2005 Fiscal Year Final Research Report Summary
Development of Molecular Diagnostic System of Urological Tumors Using a Novel Program for Genetic Analysis
| Project/Area Number |
14207062
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Department of Urology, Kyoto University Graduate School of Medicine |
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Principal Investigator |
OGAWA Osamu Kyoto University, Graduate School of Medicine, Department of Urology, Professor, 医学研究科, 教授 (90260611)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Hiroyuki Kyoto University, Graduate School of Medicine, Department of Urology, Assistant Professor, 医学研究科, 講師 (20324642)
ITO Noriyuki Kyoto University, Graduate School of Medicine, Department of Urology, Assistant Professor, 医学研究科, 講師 (70343225)
FUKUSHIMA Masanori Kyoto University, Graduate School of Medicine, Translational Research Center, Professor, 医学研究科, 教授 (80107820)
NAITO Saiji Kyoto University, Graduate School of Medicine, Department of Urology, Professor, 医学研究院, 教授 (40164107)
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| Project Period (FY) |
2002 – 2005
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| Keywords | Bladder cancer / Prostate cancer / Renal cancer / Molecular diagnosis / Expression profile / DNA array / Polymorphic analysis / Treatment response |
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| Research Abstract |
1) We conducted a multi-institutional retrospective outcome-study on the patients with invasive bladder cancer who underwent radical cystectomy. This outcome study enrolling more than 1000 patients showed the clinical significance of the patient's selection in terms of chemo-sensitivity, and also indicated that the response of primary tumor to the chemotherapy might be a useful surrogate endpoint for the prediction of the survival benefit of the patients. In order to overcome drug-resistance of cancer cells, we focused attention on NQO1, an enzyme with ROS activity and specifically over-expressed in bladder cancer cells. In this analysis suggested that dicoumarol, an inhibitor against NQO1, could enhance cytotoxicity of CDDP in urogenital cancer cells with wild-type p53 through the p53/p21/JNK pathway.
2) By using cDNA microarray analysis on RCC specimens, we revealed more than 10 genes associated with clinical outcome of RCC, and the functional analysis on these genes are now ongoing. In addition, we have just started a multi-institutional outcome study enrolling more than 1000 RCC patients.
3) By using tissue-microarray analysis, we investigated the association between the expression pattern of prostate cancer related proteins and the clinical outcome. In addition, we established a novel androgen-dependent prostate cancer xenograft, and showed the molecular mechanism of hormone-independency associated with AR mutations.
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[Journal Article] Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population.2005
Author(s)
Kamoto T, Isogawa Y, Shimizu Y, Minamiguchi S, Kinoshita H, Kakehi Y, Mistumori K, Yamamoto S, Habuchi T, Kato T, Ogawa O.
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Journal Title
Jpn.J.Clin.Oncol. 35
Pages: 158-161
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Int. J. Clin. Oncol., 10:133-138, 2005 T. CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.2005
Author(s)
Zhenhua L, Tsuchiya N, Narita S, Inoue T, Horikawa Y, Kakinuma H, Kato T, Ogawa O, Habuchi.
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Journal Title
Cancer Lett. 225
Pages: 237-243
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population.2005
Author(s)
lnoue T, Segawa T, Shiraishi T, Yoshida T, Toda Y, Yamada T, Kinukawa N, Kinoshita H, Kamoto T, Ogawa O.
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Journal Title
Urology 66
Pages: 332-337
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Clinical Outcome of a Large-Scale Multi-Institutional Retrospective Study for Locally Advanced Bladder Cancer : A Survey Including 1131 Patients Treated during 1990-2000 in Japan.2004
Author(s)
Nishiyama H, Habuchi T, Watanabe J, Teramukai S, Tada H, Ono Y, Ohshima S, Fujimoto K, Hirao Y, Fukushima M, Ogawa O.
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Journal Title
Eur Urol. 45
Pages: 176-181
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism.2003
Author(s)
Wang L, Habuchi T, Mitsumori K, Li Z, Kamoto T, Kinoshita H, Tsuchiya N, Sato K, Ohyamam C, Nakamura A, Ogawa O, Kato T
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Journal Title
Int.J.Cancer 103
Pages: 116-120
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer.2003
Author(s)
Wang L, Habuchi T, Tsuchiya N, Mitsumori K, Ohyama C, Sato K, Kinoshita H, Kamoto T, Nakamura A, Ogawa O, Kato T.
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Journal Title
Cancer Res. 63
Pages: 4407-4411
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Factors that influence the results of salvage surgery in patients with chemorefractory germ cell carcinomas with elevated tumor markers.2003
Author(s)
Habuchi T, Kamoto T, Hara I, Kawai K, Nakao M, Nonomura N, Kobayashi T, Ogawa O, Kamidono S, Akaza H, Okuyama A, Kato T, Miki T.
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Journal Title
Cancer 98
Pages: 1635-1642
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese population.2003
Author(s)
Wang LZ, Sato K, Tsuchiya N, Yu JG, Ohyama C, Satoh S, Habuchi T, Ogawa O, Kato T.
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Journal Title
Cancer Lett. 202
Pages: 53-59
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genetic polymorphisms of the lnterleukin-4 receptor a gene are associated with an increasing risk and poor prognosis of sporadic renal cell carcinoma in a Japanese Population.2002
Author(s)
Nakamura E, Megumi Y, Kobayashi T, Kamoto T, Ishitoya S, Terachi T, Tachibana M, Matsushiro H, Habuchi T, Kakehi Y, Ogawa O.
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Journal Title
Clin.Cancer Res. 8
Pages: 2620-2625
Description
「研究成果報告書概要(欧文)」より
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