2005 Fiscal Year Final Research Report Summary
A comprehensive study on risk factors of mild cognitive impairment (MCI)-aiming for a new strategy of dementia prevention
| Project/Area Number |
14207021
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | National Institute for Longevity Sciences / National Center for Geriatrics and Gerontology |
|---|
Principal Investigator |
SHIMOKATA Hiroshi National Institute for Longevity Sciences, Department of Epideniology, Head, (研究所)・疫学研究部, 部長 (10226269)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ANDO Fujiko National Institute for Longevity Sciences, Department of Epideniology, Head, (研究所)・疫学研究部, 室長 (90333393)
NIINO Naoakira Obirin University, Graduate School of International Studies, 大学院・国際学研究科, 教授 (40201686)
|
|---|
| Project Period (FY) |
2002 – 2005
|
| Keywords | Cognitive impairment / Intelligence test / Short-term memory / Aging / Verbal intelligence / Active intelligence / Longitudinal study / Genotype |
|---|
| Research Abstract |
The purpose of this study is to clarify the actual condition of age-related cognitive impairment and its risk factors. The subjects were 2300 randomly selected community-living population. They were followed up every tow years from 1997. The fourth examination was finished in July 2006. The data of adult intelligence test (WAIS-R), cognitive function test (MMSE), memory test, and various indices of psychology were collected and released on the Internet as monograph. Incidence of mild cognitive impairment (MCI) and associations of cognitive function with genotype, clinical findings including of head MRI, life-style, and effect of aging were examined cross-sectionally and longitudinally. Incidence of MCI was 4.2 percent in the subjects aged 60 years and over. The incidence increased with age, and no gender difference was found. The genotypes of Klotho gene and Cholecystokinin A receptor gene influenced cognitive function of middle-aged and elderly individuals. The best combination of genotype to estimate of cognitive impairment was found by exhaustive analysis of genotypes. The effects of aging on verbal and active intelligence, and gender and aging differences in delayed episode memory were clarified. Intellectual activities such as reading books significantly prevent both verbal and active intelligence impairment, while sporting activity and domestic labor prevented only active intelligence impairment. Antioxidant vitamins had preventive effects for cognitive impairment. Smoking accelerated cognitive impairment. Cognitive function showed positive correlations with serum indices of health such as albumin, HDL-cholesterol and calcium levels, and negative correlations with serum indices of inflammation and disease markers. As for the head MRI findings, white matter lesions and lacuna infarction of cerebrum were associated with cognitive impairment.
|
