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2005 Fiscal Year Final Research Report Summary

Development of Molecular Diagnostic System of Urological Tumors Using a Novel Program for Genetic Analysis

Research Project

Project/Area Number 14207062
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionDepartment of Urology, Kyoto University Graduate School of Medicine

Principal Investigator

OGAWA Osamu  Kyoto University, Graduate School of Medicine, Department of Urology, Professor, 医学研究科, 教授 (90260611)

Co-Investigator(Kenkyū-buntansha) NISHIYAMA Hiroyuki  Kyoto University, Graduate School of Medicine, Department of Urology, Assistant Professor, 医学研究科, 講師 (20324642)
ITO Noriyuki  Kyoto University, Graduate School of Medicine, Department of Urology, Assistant Professor, 医学研究科, 講師 (70343225)
FUKUSHIMA Masanori  Kyoto University, Graduate School of Medicine, Translational Research Center, Professor, 医学研究科, 教授 (80107820)
NAITO Saiji  Kyoto University, Graduate School of Medicine, Department of Urology, Professor, 医学研究院, 教授 (40164107)
Project Period (FY) 2002 – 2005
KeywordsBladder cancer / Prostate cancer / Renal cancer / Molecular diagnosis / Expression profile / DNA array / Polymorphic analysis / Treatment response
Research Abstract

1) We conducted a multi-institutional retrospective outcome-study on the patients with invasive bladder cancer who underwent radical cystectomy. This outcome study enrolling more than 1000 patients showed the clinical significance of the patient's selection in terms of chemo-sensitivity, and also indicated that the response of primary tumor to the chemotherapy might be a useful surrogate endpoint for the prediction of the survival benefit of the patients. In order to overcome drug-resistance of cancer cells, we focused attention on NQO1, an enzyme with ROS activity and specifically over-expressed in bladder cancer cells. In this analysis suggested that dicoumarol, an inhibitor against NQO1, could enhance cytotoxicity of CDDP in urogenital cancer cells with wild-type p53 through the p53/p21/JNK pathway.
2) By using cDNA microarray analysis on RCC specimens, we revealed more than 10 genes associated with clinical outcome of RCC, and the functional analysis on these genes are now ongoing. In addition, we have just started a multi-institutional outcome study enrolling more than 1000 RCC patients.
3) By using tissue-microarray analysis, we investigated the association between the expression pattern of prostate cancer related proteins and the clinical outcome. In addition, we established a novel androgen-dependent prostate cancer xenograft, and showed the molecular mechanism of hormone-independency associated with AR mutations.

  • Research Products

    (48 results)

All 2006 2005 2004 2003 2002

All Journal Article (48 results)

  • [Journal Article] Evaluation for surrogacy of end points by using data from observational studies : tumor downstaging for evaluating neoadjuvant chemotherapy in invasive bladder cancer.2006

    • Author(s)
      Teramukai S, Ogawa O
    • Journal Title

      Clin Cancer Res. 12

      Pages: 139

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population.2006

    • Author(s)
      Awakura Y, Ogawa O
    • Journal Title

      Cancer Lett. (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of the PIG3 Promoter Polymorphism with Invasive Bladder Cancer in a Japanese Population.2006

    • Author(s)
      Ito M, Ogawa O
    • Journal Title

      Jpn J Clin Oncol. 36

      Pages: 116

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenitial cancer cell lines.2006

    • Author(s)
      Watanabe J, Ogawa O
    • Journal Title

      Oncogene (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation for surrogacy of endpoints by using data from observational studies : tumor downstaging for evaluating neoadjuvant chemotherapy in invasive bladder cancer.2006

    • Author(s)
      Teramukai S, Nishiyama H, Matsui Y, Ogawa O, Fukushima M.
    • Journal Title

      Clin.Cancer Res. 12

      Pages: 139-143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population.2006

    • Author(s)
      Awakura Y, Ito N, Nakamura E, Takahashi T, Kotani H, Mikami Y, Manabe T, Kamoto T, Habuchi T, Ogawa O.
    • Journal Title

      Cancer Lett. in press

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of the PIG3 Promoter Polymorphism with Invasive Bladder Cancer in a Japanese Population.2006

    • Author(s)
      Ito M, Nishiyama H, Watanabe J, Kawanishi H, Takahashi T, Kamoto T, Habuchi T, Ogawa O.
    • Journal Title

      Jpn J Clin Oncol. 36

      Pages: 116-120

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines.2006

    • Author(s)
      Watanabe J, Nishiyama H, Matsui Y, Ito M, Kawanishi H, Kamoto T, Ogawa O.
    • Journal Title

      Oncogene (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia.2005

    • Author(s)
      Tsuchiya N, Ogawa 0
    • Journal Title

      Int.J.Oncol. 26

      Pages: 225

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population.2005

    • Author(s)
      Kamoto T, Ogawa 0
    • Journal Title

      Jpn.J.Clin.Oncol. 35

      Pages: 158

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The current status of perioperative chemotherapy for invasive bladder cancer : a multiinstitutional retrospective study in Japan.2005

    • Author(s)
      Matsui Y, Ogawa 0
    • Journal Title

      Int.J.Clin.Oncol. 10

      Pages: 133

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.2005

    • Author(s)
      Zhenhua L, Ogawa 0
    • Journal Title

      Cancer Lett. 225

      Pages: 237

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population.2005

    • Author(s)
      Inoue T, Ogawa 0
    • Journal Title

      Urology. 66

      Pages: 332

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient.2005

    • Author(s)
      Yoshida T, Ogawa 0
    • Journal Title

      Cancer Res. 65

      Pages: 9611

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia.2005

    • Author(s)
      Tsuchiya N, Wang L, Horikawa Y, lnoue T, Kakinuma H, Matsuura S, Sato K, Ogawa O, Kato T, Habuchi T.
    • Journal Title

      Int.J.Oncol. 26

      Pages: 225-231

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population.2005

    • Author(s)
      Kamoto T, Isogawa Y, Shimizu Y, Minamiguchi S, Kinoshita H, Kakehi Y, Mistumori K, Yamamoto S, Habuchi T, Kato T, Ogawa O.
    • Journal Title

      Jpn.J.Clin.Oncol. 35

      Pages: 158-161

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The current status of perioperative chemotherapy for invasive bladder cancer : a multiinstitutional retrospective study in Japan.2005

    • Author(s)
      Matsui Y, Nishiyama H, Watanabe J, Teramukai S, Ono Y, Ohshima S, Fujimoto K, Hirao Y, Fukushima M, Ogawa O.
    • Journal Title

      Int.J.Clin.Oncol. 10

      Pages: 133-138

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Int. J. Clin. Oncol., 10:133-138, 2005 T. CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.2005

    • Author(s)
      Zhenhua L, Tsuchiya N, Narita S, Inoue T, Horikawa Y, Kakinuma H, Kato T, Ogawa O, Habuchi.
    • Journal Title

      Cancer Lett. 225

      Pages: 237-243

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population.2005

    • Author(s)
      lnoue T, Segawa T, Shiraishi T, Yoshida T, Toda Y, Yamada T, Kinukawa N, Kinoshita H, Kamoto T, Ogawa O.
    • Journal Title

      Urology 66

      Pages: 332-337

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient.2005

    • Author(s)
      Yoshida T, Kinoshita H, Segawa T, Nakamura E, Inoue T, Shimizu Y, Kamoto T, Ogawa O.
    • Journal Title

      Cancer Res. 65

      Pages: 9611-9616

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical Outcome of a Large-Scale Multi-Institutional Retrospective Study for Locally Advanced Bladder Cancer. A Survey Including 1131 Patients Treated during 1990-2000 in Japan.2004

    • Author(s)
      Nishiyama H, Ogawa O
    • Journal Title

      Eur Urol. 45

      Pages: 176

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Radical cystectomy for invasive bladder cancer. results of multi-institutional pooled analysis.2004

    • Author(s)
      Takahashi A, Ogawa O
    • Journal Title

      Jpn.J.Clin.Oncol. 34

      Pages: 14

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Microsatellite polymorphism of steroid hormone synthesis gene CYP1L1 is associated with advanced prostate cancer.2004

    • Author(s)
      Kumazawa T, Ogawa O
    • Journal Title

      Int.J.Cancer 110

      Pages: 140

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.2004

    • Author(s)
      Ichimura Y, Ogawa O
    • Journal Title

      J.Urol. 172

      Pages: 728

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer.2004

    • Author(s)
      Ito M, Ogawa O
    • Journal Title

      Urology 64

      Pages: 74

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of lipoprotein lipase gene polymorphism with risk of prostate cancer in a Japanese population.2004

    • Author(s)
      Narita S, Ogawa O
    • Journal Title

      Int.J.Cancer 112

      Pages: 872

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of the cyclin D1 G870A polymorphism with susceptibility to sporadic renal cell carcinoma.2004

    • Author(s)
      Yu J, Ogawa 0
    • Journal Title

      J.Urol. 172

      Pages: 2410

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Clinical Outcome of a Large-Scale Multi-Institutional Retrospective Study for Locally Advanced Bladder Cancer : A Survey Including 1131 Patients Treated during 1990-2000 in Japan.2004

    • Author(s)
      Nishiyama H, Habuchi T, Watanabe J, Teramukai S, Tada H, Ono Y, Ohshima S, Fujimoto K, Hirao Y, Fukushima M, Ogawa O.
    • Journal Title

      Eur Urol. 45

      Pages: 176-181

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Radical cystectomy for invasive bladder cancer : results of multi-institutional pooled analysis.2004

    • Author(s)
      Takahashi A, Ogawa O et al.
    • Journal Title

      Jpn.J.Clin.Oncol. 34

      Pages: 14-19

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Microsatellite polymorphism of steroid hormone synthesis gene CYP11A1 is associated with advanced prostate cancer.2004

    • Author(s)
      Kumazawa T, Tsuchiya N, Wang L, Sato K, Kamoto T, Ogawa O, Nakamura A, Kato T, Habuchi T.
    • Journal Title

      Int.J.Cancer 110

      Pages: 140-144

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.2004

    • Author(s)
      Ichimura Y, Habuchi T, Tsuchiya N, Wang L, Oyama C, Sato K, Nishiyama H, Ogawa O, Kato T.
    • Journal Title

      J.Urol. 172

      Pages: 728-732

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer.2004

    • Author(s)
      Ito M, Habuchi T, Watanabe J, Higashi S, Nishiyama H, Wang L, Tsuchiya N, Kamoto T, Ogawa O.
    • Journal Title

      Urology 64

      Pages: 74-78

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of lipoprotein lipase gene polymorphism with risk of prostate cancer in a Japanese population2004

    • Author(s)
      Narita S, Tsuchiya N, Wang L, Matsuura S, Ohyama C, Satoh S, Sato K, Ogawa O, Habuchi T, Kato T.
    • Journal Title

      Int.J.Cancer 112

      Pages: 872-876

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of the cyclin D1 gene G870A polymorphism with susceptibility to sporadic renal cell carcinoma.2004

    • Author(s)
      Yu J, Habuchi T, Tsuchiya N, Nakamura E, Kakinuma H, Horikawa Y, Inoue T, Ogawa O, Kato T.
    • Journal Title

      J.Urol. 172

      Pages: 2410-2413

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genetic polymorphisms of the Interleukin-4 receptor a gene are associated with an increasing risk and poor prognosis of sporadic renal cell carcinoma in a Japanese Population.2003

    • Author(s)
      Nakamura E, Ogawa 0
    • Journal Title

      Clin.Cancer Res 8

      Pages: 2620

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism.2003

    • Author(s)
      Wang L, Ogawa O
    • Journal Title

      Int.J.Cancer 103

      Pages: 116

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population.2003

    • Author(s)
      Li A, Ogawa O
    • Journal Title

      J.Urol. 169

      Pages: 2378

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Insulin-like growth factor-binding protein-3 gene-202A/C polymorphism is correlated with advanced disease status in prostate cancer.2003

    • Author(s)
      Wang L, Ogawa O
    • Journal Title

      Cancer Res. 63

      Pages: 4407

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Factors that influence the results of salvage surgery in patients with chemorefractory germ cell carcinomas with elevated tumor markers.2003

    • Author(s)
      Habuchi T, Ogawa O
    • Journal Title

      Cancer 98

      Pages: 1635

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Polymorphisms in prostate-specific antigen (PSA) gene,risk of prostate cancer, and serum SPA levels in Japanese population.2003

    • Author(s)
      Wang L, Ogawa O
    • Journal Title

      Cancer Lett. 202

      Pages: 53

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism.2003

    • Author(s)
      Wang L, Habuchi T, Mitsumori K, Li Z, Kamoto T, Kinoshita H, Tsuchiya N, Sato K, Ohyamam C, Nakamura A, Ogawa O, Kato T
    • Journal Title

      Int.J.Cancer 103

      Pages: 116-120

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population.2003

    • Author(s)
      Li Z, Habuchi T, Mitsumori K, Kamoto T, Kinoshita H, Segawa T, Ogawa, O Kato T.
    • Journal Title

      J.Urol. 169

      Pages: 2378-2381

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer.2003

    • Author(s)
      Wang L, Habuchi T, Tsuchiya N, Mitsumori K, Ohyama C, Sato K, Kinoshita H, Kamoto T, Nakamura A, Ogawa O, Kato T.
    • Journal Title

      Cancer Res. 63

      Pages: 4407-4411

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Factors that influence the results of salvage surgery in patients with chemorefractory germ cell carcinomas with elevated tumor markers.2003

    • Author(s)
      Habuchi T, Kamoto T, Hara I, Kawai K, Nakao M, Nonomura N, Kobayashi T, Ogawa O, Kamidono S, Akaza H, Okuyama A, Kato T, Miki T.
    • Journal Title

      Cancer 98

      Pages: 1635-1642

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese population.2003

    • Author(s)
      Wang LZ, Sato K, Tsuchiya N, Yu JG, Ohyama C, Satoh S, Habuchi T, Ogawa O, Kato T.
    • Journal Title

      Cancer Lett. 202

      Pages: 53-59

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Single nucleotide polymorphisms in the 3' untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinoma.2002

    • Author(s)
      Abe A, Ogawa O
    • Journal Title

      Tohoku J.Exp.Med. 198

      Pages: 181

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Genetic polymorphisms of the lnterleukin-4 receptor a gene are associated with an increasing risk and poor prognosis of sporadic renal cell carcinoma in a Japanese Population.2002

    • Author(s)
      Nakamura E, Megumi Y, Kobayashi T, Kamoto T, Ishitoya S, Terachi T, Tachibana M, Matsushiro H, Habuchi T, Kakehi Y, Ogawa O.
    • Journal Title

      Clin.Cancer Res. 8

      Pages: 2620-2625

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Single nucleotide polymorphisms in the 3' untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinoma.2002

    • Author(s)
      Abe A, Sato K, Habuchi T, Wang L, Li Z, Tsuchiya N, Ohyama C, Satoh S, Ogawa O, Kato T.
    • Journal Title

      Tohoku J.Exp.Med. 198

      Pages: 181-190

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

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