensitivity of NK-T cells in murine thymus and spleen associated with presence of serum immunoglobulin (2002)
  • Author(s): Onoe, K.
  • Journal Title: Immunobiology 206 Pages: 377-391
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages (2002)
  • Author(s): Kizaki, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA 99 Pages: 9392-9397
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CCL19 induces rapid dendritic extension of murine dendritic cells (2002)
  • Author(s): Yanagawa, Y.
  • Journal Title: Blood 100 Pages: 1948-1956
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Larval antigen molecules recognized by adult immune cells of inbred xenopus laevis; Partial characterization and implication in metamorphosis. (2002)
  • Author(s): Izutsu, Y., Tochinai, S., Maeno, M., Iwabuchi, K., Onoe, K.
  • Journal Title: Dev. Growth Differ. 44 Pages: 477-488
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Syngeneic mixed lymphocyte reaction (SMLR) with dendritic cells : Direct visualization of dividing T cell subsets in SMLR. (2002)
  • Author(s): Aranami, T., Iwabuchi., K., Onoe, K.
  • Journal Title: Cell. Immunol. 217 Pages: 67-77
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced complement sensitivity of NK-T cells in murine thymus and spleen associated with presence of serum immunoglobulin. (2002)
  • Author(s): Onoe, K., Iwabuchi, K, Iwabuchi, C., Tone, S., Konishi.J., Kawakami, Y., Nishimura, M., Onoe, K.
  • Journal Title: Immunobiology 206 Pages: 377-391
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. (2002)
  • Author(s): Kizaki, T., Suzuki, K., Hitomi, Y., Onoe, K., Day, N.K., Good, R.A., Taniguchi, N., Ohno, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA 99 Pages: 9392-9397
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CCL19 induces rapid dendritic extension of murine dendritic cells. (2002)
  • Author(s): Yanagawa, Y., Onoe, K.
  • Journal Title: Blood 100 Pages: 1948-1956
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced IL-10 production by TLR4 and TLR2 primed dendritic cells upon TLR restimulation.
  • Author(s): Yanagawa, Y., Onoe, K.
  • Journal Title: J. Immunol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Osteopontin aggravates experimental autoimmune uveoretinitis in mice.
  • Author(s): Kitamura, M., Iwabuchi, K., Kitaichi, N., Kon, S., Kitamei, H., Namba, K., Yoshida, K., Denhardt, D.T., Rittling, S., Ohno, S., Uede, T., Onoe, K.
  • Journal Title: J. Immunol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glycogen synthase kinase 3 activity during development of bone marrow-derived dendritic cells (DC) essential for the DC function to induce T helper 2 polarization.
  • Author(s): Ono, T., Yanagawa, Y., Iwabuchi, K., Nonomura, K., Onoe, K.
  • Journal Title: Immunology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] IL-21 enhances dendritic cell ability to induce interferon-y production by natural killer T cells.
  • Author(s): Maeda, M., Yanagawa, Y., Iwabuchi, K., Minami, K., Nakamaru, Y., Takagi, D., Fukuda, S., Onoe, K.
  • Journal Title: Immunobiology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of NK-T-cell hybridomas expressing invariant T-cell antigen receptors.
  • Author(s): Nyambayar, D., Iwabuchi, K., Hedlund, E., Murakawa, S., Shirai, K., Iwabuchi, C., Kon, Y., Miyazaki, Y., Yanagawa, Y., Onoe, K.
  • Journal Title: J. Clin. Exp. Hematopathol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Thl or Th2 balance regulated by interaction between dendritic cells and NK-T cells.
  • Author(s): Onoe, K., Yanagawa.Y., Minami, K., Iijima, N., Iwabuchi, K.
  • Journal Title: Immunol. Res. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice.
  • Author(s): Kitamei, H., Kitaichi, N., Yoshida, K., Nakai, A., Fujimoto, M., Kitamura, M., Iwabuchi, K., Miyazaki, A., Namba, K., Ohno, S., Onoe, K.
  • Journal Title: Immunobiology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] The Immuno-regulatory Role of Natural Killer T Cells in Inflammatory Disease (2005)
  • Author(s): Iwabuchi, K.
  • Total Pages: 19
  • Publisher: Ed. J.L. Croxford, Research Signpost, Kerala, India
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 12^<th> International Congress of Immunology and 4^<th> Annual Conference of FOCIS (2004)
  • Author(s): Iclozan, C.
  • Total Pages: 4
  • Publisher: Medimond S.r.1 Bologna, Italy
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Immunology of Behcet's Disease (2003)
  • Author(s): Onoe, K.
  • Total Pages: 10
  • Publisher: Swets ＆ Zeitlinger, Lisse, The Netherlands
  • Description: 「研究成果報告書概要(和文)」より