2006 Fiscal Year Final Research Report Summary
Molecular mechanism for generating and regenerating neuronal network by CNR family
| Project/Area Number |
14104025
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
YAGI Takeshi Osaka Univ., Graduate School Frontier Biosci., Prof., 大学院生命機能研究科, 教授 (10241241)
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| Co-Investigator(Kenkyū-buntansha) |
HIRABAYASHI Takahiro Osaka Univ., Graduate School Frontier Biosci., Assistant Prof., 大学院生命機能研究科, 助手 (40297015)
HAMADA Shun Fukuoka Women's Univ., Department of Nutrition and Health Science, Faculty of Human Environmental Science, Associate Prof., 人間環境学部・栄養健康科学科, 助教授 (60282349)
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| Project Period (FY) |
2002 – 2006
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| Keywords | cadherin / neuron / neural network / divesity / genome / gene cluster / gene regulation / mouse |
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| Research Abstract |
Brain is a complex system which is composed of enormous number of diverse neurons. CNR/Protocadherin (Pcdh) family is constituted with gene cluster like immunoglobulin and T cell receptor genes. The CNR/Pcdh proteins are localized in synapses and developmental axons. They are differentially expressed in individual neurons. In this project, to examine molecular mechanism for neural network formation and rearrangement, we focus to the CNR/Pcdh family in the brain. This project demonstrated that 1) mouse CNR1 (Pcdha4) protein gains cell adhesion activity via active integrin proteins, 2) we firstly revealed protein structure of protocadherin family by NMR spectroscopy, 3) CNR/Pcdha proteins highly express in the developmental axons and decline from initial formation of myelin, and their down regulation is regulated by myelination, 4) producing gene converted mice of the CNR/Pcdha family reveals their essential roles for precise neural network formation, and 5) we discover novel gene regulation of the CNR/Pcdh gene clusters in individual Purkinje cells. Thus this project successfully reveals that the diverse CNR/Pcdh family molecules play roles for cell adhesion activity, establishment for neuronal diversity and neural network formation in the brain.
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Research Products
(124 results)
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[Journal Article] Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers.2007
Author(s)
Suto F, Tsuboi M, Kamiya H, Mizuno H, Kiyama Y, Komai S, Shimizu M, Sanbo M, Yagi T, Hiromi Y, Chedotal A, Mitchell KJ, Manabe T, Fujisawa H.
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Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.2007
Author(s)
Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, Sakai R, Ishige A, Watanabe K, Akita M, Yagi T, Tanaka K, Asou H.
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Journal Title
J Neurosci Res 85
Pages: 954-66
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.2006
Author(s)
Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M.
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Journal Title
J Neurochem 98
Pages: 45-56
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.2006
Author(s)
Morita A, Yamashita N, Sasaki Y, Uchida Y, Nakajima 0, Nakamura F, Yagi T, Taniguchi M, Usui H, Katoh-Semba R, Takei K, Goshima Y.
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Journal Title
J Neurosci 26
Pages: 2971-2980
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis.2006
Author(s)
Kai N, Iwase K, Imai K, Nakahira E, Soma M, Ohtsuka S, Yagi T, Kobayashi K, Koga H, Takiguchi M, Yuasa S.
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Journal Title
Brain Res 1073-1074
Pages: 60-70
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice.2005
Author(s)
Osada T, Tamamaki N, Song S-Y, Kakazu N, Yamazaki Y, Makino H, Sasaki A, Hirayama T, Hamada S, Nave K-A, Yanagimachi R, Yagi T.
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Journal Title
J Neurosci 25
Pages: 8368-8374
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.2005
Author(s)
Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Li Xu, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S.
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Journal Title
Eur J Neurosci 22
Pages: 1445-1454
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Fc{varepsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.2005
Author(s)
Nishida K, Yamasaki S, Ito Y, Kabu K, Hattori K, Tezuka T, Nishizumi H, Kitamura D, Goitsuka R, Geha RS, Yamamoto T, Yagi T, Hirano T.
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Journal Title
J Cell Biol 170
Pages: 115-126
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Plexin-A4 Mediates Axon-Repulsive Activities of Both Secreted and Transmembrane Semphorins and Play Roles in Nerve Fiber Guidance.2005
Author(s)
Sudo F, Ito K, Uemura M, Shimizu M, Shinkawa Y, Sanbo M, Shinoda T, Tsuboi M, Takashima S, Yagi T, Fujisawa H.
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Journal Title
J Neurosci 25
Pages: 3628-3637
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Coordination of trigeminal axon navigation and patterning with tooth organ formation : epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbetal regulate semaphorin 3a expression in the dental mesenchyme.2005
Author(s)
Kettunen P, Loes, S, Furmanek T, Field K, Kvinnsland IH, Behar O, Yagi T, Fujisawa H, Vainio S, Taguchi M, Luukko K.
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Journal Title
Development 132
Pages: 323-334
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genomic organization and transcripts of the zebrafish Protocadherin genes.2004
Author(s)
Tada T, Senzaki K, Tai Y, Morishita H, Tanaka Y, Murata Y, Ishii Y, Asakawa S, Shimizu N, Sugino H, Yagi T.
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[Journal Article] Signaling via Immunoglobulin Fc Receptors Induces Oligodendrocyte Precursor Cell Differentiation.2003
Author(s)
Nakahara J, Tan-Takeuchi K, Seiwa C, Gotoh M, Kaifu T, Ujike A, Inui M, Yagi T, Ogawa M, Aiso S, Takai T, Asou H.
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Journal Title
Dev Cell 4
Pages: 841-852
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cutting edge : Fyn is essential for tyrosinase phosphorylation of Csk-binding protein /phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.2002
Author(s)
Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, Minami Y, Kato A, Tani-Ichi S, Hamaoka T, Kosugi A.
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Journal Title
J Immunol 169
Pages: 2813-2817
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Fyn and Cdk5 Mediate Semaphorin-3A Signaling, Which is Involved in Regulation of Dendrite Orientation in Cerebral Cortex.2002
Author(s)
Sasaki Y, Cheng C, Uchida Y, Nakajima 0, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y.
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